Báo cáo y học: " Detecting sequence polymorphisms associated with meiotic recombination hotspots in the human genome" pptx

... since the 13-mer motif occurs in only about 40% of human hotspots [32] and the variation in the zinc finger array of the Prdm9 gene can expl ain only about 18% of varia- tion in human recombination ... analysis could not find any local polymorphisms associated with the variation i n crossover rate in hotspots MSTM1a and MSTM1b on human chromosome 1 [45]. Si...

Ngày tải lên: 09/08/2014, 22:23

... CpG density) may prevent nucleosome assembly, considering the active chromatin structure of CGIs in vivo [17]. Expectedly, the in vivo nucleosome occupancy within the CGI is remarkably low compared ... website [30]. DNA methylation in human T cells was mapped to the human genome by using methyl- CpG-binding domain (MBD) proteins and Solexa sequencing technology [31]. These d...

Ngày tải lên: 09/08/2014, 20:22

... two distinct aspirin hydrolysis pathways act: a spontaneous pH-dependent hydrolysis and an en- zymatic hydrolysis by plasma/serum and erythrocyte esterases (6). The circulating aspirin esterase ... are mainly due to butyrylcholinesterase (BChE, pseudocholinesterase) and, in part, to albumin (6). Because of higher aspirin esterase activity lead- ing to faster aspirin hydrolysis, the...

Ngày tải lên: 26/10/2012, 09:39

... assessment. Discussion Statins are one of the most effective medicines intro- duced in the past 25 years. Nonetheless they are still relatively under prescribed, especially in patients without symptomatic or obvious ather ... f patients in both the statin and non-statin treated groups. Patients were considered t o be in the “ statin” group if they were taking statins at the...

Ngày tải lên: 10/08/2014, 10:20

... with thickening of the lining layer (or intima) and infiltration of the sublining layer, mainly by macrophages and lymphocytes [1]. In addition, the fluid- filled joint cavity contains numerous ... CXCL8 binding. The chemokine binding sites described on phagocytes may be involved in the migration of these cells into the inflamed joint. Keywords: chemokines, inflamed, recepto...

Ngày tải lên: 09/08/2014, 03:24

... multiple c raniosynostectomies but she did well at the University and was also able to play the piano. Our patient had many of the clinical and anatomic findings typical of OTCS: the dysmorphic face, ... described by Lalatta [4] and by Azimi [5], cerebral hemorrhage [3] and hearing loss as reportedbyNacarkucuketal.[6]andZampinoetal. [7]. We did not find any genetic abnormality either...

Ngày tải lên: 10/08/2014, 23:21

... points to inflammation in RA being associ- ated with a worsening of the lipid profile [4,5], a factor already present early in the disease [6]. Dyslipidemia in RA is mainly presented by low concentrations ... [24-27]. The purpose of this study was to analyze if the type of diet over the previous year, determined by FFQ, was associated with body composition derangement an...

Ngày tải lên: 09/08/2014, 13:22

... that by increasing the number of starting points, the performance of the method improves. In the light of these results, the number of starting points is selected to be very large. We then explore ... listed in Table 1. The number of starting points in the algorithm was set at 1 or 100. Starting points were selected according to the MEME procedure as described in th...

Ngày tải lên: 09/08/2014, 20:20

... food insecurity. Clin Infect Dis 2009, 49(7):1096-102. 3. Campa A, Yang Z, Lai S, et al: HIV-related wasting in HIV-infected drug users in the era of highly active antiretroviral therapy. Clin Infect ... the original work is properly cited. the final analy sis. Subjects t hat were e ither enrolled in or discontinued from food rations by the clinical team during the period of...

Ngày tải lên: 10/08/2014, 05:21

... plan. Introduction Dentigerous cysts are the most common developmental odontogenic cysts, accounting for approximately 25% of all odontogenic cysts of the jaws. They are frequently noted as an incidental finding on radiographs ... eosin-stained sections of the specimen were prepared. The histopatholo- gic sections showed a cyst lined by thin, non-keratinized, stratified squamous epith...

Ngày tải lên: 10/08/2014, 23:21