Báo cáo y học: " Contrasting chromatin organization of CpG islands and exons in the human genome" pot

... downstream of the exon) for the absolute and relative exonic enrichment of CpG methylation. CpG islands, exons, and CpG density The genomic coordinates of CGIs and exons were down- loaded from the UCSC ... number of intact cytosines and the total number of intact and bisulfite-converted cytosines was calculated for each locus to indicate the degree o...

Ngày tải lên: 09/08/2014, 20:22

... since the 13-mer motif occurs in only about 40% of human hotspots [32] and the variation in the zinc finger array of the Prdm9 gene can expl ain only about 18% of varia- tion in human recombination ... of the segment. The recombination activity of a hotspot, also called hotspot ‘strength’, was then measured by the sum of recombination activities of the...

Ngày tải lên: 09/08/2014, 22:23

... length of stay (LOS) in a mixed medical– cardiac ICU [2]. Onset of AF in a patient in the surgical ICU increases their LOS in the ICU and in the hospital [11,16,32,33,39,40]. Onset of AF reduces the ... contraction, by irregularity of ventricular contraction [43], by inadequate filling time for the left ventricle due to tachycardia, and by tachycardiomyopathy [...

Ngày tải lên: 25/10/2012, 10:35

... enhancement in the frequency of arthritis in the T cell-deficient mice and the B cell-defi- cient mice suggest that these cells might play regulatory roles in the initiation of disease. Effect of T ... reactivity of the clonally distinct glycopeptide-reactive T cells [7]. To investigate the role of T cells in the acute effector stage of clinical arthritis,...

Ngày tải lên: 09/08/2014, 01:24

... OX35, and RIB5/2 (on days –1, 0, 3, and 6, i.e. 1 day before AA induction, on the day of induction [day 0], and thereafter). The effects on T-cell reactivity in vivo (delayed-type hypersensitivity), ... individual proinflammatory functions of T cells. This fine regulation may explain the differential efficacy in the treatment of AA and may contribute to the underst...

Ngày tải lên: 09/08/2014, 03:24

... anti-inflamma- tory action of statins in RA. The combined effects of DAF, at the level of C3 and C5 convertases, and of CD59 inhibiting the terminal attack complex has the potential to exert anti- inflammatory ... demonstrated clinically apparent anti-inflammatory effects of statins in rodent models of inflammatory arthritis and in one model in patients with...

Ngày tải lên: 09/08/2014, 08:22

... original work is properly cited. Abstract The objective of this study was to analyse levels of the proinflammatory cytokine macrophage migration inhibitory factor (MIF) in patients with primary ... helper type 1 cytokine expression as well as B-lymphocyte hyperactivity leading to the production of circulating autoantibodies and hypergamma- globulinemia are hallmark characteris...

Ngày tải lên: 09/08/2014, 10:20

... sign of inflammation; 1, mild swelling or erythema or both; 2, moderate swelling and erythema; and 3, marked swelling and erythema. The arthritic index for each mouse was constructed by summing ... were used. All of the mice were maintained in the animal facility of the Department of Rheumatology and Inflammation Research, University of Gothenburg, Sweden, in acc...

Ngày tải lên: 09/08/2014, 14:22

... Figure 1, the majority of brain and nerve samples form adistinctgrouptogetherwithanumberofretinasam- ples. The retina and the optic nerve originate as out- growths of the developing brain and are ... of samples in individual species is well preserved in the multi-species analysis; more interestingly, human and mouse share a very simi- lar pattern of sample clus...

Ngày tải lên: 09/08/2014, 22:23

... study and performed the statistical analysis. ET and KDGD participated in the collection of the blood samples and conception of the study. RC and CB participated in its design and coordination and helped ... to HIV-1 infection risk through homosexual intercourse. The discrepancy between these results may be partially explained by the number of individuals inc...

Ngày tải lên: 10/08/2014, 05:20