Báo cáo y học: "A statistical approach for detecting genomic aberrations in heterogeneous tumor samples from single nucleotide polymorphism genotyping data" pot

... as: Yau et al.: A statistical approach for detecting genomic aberrations in heterogeneous tumor samples from single nucleotide polymorphism genotyping data. Genome Biology 2010 11:R92. Submit your ... allelic composition in nonpaired, primary tumor specimens by use of affymetrix single- nucleotide- polymorphism genotyping microarrays. Am J Hum Genet 200...

Ngày tải lên: 09/08/2014, 22:23

... histone modification may influence another by recruiting or activating chromatin-modifying complexes [27]. How- ever, a study in yeast revealed only simple and cumula- tive functional consequences for combinations ... the chromatin features are redundant, and to what extent they are interac ting in a combinatorial fashion. Specifically, for each bin, we modeled the expression level y...

Ngày tải lên: 09/08/2014, 22:23

... set up for each experiment. The floating cells were harvested one day later and viable cellrecovery was determined by Trypan Blue staining with a hemocytometer followed by FACS staining for CD83 ... unstained and stained populations in the histograms are shown in grey and red, respectively. In the case of CD86 and CD83 staining, the surface expression on cells from non-matured c...

Ngày tải lên: 11/08/2014, 10:23

... accuracy. Current standard therapy includes a combination of pegylated interferon and ribavirin. Response rate is approximately 40% for genotype 1 and 80% for genotypes 2 and 3, respectively. Successful ... A phase II study indicated a lower rate of anemia induced by viramidine than ribavirin. However, its efficacy remains to be determined by ongoing clinical trials. Several types of...

Ngày tải lên: 02/11/2012, 09:51

... necessary. As it will be discussed below, histological assessment is very valuable in determining HBV treatment in patients with persistently normal transaminases. ALT Levels For many years, ... challenge remains in optimizing HBV therapy. First, further understanding HBV dynamics and correlation of the level of HBV replication with liver injury will be invaluable for us to defi...

Ngày tải lên: 03/11/2012, 09:41

... semi-supervised systems for initial training. We use the seed data only in our semi-supervised system, and not in the unsupervised system. The reference data is a small subset of the training data which ... translit- eration model to incorrectly learn non-transliteration informa- tion from the training data. 471 Proceedings of the 50th Annual Meeting of the Association for Computati...

Ngày tải lên: 19/02/2014, 19:20

... measurement points. All the experiments were performed in triplicate yielding TAPA, i.e. CatE and CatD activity. Aspartic proteinase activity could be completely inhibited using 1 lL1mm pepstatin A solution ... (recombinant) was completely immunoprecipitated by the antibody against CatE (Fig. 4A), whereas it had almost no effect on CatD activity (Fig. 4B). This approach for depleting pr...

Ngày tải lên: 07/03/2014, 09:20

... Workshop on Language Engineering, Center for Language and Speech Processing, Johns Hopkins University. Any opinions, findings, and conclusions or recom- mendations expressed in this material are ... the highest probabil- ity tree for a sentence is achieved using a CKY-style parsing algorithm. 4 Parsing the Czech PDT Many statistical parsing methods developed for En- glish us...

Ngày tải lên: 08/03/2014, 06:20

... These methods typically rely on informa- tion that is unknown in a typical deciphering sce- nario (while being readily available for living lan- guages). For instance, some methods employ a hand-coded ... instead of summing over the values in Equation 2, we instead sample from them. 6.2 Sampling Sparsity Indicators Recall that each sparsity indicator λ e determines the value of the...

Ngày tải lên: 17/03/2014, 00:20

... and metonymy processing sys- tems: everything from hand-coded rule-based sys- tems to statistical systems trained on large cor- pora. Rule-based systems – some using a type of interlingua (Russell, ... hungering for safety and high yields are pouring record sums into single- premium , interest-earning annuities ./. *literal cluster* wsj59:3286 L Custom demands that cognac be poured fr...

Ngày tải lên: 24/03/2014, 03:20