Báo cáo y học: "Nuclear transcription factors in mammalian mitochondria" pdf

... copy number [32]. is complexity is likely to be shared by other transcription factors with a direct mitochondrial activity, and it may explain why early work did not detect direct binding ... followed by immunoblotting is highly dependent on antibody specificity. Indeed, one antibody used to detect the phosphorylated form of the cyclic- AMP response element binding protein (CREB) in...

Ngày tải lên: 09/08/2014, 20:22

... RA. Introduction Interleukin (IL)-17 may play a critical role in the pathogenesis of rheumatoid arthritis (RA). IL-17 is capable of promoting inflammation by inducing a variety of pro-inflammatory media- tors, ... function for transforming growth factor- beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nature Immunology 2008, 9:650-657....

Ngày tải lên: 09/08/2014, 10:23

... biological science community, chiefl y because they saw it as taking money and attention away from important fundamental research and channeling it into lower-quality, clinically oriented studies ... any new money to pay for it. So the money must come from somewhere, and the big fear among many in the scientifi c community is that it will come from the pool of individual investigato...

Ngày tải lên: 09/08/2014, 20:21

... Missing metabolic pathways revealed by the complete genome sequence of the uncultivated marine nitrogen-xing cyanobacterium UCYN-A. (a) Key metabolic pathways typically found in nitrogen-xing ... nitrogen-xing cyanobacteria. (b) Pathways found, as evidenced by gene content, in UCYN-A. Shaded-out areas with a red ‘X’ indicate pathways missing in UCYN-A. Cytb, cytochrome b complex; F...

Ngày tải lên: 09/08/2014, 20:21

... nuclear factors that bind specifically to MREa. Two MREa-binding proteins of 70 and 82 kDa were purified using avidin–biotin affinity chromatography. Amino acid sequences of peptides from each protein ... MREa-binding activity, which consisted of two polypeptides of approximately 70 and 82 kDa. N-terminal and internal amino acid sequencing and immuno analyses revealed that MREa-binding proteins...

Ngày tải lên: 17/03/2014, 23:20

... transcriptional activity of NRs. For example, Suv39H1 is a heterochroma- tin-associated, SET domain-containing protein with intrin- sic H3 lysine 9-specific HMT activity [51]. The methylation of H3 lysine 9 in nucleosomes ... use lysine-specific HMTs to actively repress transcription, however, remains to be determined. CHROMATIN MODIFYING ENZYMES AND THE ACTIVATION OF TRANSCRIPTION BY NRs...

Ngày tải lên: 31/03/2014, 21:21

... aneurysm repair in this study were female gender and active smoking. We did not find any difference in the prevalence of hypertension, hyperlipi- demia, or family history of any aortic aneurysm. ... [19-27]. Smoking plays important roles in mediating atherosclerosis, elastolytic response, and potentiating inflammation [28-30]. It affects key proteolytic enzymes like MMPs, elastases, cys...

Ngày tải lên: 09/08/2014, 13:22

... falciparum erythrocyte membrane protein 1 (PfEMP1) proteins, employed by the parasite to sequester in the microvasculature of various organs in the human host. This family, encoded by approximately 60 ... University, Husargatan 3, SE-751 21 Uppsala, Sweden. § Key Laboratory of Zoonosis, Ministry of Education, Jilin University, Xi An Da Lu 5333, Changchun 130062, China. ¶ Laboratory of...

Ngày tải lên: 09/08/2014, 20:20

... activity of MBD4 (methyl-CpG binding domain pro- tein 4), another thymine glycosylase involved in removing T/G mismatches [17]. Most studies in the field of active DNA demethylation are based on ... demethylation of the CYP27B1 gene, suggesting that cytosine deamination may not necessarily be required for demethylation [17]. Another study argued for a model in which the TATA box binding...

Ngày tải lên: 09/08/2014, 20:22

... 7:845-855. 5. Lin PL, Pawar S, Myers A, Pegu A, Fuhrman C, Reinhart TA, Capuano SV, Klein E, Flynn JL: Early events in Mycobacterium tuberculosis infection in cynomolgus macaques. Infect Immun 2006, 74:3790-3803. doi:10.1186/gb-2010-11-9-135 Cite ... latent infections are not binary but, instead, represent different ends of a continuum of disease [4]. is new paradigm of TB is largely...

Ngày tải lên: 09/08/2014, 22:23