Báo cáo y học: "Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesi" pps

... methods). Mahony et al. Genome Biology 2011, 12:R2 http://genomebiology.com/2011/12/1/R2 Page 7 of 15 RESEARCH Open Access Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesis Shaun ... [http://www.csie.ntu.edu. tw/~cjlin/libsvm/]. doi:10.1186/gb-2011-12-1-r2 Cite this article as: Mahony et al.: Ligand-dependent dynamics of retinoic ac...

Ngày tải lên: 09/08/2014, 22:23

... amidolytic activity was obtained by showing that commercial PAP hydrolysed the Abz-ISYQSSSTEEQ- EDDnp substrate at neutral pH, as does the puri®ed enzyme. The ratio of the amidolytic activity of ... ommercially. Some of them were cleaved by at least two other proteases obtained by ion exchange chro- matography from crude seminal plasma. This study shows that one of these enzymes is pr...

Ngày tải lên: 24/03/2014, 00:21

... mpor- tance of Arg97 and Arg108 in the activity of CYP2C9, especially for substrate binding, by site-directed mutagenesis and homology modelling. The phenotypical abnormality of hypertension ... specificity of other cytochromes P450 [47]. Our finding of an exclusive increase in the 1 1b-hydroxy- lation capacity of CYP11B2 by the replacement D147E indicates that residue 147 in the C...

Ngày tải lên: 24/03/2014, 03:21

... Ets-1/Smad3 synergy. Addition of the general PKC inhibitor bisindolylmaleimide I (bis; 10 µM) blocks the ability of Ets-1 to activate the CCN2 promoter. Conversely, addition of bisindolylmaleimide ... induction of tenascin-C is potentiated by Ets- 1; however, the TGFβ-induction of type I collagen is impaired by Ets-1 [30,34,42]. Given that Ets-1 is induced during the early phas...

Ngày tải lên: 09/08/2014, 07:20

... purposes) chemical and radioimmunoassay analysis. Arthritis Rheum 1995, 38:699-709. 21. Palmblad K, Harris-Erlandsson H, Tracey KJ, Andersson U: Dynamics of early synovial cytokine expression in rodent ... similar to those of IL-1β, in which most of the expression was evident Figure 1 Synovial cytokine expression at an early disease-preceding time pointSynovial cytokine expression...

Ngày tải lên: 09/08/2014, 10:20

... dis- order of unknown etiology. Lymphocytic infiltration of the lach- rymal and salivary glands leads to dry mouth (xerostomia) and dry eyes (xerophthalmia). It has been assumed that a combina- tion of ... instructions (Euroimmun). Preparation of lymphocytes and flow cytometry Lymphocyte suspensions were prepared from spleens and lymph nodes. For flow cytometric analysis, 1 × 10 6 ce...

Ngày tải lên: 09/08/2014, 10:23

... Dixey J, Solymossy C, Young A, Early RA study: Is it possible to predict radiological damage in early rheumatoid arthritis? A report on the occurrence, progression and prognostic factors of radiological ... 2000, 27:571-574. 29. Garnero P, Gineyts E, Finck B, Delmas PD: Association of base- line levels of urinary glucosyl-galactosyl-pyridinoline and type II collagen C-telopeptide wi...

Ngày tải lên: 09/08/2014, 13:21

... techniques such as delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and T1-rho and T2-mapping have promise to assess tissue quality by indirectly measuring glycosaminoglycan content [3,4]. ... colleagues investigated the use of monoclonal antibodies and enzyme-linked immuno- sorbent assay to quantify serum levels of CS and HA, respectively, in a dog model. They followed two groups...

Ngày tải lên: 09/08/2014, 14:21

... in the early RA cohort were taken at study entry and subsequently after two years of observation. In the retrospective study, the last available radiograph taken during the first 10 years of disease duration ... according to the 1987 revised criteria of the American College of Rheumatol- ogy were included in the study. The study design was approved by the University of Leipzig&a...

Ngày tải lên: 09/08/2014, 14:21

... terms of the amount of evolutionary history that is unique to either of the two: for a pair of communities, the sum of the lengths of the branches on a phylogenetic tree that leads only to ... 5 Department of Computer Science, 9 Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA. 2 Department of Microbiology and Immunology, Stanf...

Ngày tải lên: 09/08/2014, 20:21