Intraocular Drug DelIvery - part 4 pptx

... Effect of NT-501 on Photoreceptors of rcd1 Dogs Animal # Retina area à Photoreceptor ONL p-value ECT-CNTF treated Not treated 148 5 S1 5.5 3.0 S2 5.8 2.7 S3 6.0 4. 0 I1 4. 0 2.5 I2 3.8 2.3 I3 4. 2 2.7 Average ... et al. Levobetaxolol-induced up-regulation of retinal bFGF and CNTF mRNAs and preservation of retinal function against a photic-induced retinopathy. Exp Eye Res 2002; 74: 445 45...

Ngày tải lên: 09/08/2014, 20:22

... Opportunities in drug delivery. Drugs 1997; 54( suppl 4) :8– 14. 32. Mayhew E, Ito M, Lazo R. Toxicity of non -drug- containing liposomes for cultured human cells. Exp Cell Res 1987; 171:195–202. Thermal-Sensitive ... (single- stranded) 4. 8 kb RPE; photorecep- tors (11, 14, 18) þþþ ( > 3 yr) Humoral 2,3-Sialic acid (18,19) NR AAV; serotype 1 DNA (single- stranded) 4. 8 kb RPE cells...

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... information. 348 ch 04. qxd 8/13/2001 1 :46 PM Page 348 360 ␤-ADRENERGIC BLOCKING DRUGS COMPARISON CHART (continued ) β HALF- EXCRETED DOSAGE CARDIO- LIFE UNCHANGED PROTEIN LABELED STARTING MAXIMUM DRUG ... 3–8 24 2–9 b Hepatic, Renal. Univasc Perindopril Tab 2, 4, 8 mg. 4 8 No 3–7 24+ 3–10 b Renal. Aceon Quinapril Tab 5, 10, 20–80 Yes 2 4 24+ 2–3 b Renal. Accupril 20, 40 mg. (conti...

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... Probes as Sustained-Release Drug Delivery Systems . . . . 216 Microelectromechanical Systems Drug Delivery Devices . . . . 219 References . . . . 222 PART III: LOCAL DRUG DELIVERY APPROACH TO ... mechanisms by which drugs are cleared, and drug delivery for some specific ophthalmic problems. BASIC PRINCIPLES OF DRUG DELIVERY Delivery Rates As a means to predict the propert...

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... phosphoinositide 3 kinase (PI3-K) (43 ,44 ). PI3-K, in turn, activates a serine–threonine protein kinase, Akt, that phosphorylates Bad (45 47 ) and promotes its associati on with the 1 4- 3 -3 protein family (29). ... 2000; 41 :40 1 42 1. 123. Lau D, McGee LH, Zhou S, et al. Retinal degeneration is slowed in transgenic rats by AAV-mediated delivery of FGF-2. Invest Ophthalmol Vis Sci 200...

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... oid (anti-inflam matory) or mineralocor ticoid (salt retaining) activity, and was intro duced in 1985 (56). The formula of anecortave acetate is 4, 9(11)-pregnadien-17,21-diol-3,20-dione-21-acetate. ... factors. Science 1987; 235 (47 87) :44 2 44 7. 19. Kang BS, Chung EY, Yun YP, et al. Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity. Biol Pharm Bull 2001; 24( 6):701...

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... Ophthal- mol Vis Sci 2003; 44 : 740 – 744 . 24. Ahmed I, Patton TF. Importance of the noncorneal absorption route in topical ophthal- mic drug delivery. Invest Ophthalmol Vis Sci 1985; 26:5 84 587. 25. ... Microsc (Tokyo) 1995; 44 :44 5 44 9. 13. Marshall GE, Konstas AG, Lee WR. Collagens in the aged human macular sclera. Curr Eye Res 1993; 12: 143 –153. 14. Komai Y, Ushiki T. The thre...

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... more was seen in 44 % of treated and 45 % of control eyes at 12 mon ths, and 52% versus 56% at 24 months (P ¼ 0.58). However, a significant benefit at both 1 2- and 2 4- month follow-up was seen for ... neovascularization: an in-vitro analysis. Invest Ophthalmol Vis Sci 1999; 40 :S 84 (Abstract no 44 8). 6. Jaffe GJ, Yang C-S, Wang X-C, Cousins SW, Gallemore RP, Ashton P. Intravitreal...

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... resorption, and downregulate inflam- matory mediators [including interleukin (IL )-5 , IL-6, IL-8, prostaglandins, inter- feron-gamma (IF-g), tumor necrosis factor-alpha]. Corticosteroids stabilize ... 1989; 107:1 147 –1151. 4. Girard P, Mimoun G, Karpouzas I, Montefiore G. Clinical risk factors for proliferative vitreoretinopathy after retinal detachment surgery. Retina 19 94; 14: 417 42 4...

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... 78 eyes), 42 eyes were available for follow-up at the three-year visit. Of these eyes, 10 ( 24% ) gained two or more lines of visual acuity at the three-year follow-up. Twenty eyes (48 %) remained ... American incidence of CMV retinitis in the post-HAART era has decreased to approximately one-fourth that of the pre-HAART era (4, 24 27). The CD4þ lymphocyte cell count continues to be a reliab...

Ngày tải lên: 09/08/2014, 20:22