Báo cáo y học: "eening the human exome: a comparison of whole genome and whole transcriptome sequencing" pot

... directly evaluate the sensitivity and specificity of RNA-Seq in identifying coding variants, and to evaluate how key parameters such as the degree of coverage and the expression levels of genes ... that at only one lane of RNA-Seq data, the specific-ity was 0.5 for SNVs with a read depth of 3, which was farbetter than the value of 0.28 found when using all eightlanes of data. Again, the ... specificity increased as the readdepth increased, but in this lower coverage dataset the specificity reached a plateau of between 0.6 and 0.75 atgreater than 10 reads, far earlier than the 50 reads...

Báo cáo y học: "An international sepsis survey: a study of doctors'''' knowledge and perception about sepsis" potx

... leukopenia by 20%, hypother-mia by 14%, and tachypnoea by 9% of physicians.Ability to diagnose sepsis and communicate about sepsisFour in five physicians (911 of 1058) agreed (strongly orsomewhat) ... generalawareness of the importance and impact of sepsis among the physicians interviewed. A vast majority of physicians considersepsis a leading cause of mortality. Moreover, the physiciansagree that sepsis ... (420 of 1058) had the impression that the inci-dence rate of sepsis has increased 'steadily' to 'dramatically'over the past 5 years, whereas 48% said that it remains stable.Two-thirds...

Báo cáo y học: "Cough quality in children: a comparison of subjective vs. bronchoscopic findings" doc

... Justin_Gaffney@health.qld.gov.au; Matthew Michael Eastburn - matt.eastburn@uq.edu.au; Joan Faoagali - Joan_Faoagali@health.qld.gov.au; Nancy C Cox - Nancy_Cox@health.qld.gov.au; Ian Brent Masters - Brent_masters@health.qld.gov.au* ... that the description of a cough as wet or drycough as determined by clinicians and parents has goodclinical validity as it has good agreement with, and relatesto, quantification of airway ... respectively and both helpeddraft the manuscript. IBM helped in formulation of over-all study design, data acquisition and drafting of the man-uscript. All authors read and approved the manuscript.Additional...

Báo cáo y học: "Cell death in sepsis: a matter of how, when, and where" potx

... cells and, alternatively, the capacity of apoptotic cells to induceanergy and a shift to a Th2-cell response. Furthermore,apoptosis of gastrointestinal epithelial cells may compromise the integrity ... survivalbut rather lead to alternative pathways of cell death. Indeed,apoptosis may even be protective, by obviating the potential of injured cells to necrosis and further propagating the inflammatory ... oxidative stress, and disturbance of calciumhomeostasis. Consequently, there are many potentialapproaches to pharmacologically modulate necrosis, includ-ing inhibition of the formation of reactive...

Báo cáo y học: "Vestibulo-ocular monitoring as a predictor of outcome after severe traumatic brain injury" pot

... was possible. The term galvanic labyrinth polarization (GaLa) was originallyintroduced after the discovery of animal electricity by Galvani[5] and is still employed, despite the fact that the ... administration of sedative ther-apy (see Table 2, demonstrating that sedative therapy wasapplied to all patients, regardless of whether they showed anOMR). In contrast, muscle relaxants can mask the ... their limitations and cannot always beemployed during the acute post-traumatic phase. Here electroencephalogram (EEG) could play an important role. But anal-gesic and sedative therapy is the...

Báo cáo y học: "Evaluating dosage compensation as a cause of duplicate gene retention in Paramecium tetraurelia" pot

... duplications, the average half-life of a genecopy is of the order of a few million years, with only a smallfraction of duplicates surviving beyond a few tens of millions of years (TH and DAL, ... 8:213MinireviewEvaluating dosage compensation as a cause of duplicate generetention in Paramecium tetraureliaTimothy Hughes*, Diana Ekman†, Himanshu Ardawatia*‡, Arne Elofsson† and David A Liberles‡Addresses: ... examination of a variety of genomes, tandem and segmental gene duplications are known to occur at very highrates (on average 0.01 per gene per million years), similar inmagnitude to the rate of mutation...

Báo cáo khoa học: "Vacuum-assisted breast biopsy: A comparison of 11-gauge and 8-gauge needles in benign breast disease" pptx

... pain scale from 0 (nopain) to 10 (unbearable pain) was used for this.Statistical analysisData was collected using Microsoft Access, and the statis-tical analysis was carried out using STATISTICA®. ... and 57 (76%) patients after 11-gaugebiopsy. The mean persistence of the haematomas in the 8-gauge group was 13 (2–43) days and 10 (2–56 days) in the 11-gauge group.ScarsNoticeable external ... contributionsMH and PS were the surgeons who performed all biopsies.MH and SO designed the current study and collected the data. MH and KF performed all data analyses. GH, BK,DW and UK–S edited the manuscript....

Báo cáo y học: " Early The glucocorticoid RU24858 does not distinguish between transrepression and transactivation in primary human eosinophils" pot

... mirkka.janka@uta.fi; Eeva Moilanen - eeva.moilanen@uta.fi; Hannele Hasala - hannele.hasala@uta.fi; Xianzhi Zhang - Xianzhi.Zhang@uta.fi; Ian Adcock - ian.adcock@imperial.ac.uk; Hannu Kankaanranta* - hannu.kankaanranta@uta.fi* ... data onwhether transactivation and/ or transrepression eventsplay a role in the regulation of apoptosis in human eosi-nophils.Based on the hypothesis that the predominant anti-inflammatory ... col-laboration in laboratory and in apoptosis studies. XZ and IA gave assistance in the design and drafting of the manu-script. HK conceived the study, and participated in itsdesign and coordination...

Báo cáo y học: "Spontaneous Hemoperitoneum Caused By a Diverticulum of the Sigmoid Colon"

... muscle layers. The vasa recta, which supply the mucosa and submucosa of the colon, penetrate the circular muscle. The weakness of the vascular portals in the circular muscle possibly causes ... recovery was une-ventful, and the patient was discharged on postoper-ative day 4. Fig.1 Fluid collection and left ovary cyst was noted on computed tomography. The size of ovary cyst was 2.0 ... copy owing to incomplete bowel preparation. The bleeding was controlled by #3-0 Vycryl intracorporeal suture, and the invagination of the diverticulum was performed laparoscopically. The...

Báo cáo Y học: Expanding the scorpion toxin a-KTX 15 family with AmmTX3 from Androctonus mauretanicus pptx

... [7]. Synthetic kaliotoxin(sKTX), P05 and BmTX3 (sBmTX3) were chemicallysynthesized as previously described [8–10]. IbTX and ChTXwere from Bachem Laboratory. Apamin, BSA and a- cyano-4-hydroxycinnamic ... scorpionsobtained by manual stimulation was generously providedby the Pasteur Institute at Casablanca, Morocco. Aa1 wasobtained from Androctonus australis venom bought fromLatoxan as previously described ... min, at a ﬂow rate of 1 mLÆmin)1; AUFS at 230 nm ¼ 1 (a) and at 280 nm (b)3. Inset: electrospray mass spectrum of AmmTX3. (C)Amino acid sequence of AmmTX3. The reduced and S-alkylatedAmmTX3...

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