Báo cáo y học: "Dramatic changes in transcription factor binding over evolutionary time" pps

... Bradley RK, Li XY, Trapnell C, Davidson S, Pachter L, Chu HC, Tonkin LA, Biggin MD, Eisen MB: Binding site turnover produces pervasive quantitative changes in transcription factor binding between ... two point mutations (and not by insertions or deletions), suggesting that changes in TF occupancy are largely caused by the steady accumulation of small sequence changes [3]...

Ngày tải lên: 09/08/2014, 20:22

... of transcription factor binding sites by phy- logenetic footprinting. Genome Res 2004, 14:170-178. 13. Loots GG, Ovcharenko I: rVISTA 2.0: evolutionary analysis of transcription factor binding ... previously shown that there is position-specific variation in evolutionary rates within functional transcription factor binding sites [19] and that positions in a motif wit...

Ngày tải lên: 14/08/2014, 14:21

... dotted line). Thus, an increase in the number of binding sites or in the affinity of a binding site results in an increase of the Hill coefficient. This effect becomes stronger if the affinity of ... third binding site is uninfluenced, i.e. γ = 1.5, δ = 1 (dotted line in Fig 2A). The plot shows that a small increase in the affinity of the second binding site results in...

Ngày tải lên: 13/08/2014, 23:20

... and contain many short transcription factor binding sites [7]. Combinatorial regulation is certainly more likely to evolve in species in which binding sites are short and fuzzy, precisely because ... specificity of each specific binding sequence. In such a scenario, binding- site fuzziness is a consequence of the presence of multiple binding sites. Second, binding sites m...

Ngày tải lên: 14/08/2014, 15:20

... immediate intense activity that may initiate mecha- nisms that eventually lead to hypomyelination, or the period of inactivity that followed spinal cord injury called spinal shock. Either way hypomyelination ... pathophysiology of SCI in humans which may be additionally complicated by nerve root injury. While pathophysiology of SCI in humans has been subdi- vided into several different...

Ngày tải lên: 10/08/2014, 10:20

... which are found in all types of inflam- matory disease are involved in the changes in ion trans- port. In respiratory tract, gut and kidneys pro-inflammatory cytokines are involved in down regulation ... and hypokalemia in diarrhoeal diseases, electrolyte abnormalites in pyelonephritis of early infancy, septicemia induced pulmonary edema, and in hypersecretion and edema indu...

Ngày tải lên: 11/08/2014, 08:21

... Lapointe N, Routy JP, Sekaly RP, Conway B, Bernard NF: Longitudinal assessment of changes in HIV-specific effector activity in HIV-infected patients starting highly active antiretroviral therapy ... results on within-subject changes in HIV-spe- cific immunity induced in HIV infected patients (n = 10) in the chronic phase of infection who underwent therapy intensification and vac...

Ngày tải lên: 11/08/2014, 10:23

... smoking cessation on smoke -in duced changes in cytokine and chemo kine levels in BALF. Levels of the pro- inflammatory cytokine IL-12 (A), the regulatory cytokine IL-10 (B) and the growth factor ... smoking cessation on airway remodeling and pulmonary inflammation. The severity of airway remo- deling and inflammation was studied by determining alveolar enlargement, heart hypertrophy...

Ngày tải lên: 12/08/2014, 11:22

... However, in the Larsen scoring system, as in the SvdH scoring system, the feet do not have the same number o f joints as the hands, thus giving a c eiling effect with reduced possibility of finding ... AJ, Reid DM: Predicting erosive disease in rheumatoid arthritis. A longitudinal study of changes in bone density using digital X-ray radiogrammetry: a pilot study. Rheumatology (Oxfor...

Ngày tải lên: 12/08/2014, 15:22

... online http://ccforum.com/content/7/4/R67 Key messages • Changes in Sp O 2 do not reliably predict equivalent changes in Sa O 2 in the critically ill • Anaemia and acidosis have only a minor influence ... online http://ccforum.com/content/7/4/R67 Research Do changes in pulse oximeter oxygen saturation predict equivalent changes in arterial oxygen saturation? Gavin D Perkins...

Ngày tải lên: 12/08/2014, 19:22