Intraocular Drug DelIvery - part 7 pps

... with 4-week follow-up before any retreatment No. with 12-week follow-up before any retreatment 1 6 10 50, 75 , 100, 150 30 a 22 22 19 b 2 6 10 50, 75 , 100, 150 20 37 28 c 17 d 3 12 10 50, 75 , 100, ... orally effective beta-isoform-selective inhibitor. Diabetes 19 97; 46:1 473 –1480. 16. Robinson MR, Yuan P, Sung C, Nussenblatt RB, Whitcup SM. Sustained-release deliv- ery system for a...

Ngày tải lên: 09/08/2014, 20:22

... Probes as Sustained-Release Drug Delivery Systems . . . . 216 Microelectromechanical Systems Drug Delivery Devices . . . . 219 References . . . . 222 PART III: LOCAL DRUG DELIVERY APPROACH TO ... mechanisms by which drugs are cleared, and drug delivery for some specific ophthalmic problems. BASIC PRINCIPLES OF DRUG DELIVERY Delivery Rates As a means to predict the propert...

Ngày tải lên: 09/08/2014, 20:22

... of intraocular gas on intravitreal drug concentrations using a nondegradable sustained-release device con- taining fluocinolone and 5- uorouracil ( 27) . Intraocular drug concentrations over a 6-week ... in rabbit sclera after treatment with 7- methylxanthine, theobromine, acetazo- lamide, or l-ornithine. Br J Ophthalmol 1999; 83:1 370 –1 375 . Transscleral Drug Delivery to the...

Ngày tải lên: 09/08/2014, 20:22

... carbamazepine, and barbiturates, are frequent. Other drugs causing this syndrome include lamotrigine, Chapter 056. Cutaneous Drug Reactions (Part 7) FIXED DRUG ERUPTIONS These reactions are characterized ... Initially described with phenytoin, hypersensitivity syndrome—a multiorgan drug- induced reaction—is also known as DRESS and drug- induced hypersensitivity syndrome (DI...

Ngày tải lên: 07/07/2014, 01:20

... and ZO-1 in cultured cells. J Biol Chem 2002; 277 : 27, 7 57 27, 764. 33. Cordenonsi M, D’Atri F, Hammar E, et al. Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, ... Con- trolled delivery of the anti-VEGF aptamer EYE001 with poly(lactic-co-glycolic)acid microspheres. Invest Ophthalmol Vis Sci 2003; 44:290–299. 77 . Qaum T, Xu Q, Joussen AM, et al. V...

Ngày tải lên: 09/08/2014, 20:22

... oid (anti-inflam matory) or mineralocor ticoid (salt retaining) activity, and was intro duced in 1985 (56). The formula of anecortave acetate is 4,9(11)-pregnadien- 17, 21-diol-3,20-dione-21-acetate. ... Science 19 87; 235( 478 7):442–4 47. 19. Kang BS, Chung EY, Yun YP, et al. Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity. Biol Pharm Bull 2001; 24(6) :70 1 70 3. A...

Ngày tải lên: 09/08/2014, 20:22

... INS 372 17 versus vehicle on retinal detachment in a rat model of induced nonrhegmatogenous retinal detachment. INS 372 17 (5 mM) was administered as a 3-mL intravitreous injection. INS 372 1 7- containing solution ... INS 372 17 ( 3 H-INS 372 17 at 3 mg per eye) showing the distribution of radiolabeled signal in various ocular structures at the postinjection time points indicated. Radioa...

Ngày tải lên: 09/08/2014, 20:22

... Opportunities in drug delivery. Drugs 19 97; 54(suppl 4):8–14. 32. Mayhew E, Ito M, Lazo R. Toxicity of non -drug- containing liposomes for cultured human cells. Exp Cell Res 19 87; 171 :195–202. Thermal-Sensitive ... virus and adenovirus receptor (7) a v integrin (7) Adenovirus (Ad3-based vectors) (8) DNA 7. 5 kb Ciliary body; iris, inner retina !7 days þþ Cellular NR Adenovirus (Ad3...

Ngày tải lên: 09/08/2014, 20:22

... resorption, and downregulate inflam- matory mediators [including interleukin (IL )-5 , IL-6, IL-8, prostaglandins, inter- feron-gamma (IF-g), tumor necrosis factor-alpha]. Corticosteroids stabilize ... noncomparative interventional case Intraocular Sustained-Release Devices in Uveitis 271 series of a sustained-release (24) drug delivery device containing fluocinolone aceto- nide to tre...

Ngày tải lên: 09/08/2014, 20:22

... Trans Am Ophthalmol Soc 1 979 ; 77 : 171 – 178 . 26. Antoszyk AN, Gottlieb JL, Machemer R, Hatchell DL. The effects of intravitreal triam- cinolone acetonide on experimental pre-retinal neovascularization. ... endothelial growth factor by platelet-activating factor and platelet-derived growth-factor is downregulated by corti- costeroids. Am J Resp Cell Mol Biol 19 97; 16:398–406. 17. McCuen...

Ngày tải lên: 09/08/2014, 20:22