Báo cáo y học: "Detection and analysis of alternative splicing in Yarrowia lipolytica reveal structural constraints facilitating nonsense-mediated decay of intron-retaining transcripts" ppt

... is properly cited. Research Detection and analysis of alternative splicing in Yarrowia lipolytica reveal structural constraints facilitating nonsense-mediated decay of intron-retaining transcripts Meryem ... exists in Y. lipolytica, but some effectors are lacking The presence and efficiency of NMD was investigated in Y. lipolytica. Homologs of UP...

Ngày tải lên: 09/08/2014, 20:22

... granted by the Ethics Committee of the London School of Hygiene & Tropical Medicine and by the Ministry of Health of the Republic of Trinidad & Tobago. All participants provided informed ... disease activity and comorbidity in Trinidad. Furthermore, termination of pregnancy is currently illegal in Trinidad and therefore is likely to have been misreported as misca...

Ngày tải lên: 09/08/2014, 10:22

... a disintegrin and metallopeptidase domain (ADAM) 1, 3, 5, and 26 - have the metalloendopeptidase activity. Pro- tein domain analysis shows that two Pfam domains - reprolysin family propeptide and ... human lineage. Conclusions: This analysis of unitary pseudogenes provides insights into the evolutionary constraints faced by different organisms and the timescales of functiona...

Ngày tải lên: 09/08/2014, 20:21

... in that region. SNPs and insertions/deletions (indels) are valuable for many reasons, including genotyping, evolutionary analysis, and the relation of genotype to phenotype [18,41,42]. For example, ... assembly. Kelley and Salzberg Genome Biology 2010, 11:R28 http://genomebiology.com/2010/11/3/R28 Page 6 of 11 visually inspected and, in most cases, one copy was removed [38]....

Ngày tải lên: 09/08/2014, 20:21

... Coloproctology, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK. 4 Department of Clinical Neurological Sciences, Royal College of Surgeons in Ireland, Dublin 2, Ireland. 5 School ... Hospital and Trinity College Dublin, Beaumont Road, Dublin 9, Ireland. 8 School of Agriculture, Food Science and Veterinary Medicine, University Col...

Ngày tải lên: 09/08/2014, 22:23

... histidine. The serine/threonine protein phosphatases type 1, t ype 2 A a nd type 2C, in contrast, a re highly active against phosphohistidine in histone H4 (reviewed in [1]). Intriguingly, none of ... appearance and disappearance of phos- phohistidine on P-selectin are very rapid. The next finding of an intracellular signaling system involving histidine phosphorylation in mamma...

Ngày tải lên: 24/03/2014, 03:21

... structures, policy initiatives, or clinical concerns? Dev elopments in cancer research in the 1990s, including rapid advances in understanding of cancer genetics and increasing use of surface antigens ... Specifically, inter- citation analy sis in 1980 revealed tw o distinct domains, one focused on basic science and one on clinical oncol- ogy. By 2000 a distinct third domain h...

Ngày tải lên: 18/06/2014, 19:20

... understanding of cancer genetics and increasing use of surface antigens to characterize cell types, yielded a hybrid of applied and basic research with clear relevan ce for clinical oncol ogy. Cardiac ... Specifically, inter- citation analy sis in 1980 revealed tw o distinct domains, one focused on basic science and one on clinical oncol- ogy. By 2000 a distinct third domain had...

Ngày tải lên: 20/06/2014, 03:20

... abnormal central pain mechanisms to clinical FM pain include temporal summation of pain (or windup) and central sensitization. Review Biology and therapy of fibromyalgia: pain in fibromyalgia syndrome Roland ... pain sensitivity with spreading of hypersensitivity to uninjured sites and the generation of pain by low threshold mechano- receptors that are normally silent in pai...

Ngày tải lên: 09/08/2014, 08:22

... karyotypes by choosing only the first well-defined karyotype it contained. In case of multiple karyotypes from the same patient (’case’ in the Mitelman Database), only one karyotype was taken into ... directly linked to the full description of the relevant karyotypes in the Mitelman Database. Repeating the analysis without filtering ambiguities and selected karyotypes (yielding...

Ngày tải lên: 09/08/2014, 23:20