Báo cáo y học: "Active DNA demethylation in human postmitotic cells correlates with activating histone modifications, but not transcription levels" ppt

... activity of MBD4 (methyl-CpG binding domain pro- tein 4), another thymine glycosylase involved in removing T/G mismatches [17]. Most studies in the field of active DNA demethylation are based on ... properties in mitotic and postmitotic cell systems suggests that the active demethy- lation machinery may contribute to DNA methylation dynamics in both settings. Although the obse...

Ngày tải lên: 09/08/2014, 20:22

... was originally shown to be restricted to activated T lympho- cytes [5,22,23] and could be observed in resting T lym- phocytes, B lymphocytes, monocytes or granulocytes [20,24]. In contrast, Th2 lymphocytes ... patients (data not shown). Unexpectedly, in all samples inspected prominent staining for CXCR3 was found on scattered MCs within sublining layers and interstitial areas, as well...

Ngày tải lên: 09/08/2014, 01:23

... chromatin and thereby the DNA is exposed to highly reactive ROS which induce single strand breaks in the DNA. In cells, generally, these toxic effects are eliminated by repair enzymes. Poly-(ADP-ribose)-polymerases ... i f y defined DNA bands with 200, 400 and (600) bps as most prominent degradation products, presumably representing an internucleosomal DNA cleavage induc...

Ngày tải lên: 25/10/2012, 11:15

... between Cyt f and plastocyanin and/or plasto- cyanin and photosystem I, and subsequently the nature of the interactions in the two lineages (hydrophobic in cyanobacteria, electrostatic in chloroplasts) ... thermodynamic analysis by laser-flash absorption spectroscopy of photosystem I reduction by plastocyanin and cytochrome c 6 in Anabaena PCC 7119, Synechocystis PCC 6803, and spinach....

Ngày tải lên: 21/02/2014, 01:21

... GPVI, glycoprotein VI; PtdIns3K, phosphatidylinositol 3-kinase; PVDF, poly(vinylidene difluoride); PKC, protein kinase C; PP1, (4-amino-4-(4-methylphe- nyl)-7-(t-butyl)pyrazola[3,4-d]pyrimidine); ... Furthermore, these proteins can be activated independently, suggesting that each link is func- tional [5–7]. In addition, in megakaryocytic cell lines and in primary megakaryocytes, the prec...

Ngày tải lên: 08/03/2014, 16:20

... treated by clozapine or olanzapine, especially in the high body mass index (BMI) subgroup [3]. The purpose of this study is to assess binge eating symp- tomatology in a group of individuals receiving ... disorder and psychiatric comorbidity in obese subjects. Am J Psychiatry 1993, 150:1472-1479. 9. Telch CF, Agras WS: Obesity, binge eating and psychopathol- ogy: are they related? Int J...

Ngày tải lên: 08/08/2014, 21:20

... α. IL-1Ra increased significantly during the first year in both study groups, but the rise was not sustained until the end of the trial. One hypothesis to explain this finding is that vitamin D 3 , ... entry into the study and after 12 and 24 months, using vaginal ultrasonography and cytology. E 2 in serum was measured (approximately 12 hours after tablet intake) by radioimmunoassay (...

Ngày tải lên: 09/08/2014, 01:21

... incu- bated with Tris-buffered saline containing isotype-matched antibodies instead of the primary antibody; they were invar- iably negative (data not shown). The intensity of antibody staining ... might help in defining the role of these molecules in synovial inflammatory responses, offering new insights into elements controlling the immune response within joints. Competing interests...

Ngày tải lên: 09/08/2014, 06:22

... radiological scores at year (i + 1) versus the scores year (i) using the differences of year 2 minus year 1, of year 3 minus year 2, and of year 4 minus year 3; each subject therefore contributed to up ... was statistically significantly associated with the progression of the joint space narrowing score over the following year (for exam- ple, a relative increase of 6.4% in the joint space...

Ngày tải lên: 09/08/2014, 07:20

... accuracy of radiog- raphy was 0.95. Erosive disease (defined as presence of at least one erosion in the examined finger joints) was found in 13 patients with radiography, in 20 with MRI, and in 20 with ... ultrasonography (15 simultaneously with MRI). Eleven patients with erosions on radiography were identified as having erosions with MRI and nine with ultrasonography....

Ngày tải lên: 09/08/2014, 07:20