Báo cáo y học: "ar evolution of genes in avian genomes" doc

... number of REB, MREB and PS genes in different avian lineages Ancestral lineage Chicken lineage Zebra finch lineage Rapidly evolving bird (REB) genes 419 1,148 1,202 More rapidly evolving genes in ... Details 1 Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvägen 18D, Uppsala, S-752 36, Sweden, 2 Institute for Genomic Biology, Unive...

Ngày tải lên: 09/08/2014, 20:22

... 2002 introns in the evolutionary pathway to c-type genes, but rather the acquisition of an interdomain intron in the evolution of c-crystallins, and of both interdomain and intermotif introns in the evolution ... in favour of a late insertion of introns in crystallin-type genes, as opposed to a late deletion of pre-existing introns, may be based on the intron-late...

Ngày tải lên: 24/03/2014, 04:21

... models of autoimmu- nity [1,2]. Recently convincing proof of this hypothesis has been provided by the association of the missense single nucle- otide polymorphism (SNP; rs2476601) in the protein tyrosine phosphatase ... box- binding protein (TBP) amongst others. The aim of this study was to fine map the IDDM8 region on chromosome 6q27, focusing on the genes in the region, to ide...

Ngày tải lên: 09/08/2014, 08:22

... the MRI findings of the natural evolution of desmoid tumors. Desmoid tumors showing high SI on T2-weighted images tend to increase in size. Subse- quently, they show an increase in areas of low ... linically, however, changes in MRI findings provide important information in distin- guishing between aggressive and slow-growing tumors. Conclusion This case study has described th...

Ngày tải lên: 11/08/2014, 00:23

... enhanced in 1% copper sulphate for 10min. Finally, sections were counterstained in Mayer’s haematoxylin, dehydrated through the as- cending graded alcohols, cleared in xylol and finally coverslipped ... feature of various cancers including cancer of the co- lon [33]. The amino acid analysis of the purified mucin gave high amounts of ‘mucin-like amino acids, serine, threoni...

Ngày tải lên: 26/10/2012, 10:03

... Biochemistry of the Charité, Berlin, Germany using the ABI PRISM Big Dye Terminator system (Applied Biosystems, Germany). Sequences were analyzed using the Chromas software (Technely- sium Pty Ltd, ... individuals. Interestingly, this SNP had not yet been registered in any SNP databases despite of its high frequency of 20% in samples of patients with AML and 13,7% in health...

Ngày tải lên: 31/10/2012, 16:49

... against Cirrhosis), is a multicenter study of the potential benefit of prolonged peginterferon therapy in mitigating the progression of fibrotic liver disease. [8] In this study, 391 of the ... factors, specifically G-CSF and erythropoietin, has allowed more aggressive dosing of interferon and ribavirin. [13, 14] Finally, growing experience with antiviral therapy in thi...

Ngày tải lên: 31/10/2012, 17:11

... constants. Binding assays Binding affinity of TMP for the enzymes was measured by monitoring the quenching of tryptophan absorbance of the enzyme (ex 280 nm, em 345 nm) as increasing amounts of TMP ... was measured by calculating the proportion of initial velocity remaining after heating as a proportion of the initial velo- city of the nonincubated enzyme. MIC assays To determine...

Ngày tải lên: 19/02/2014, 02:20

... determinant for the transcrip- tional regulation of the drug metabolizing enzyme family of heme-containing monooxygenases P450 CYP3A [1–4]. Consequently this nuclear receptor is likely to play a ... the histidine residue makes a hydrogen bond to SR12813 in one of its binding modes. The mutation of this residue gave a number of surprising results suggesting that this residue play a...

Ngày tải lên: 08/03/2014, 16:20

... to ligation of the thiol group of coenzyme M. Mutations in His237 or Cys239, which are proposed to be involved in ligating zinc, resulted in an over 90% loss in enzyme activity and in distinct changes in ... & Penner-Hahn, J.E. (1998) Characterization of the zinc binding site in methionine synthase enzymes of Escherichia coli – the role of zinc in the methylation...

Ngày tải lên: 17/03/2014, 23:20