Intraocular Drug DelIvery - part 8 pdf

... resorption, and downregulate inflam- matory mediators [including interleukin (IL )-5 , IL-6, IL -8 , prostaglandins, inter- feron-gamma (IF-g), tumor necrosis factor-alpha]. Corticosteroids stabilize ... release over a longer period. Delivery of co-drugs, dexamethasone–5-FU as an implantable, sustained-release pellet, and triamcinolone–5-FU as injectable intravitreal sustained-release susp...

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... Probes as Sustained-Release Drug Delivery Systems . . . . 216 Microelectromechanical Systems Drug Delivery Devices . . . . 219 References . . . . 222 PART III: LOCAL DRUG DELIVERY APPROACH TO ... mechanisms by which drugs are cleared, and drug delivery for some specific ophthalmic problems. BASIC PRINCIPLES OF DRUG DELIVERY Delivery Rates As a means to predict the propert...

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... Ophthalmol 1 981 ; 91: 184 – 189 . 131. McCullen BW, Bessler M, Tano Y, et al. The lack of toxicity of intravitreally adminis- tered triamcinolone acetonide. Am J Ophthalmol 1 981 ; 91: 785 – 788 . 132. Chandler ... Cell 2004; 15: 176– 188 . 76. Carrasquillo KG, Ricker JA, Rigas IK, Miller JW, Gragoudas ES, Adamis AP. Con- trolled delivery of the anti-VEGF aptamer EYE001 with poly(lactic-co...

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... oid (anti-inflam matory) or mineralocor ticoid (salt retaining) activity, and was intro duced in 1 985 (56). The formula of anecortave acetate is 4,9(11)-pregnadien-17,21-diol-3,20-dione-21-acetate. ... intravitreal drug levels. Pharmacokinetic studies are important in the development of local ocular drug delivery. Although a benefit of ocular drug delivery is the ability to achieve hi...

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... Effect of NT-501 on Photoreceptors of rcd1 Dogs Animal # Retina area à Photoreceptor ONL p-value ECT-CNTF treated Not treated 1 485 S1 5.5 3.0 S2 5 .8 2.7 S3 6.0 4.0 I1 4.0 2.5 I2 3 .8 2.3 I3 4.2 ... cell therapy-based NT-501 intraocular devices. Tissue Eng 2004; 10(11/12):1617–1622. 1 28 Tao et al. from minimal swelling to more pronounced vacuolization and disarray. The lower drug dos...

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... (single- stranded) 4 .8 kb RPE; photorecep- tors (11,14, 18) þþþ ( > 3 yr) Humoral 2,3-Sialic acid ( 18, 19) NR AAV; serotype 1 DNA (single- stranded) 4 .8 kb RPE cells, cone photorecep- tors (11,14, 18) þþþ ... Opportunities in drug delivery. Drugs 1997; 54(suppl 4) :8 14. 32. Mayhew E, Ito M, Lazo R. Toxicity of non -drug- containing liposomes for cultured human cells. Exp Cell Re...

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... of intraocular gas on intravitreal drug concentrations using a nondegradable sustained-release device con- taining fluocinolone and 5- uorouracil (27). Intraocular drug concentrations over a 6-week ... Ophthal- mol Vis Sci 2003; 44:740–744. 24. Ahmed I, Patton TF. Importance of the noncorneal absorption route in topical ophthal- mic drug delivery. Invest Ophthalmol Vis Sci 1 985 ;...

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... 1 984 :81 –105. 48. Waga J, Ehringer B. Passage of drugs through different intraocular microdialysis mem- branes. Graefes Arch Clin Exp Ophthalmol 1995; 233:31–37. 49. Waga J, Ohta A, Ehinger B. Intraocular ... 1 988 ; 106:254–259. 56. Ben-Nun J, Cooper RL, Cringle SJ, Constable IJ. A new method for continuous intrao- cular drug delivery. Aust N Z J Ophthalmol 1 989 ; 17: 185 –190. 57...

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... toxicity of intra- vitreally administered triamcinolone acetonide. Am J Ophthalmol 1 981 ; 91: 785 – 788 . 18. Schindler RH, Chandler DB, Thresher R, Machemer R. The clearance of intravitreal tri- macinolone ... (n ¼ 78 eyes), 42 eyes were available for follow-up at the three-year visit. Of these eyes, 10 (24%) gained two or more lines of visual acuity at the three-year follow-up. Twenty ey...

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... 72–73 Anti-CMV treatment, 325, 334, 343 Antifungals, 93 Antimicrobials administration of, 88 betalactam, 87 characteristics of, 91–93 therapy, 3 48, 351 Antimicrobials multiple, 88 Aphakic-vitrectomized ... 312 Plasminogenactivator inhibitor-1 (PAI-1), 80 Platelet-activating factor (PAF), 306 Platelet-derived growth factor (PDGF), 29, 33, 72, 306 Pneumatic retinopexy, 98 99, 1 08 Pol...

Ngày tải lên: 09/08/2014, 20:22