Báo cáo y học: "Intronic motif pairs cooperate across exons to promote pre-mRNA splicing" docx

... likely to be highly correlated due to the existence of GC isochores in the human genome, we need to apply a strategy to remove this bias. Toward this end we grouped exons twice, first into 20 ... genome. The discovery of particular significantly correlated intronic motif pairs located close to splice sites suggests that they may be working cooperatively across exons to p...

Ngày tải lên: 09/08/2014, 20:22

... Specifically; tacro- limus is mainly metabolized by CYP3A4 and CYP3A5 enzyme isotype. CYP3A5 polymorphisms seem to affect tacrolimus kinetics at a greater degree com- pared to CYP3A4 ones and thereby, ... factors known to affect pharmacokinetics are the drug transporters and the metabolizing en- zymes [7,9]. CYP3A, the primary subfamily of the cytoch- rome P450 (CYP) enzymatic syst...

Ngày tải lên: 26/10/2012, 09:32

... Center, Nagoya University, Nagoya, Japan to seek H. pylori tests and eradication between July 2004 and October 2005. The visitors aged 20 to 69 years were asked to participate in the polymorphism ... University from July 2004 to October 2005. The participants aged 20 to 69 years were classified into three group according to CYP2C19 genotype; rapid metabolizers (RM) with *1*1...

Ngày tải lên: 31/10/2012, 16:57

... common denominator in every influenza outbreak was its ability to follow the travel routes from city to city and sicken large numbers quickly and killing the very young and very old. The association ... the “1918 type”, and or the conditions necessary to prevent the reappearance of this influenza. Unlike the typical “flu” that strikes the very young, chronically ill and elderly;...

Ngày tải lên: 02/11/2012, 11:12

... 2002 by a s ynthetic phase cytosol (Fig. 6A, column 9 ). T hese results suggested that a kinase(s) in the synthetic phase egg cytosol fraction phosphorylates NK at a functionally similar site(s) to ... chromatin by phosphorylation by a kinase(s) in a synthetic phase egg cytosol Chromatin binding of beads bearing GST–NK was incr- eased by pretreatment w ith a synthetic phase egg cytosol frac...

Ngày tải lên: 22/02/2014, 04:20

... heart, the 28-kDa Rab32 appeared to be completely replaced by a protein corresponding to Rab32L. Although we cannot yet exclude the possibility that the antibody to Rab32 detects an u nrelated ... coupled to keyhole limpet haemocyanin via their endogenous (Rab31) or added (Rab32, Rab11A) cysteine residues, using 4-(N-maleimidomethyl) cyclohexane-1-carboxylate. Rabbits were immunized b...

Ngày tải lên: 08/03/2014, 16:20

... on dystrobrevin (Dyb-1) by performing deletion-mapping experiments in vitro.Wethen tested the ability of t he truncated Dyb-1 proteins to bind to dystrophin (Dys-1) in a yeast two-hybrid assay, ... activity (clones 2¢5and5¢2B) were unable to promote Dys-1–Dyb-1 interaction in the yeast two-hybrid system, which indicates that the yeast assay i s more selective than the in v itro assay....

Ngày tải lên: 08/03/2014, 23:20

... Verger 1 1 Laboratoire de Lipolyse Enzymatique CNRS-IFR1, Marseille, France; 2 Structural Biology Laboratory, Chemistry Department, University of York, UK; 3 Enzyme Research, Novozymes A/S, Bagsvaerd, ... previously to study the binding of TLL to small or large unilamellar vesicles of 1-palmitoyl-2-oleoylglycero-sn-3-phosphoglycerol (POPG) and to vesicles of zwitterionic phospholipids s...

Ngày tải lên: 08/03/2014, 23:20

... xtends to the stimulation of pulmonary artery fibroblasts, with both enzymes able to induce DNA synthesis over a similar concentration range. As soybean t rypsin inhibitor was able to completely inhibit the ... How- ever, trypsin-induced MAPK activation was reported to occur independently of PAR2 in bovine pulmonary artery fibroblasts [34]. Inflammatory cytokines have previously been sho...

Ngày tải lên: 24/03/2014, 03:21

... mechanism for enzymatic hydrogen transfer. Biophys. J. 63, 689–699. 15. Kuznetsov, A.M. & Ulstrup, J. (1999) Proton and hydrogen atom tunnelling in hydrolytic and redox enzyme catalysis. Can. J. ... effects are required to accommodate the kinetics of SLO, and may be equally important in many other hydrogen atom transfer reactions. Many H• transfer reactions are characterized by very lar...

Ngày tải lên: 31/03/2014, 23:20