Báo cáo y học: "Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites" potx

... polyribosome occu- panc y and translation rates. microRNA target specificity may vary substantially between organisms, given the diversity of RNAi pathways and the different constitu- ents of ... Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites. Genome Biology 2010 11:R90. Submit your next manuscript to BioMed C...

Ngày tải lên: 09/08/2014, 20:22

... lipoprotein lipase and functional studies of the carboxyl-terminal domain Yoko Kobayashi, Toshiaki Nakajima and Ituro Inoue Division of Genetic Diagnosis, Institute of Medical Science, The University of Tokyo, ... gastric lipase, and endothelial lipase [1,2]. The primary function of LPL is triglyceride hydrolysis in triglyceride-rich lipoproteins, such as chylomicron and v...

Ngày tải lên: 21/02/2014, 15:20

... NW, Calgary, AB T2N 2T9, Canada 2 Department of Community Health Sciences, University of Calgary, Calgary, AB T2N 2T9, Canada 3 Department of Medicine, University of Calgary, Calgary, AB T2N ... responsibility for the integrity of the data and the accuracy of the analysis. References 1. Himmelstein DU, Jones AA, Woolhandler S: Hypernatremic dehydration in nursing home patients:...

Ngày tải lên: 25/10/2012, 10:31

... of the enthalpy and entropy changes, DH mean and DS mean , are simply given by: DH mean ¼ P m i ¼ 1 DH i n ð9Þ DS mean ¼ P m i ¼ 1 DS i n ð10Þ where DH i and DS i are the enthalpy and entropy ... thermodynamic properties of the duplex formation determined by DC P ¼ 0and DC P 6¼ 0 were extensively discussed and compared. The compensation of the temperature-dependent enthalpy...

Ngày tải lên: 22/02/2014, 07:20

... We Thank Prof B. Bhattacharyya, Bose Institute, Kolkata and Prof U. Chowdhury, University of Calcutta for their suggestions and various helps. We also thank Dr B. Sanyal, Department of Physics, Uppsala ... dehydrogenase Equilibrium and kinetic studies Suparna C. Sanyal 1 , Debasish Bhattacharyya 2 and Chanchal Das Gupta 1 1 Department of Biophysics, Molecular Biology and Genet...

Ngày tải lên: 08/03/2014, 23:20

... 1). Our understanding of the catalytic mechanism of DAOCS [8–10] has been significantly advanced by the determination of the crystal structure of wild-type and mutant DAOCS with various ligands [1,11–13]. ... Taiwan; 3 Department of Pharmacy and Pharmacology, The University of Bath, UK Deacetoxycephalosporin C synthase (DAOCS) catalyses the oxidative ring expansion of penicil...

Ngày tải lên: 18/03/2014, 01:20

... endocrine diseases, Fig.3.Assessmentof11b-h ydroxylase a ctivity and determination of 11b-hydroxylase capacity. (A)Assessmentof11b-hydroxylase activity of CYP11B2 var iants e xpressed i n COS-1 ... Determination of 11b-hydroxylase capacity of CYP11B2 mutants in relation to the wild-type enzyme, when incubated with 11-deoxycortisol. The 11b-hydroxylation of 11-deoxycortisol catalys...

Ngày tải lên: 24/03/2014, 03:21

... recently shown to provide very high coding efficiency and to enable complete spatiotemporal, SNR, and complex- ity scalability [4, 5, 6]. Apart from the flexibility introduced by the scalability of ... probability law of the coefficients given by (5 )and (6), it can be easily shown that this criterion satisfies relation (8) (with equality if and only if θ = θ 0 ), but condition (9) holds...

Ngày tải lên: 23/06/2014, 01:20

... A recent study of 13 years of follow-up of early onset schiz- ophrenia reported acute schizophrenic symptoms in 22.2% of patients and depression symptoms in 30.8% of patients [9]. The same study revealed ... concepts of remission and recovery in schizophrenia. Pharmacopsychiatry 2006, 39:161-170. 55. Lindström E, Eberhard J, Levander S: Five-year follow-up during antipsychotic...

Ngày tải lên: 08/08/2014, 23:21

... gender, and education. This propensity score can then be used for ‘adjusting’ for the effect of confounders by matching, by stratification, and by regres- sion models. However, propensity scores ... superiority of the new drug 43 physician-based measures [11], the practicalities of mea- surement, analysis, and interpretation raise several issues. Longitudinal observational studies...

Ngày tải lên: 09/08/2014, 01:23