Báo cáo y học: "Nuclear transcription factors in mammalian mitochondria" pdf
Báo cáo y học: "Nuclear transcription factors in mammalian mitochondria" pdf
... copy number [32]. is complexity
is likely to be shared by other transcription factors with a
direct mitochondrial activity, and it may explain why
early work did not detect direct binding ... followed by immunoblotting is highly
dependent on antibody specificity. Indeed, one antibody
used to detect the phosphorylated form of the cyclic-
AMP response element binding protein (CREB) in...
Báo cáo y học: "TH-17 cells in rheumatoid arthritis" pdf
... RA.
Introduction
Interleukin (IL)-17 may play a critical role in the pathogenesis
of rheumatoid arthritis (RA). IL-17 is capable of promoting
inflammation by inducing a variety of pro-inflammatory media-
tors, ... function for transforming growth factor-
beta, interleukin 23 and proinflammatory cytokines in driving
and modulating human T(H)-17 responses. Nature
Immunology 2008, 9:650-657....
Báo cáo y học: "The devil’s in the details" pdf
... biological science
community, chiefl y because they saw it as taking money
and attention away from important fundamental research
and channeling it into lower-quality, clinically oriented
studies ... any new
money to pay for it. So the money must come from
somewhere, and the big fear among many in the scientifi c
community is that it will come from the pool of individual
investigato...
Báo cáo y học: "nteresting things come in small packages" pdf
... Missing metabolic pathways revealed by the complete genome sequence of the uncultivated marine nitrogen-xing
cyanobacterium UCYN-A. (a) Key metabolic pathways typically found in nitrogen-xing ... nitrogen-xing cyanobacteria. (b) Pathways found, as evidenced by
gene content, in UCYN-A. Shaded-out areas with a red ‘X’ indicate pathways missing in UCYN-A. Cytb, cytochrome b complex; F...
Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt
... nuclear
factors that bind specifically to MREa. Two MREa-binding
proteins of 70 and 82 kDa were purified using avidin–biotin
affinity chromatography. Amino acid sequences of peptides
from each protein ... MREa-binding activity, which consisted
of two polypeptides of approximately 70 and 82 kDa.
N-terminal and internal amino acid sequencing and immuno
analyses revealed that MREa-binding proteins...
Báo cáo Y học: Nuclear receptor-dependent transcription with chromatin Is it all about enzymes? pot
... transcriptional
activity of NRs. For example, Suv39H1 is a heterochroma-
tin-associated, SET domain-containing protein with intrin-
sic H3 lysine 9-specific HMT activity [51]. The methylation
of H3 lysine 9 in nucleosomes ... use lysine-specific HMTs to actively
repress transcription, however, remains to be determined.
CHROMATIN MODIFYING ENZYMES
AND THE ACTIVATION
OF TRANSCRIPTION BY NRs...
Báo cáo y học: "Cardiovascular risk factors and acute-phase response in idiopathic ascending aortitis: a case control study" pptx
... aneurysm repair in this
study were female gender and active smoking. We did not find
any difference in the prevalence of hypertension, hyperlipi-
demia, or family history of any aortic aneurysm. ... [19-27].
Smoking plays important roles in mediating atherosclerosis,
elastolytic response, and potentiating inflammation [28-30]. It
affects key proteolytic enzymes like MMPs, elastases, cys...
Báo cáo y học: "Simultaneous transcription of duplicated var2csa gene copies in individual Plasmodium falciparum parasites" potx
... falciparum erythrocyte membrane
protein 1 (PfEMP1) proteins, employed by the parasite to
sequester in the microvasculature of various organs in the
human host. This family, encoded by approximately 60 ...
University, Husargatan 3, SE-751 21 Uppsala, Sweden.
§
Key Laboratory of Zoonosis, Ministry of Education, Jilin University, Xi An Da Lu 5333,
Changchun 130062, China.
¶
Laboratory of...
Báo cáo y học: "Active DNA demethylation in human postmitotic cells correlates with activating histone modifications, but not transcription levels" ppt
... activity of MBD4 (methyl-CpG binding domain pro-
tein 4), another thymine glycosylase involved in removing
T/G mismatches [17].
Most studies in the field of active DNA demethylation
are based on ... demethylation of
the CYP27B1 gene, suggesting that cytosine deamination
may not necessarily be required for demethylation [17].
Another study argued for a model in which the TATA box
binding...
Báo cáo y học: "Host transcription in active and latent tuberculosis" ppsx
... 7:845-855.
5. Lin PL, Pawar S, Myers A, Pegu A, Fuhrman C, Reinhart TA, Capuano SV, Klein E,
Flynn JL: Early events in Mycobacterium tuberculosis infection in
cynomolgus macaques. Infect Immun 2006, 74:3790-3803.
doi:10.1186/gb-2010-11-9-135
Cite ... latent
infections are not binary but, instead, represent different
ends of a continuum of disease [4]. is new paradigm of
TB is largely...