Báo cáo y học: " Evidence for natural antisense transcript-mediated inhibition of microRNA function" ppsx
Báo cáo y học: " Evidence for natural antisense transcript-mediated inhibition of microRNA function" ppsx
... groups of regulatory RNAs in the computation of BACE1 gene expression. Moreover, bioinformatics analyses revealed a theoretical basis for many other potential interactions between natural antisense ... and BACE1-AS for binding toBACE1 mRNA. This novel masking function for the anti-sense RNA may apply to many other natural antisense transcripts.The effect of miR-485-5p on BACE1 may demonstrate ... variety of stressresponses [42,43]. A synergy between these two classes of ncRNAs as we have hypothesized here is an intriguingpossibility that would significantly increase the regula-tory power...
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Báo cáo Y học: Evidence for general stabilization of mRNAs in response to UV light pdf
... lM) as indicated. Cytoplasmic lysates were assayed for GFP-MKK62Eprotein by Western blot,and for activation of the p38 MAP kinase/MK2 pathway by in vitro kinase assays with recombinant HSP27 ... University of Medicine and Dentistry of New Jersey, Piscataway, NJ, USA. Mouse monoclonalantibodies 19F12 against HuR and 9H10 against hnRNPA1 were kindly donated by H. Furneaux, University of Conneticut ... USA, andG. Dreyfuss, University of Pennsylvania School of Medicine, Philadelphia, PA, USA, respectively.Transfections and reporter assays for mRNA stabilityTransient transfections by the calcium...
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Báo cáo y học: "Evidence for early disease-modifying drugs in rheumatoid arthritis" pps
... withcombination therapy at 2 years. Subsequent analysesfound that delaying DMARD therapy by only a few monthsdecreased the ability of the monotherapy to induce remis-sion [20]. The benefits of combination ... a 9-month RCT of hydrox-ychloroquine versus placebo in early RA. Three years afterthe study ended, early DMARD therapy still resulted inless pain and disability.The report by Verstappen and ... strong support for early DMARD therapy. Neverthe-less, the benefits of early DMARDs became less obviouswith time. By 5 years patients receiving early DMARDshad similar disease activity and comparable...
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Báo cáo y học: "Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis" pdf
... putative patho-genic pathways identified, suggesting that inhibition of neu-trophil activity may provide a useful means of limiting keyaspects of the pathology of polyarticular JRA. Genes down-regulated ... bottom of the tube. Red cells wereremoved from the granulocytes by hypotonic cell lysis as rec-ommended by the manufacturer, and granulocytes wereplaced immediately in Trizol reagent for RNA ... supportthe hypothesis that the defect may be primary. In earlier stud-ies of JRA using whole blood buffy coats, we demonstratedboth by discriminant function analysis and connectivity analy-ses...
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Báo cáo y học: " Evidence for genetic association of RORB with bipolar disorder" pptx
... 2Department of Biology, Indiana University, Bloomington, IN, USA, 3Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA, 4Laboratory of Neurophenomics, Department of Psychiatry, ... Fur-ther evidence for family-genetic risk factors in attention def-icit hyperactivity disorder. Patterns of comorbidity inprobands and relatives in psychiatrically and pediatricallyreferred ... represent susceptibility variants for bipolar disorder, it is possible they do so by altering theexpression of one or both of the RORB isoforms. One of thehaplotype blocks exhibiting a positive...
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Báo cáo y học: " Prevention for those who have freedom of choice – or among the choice-disabled: confronting equity in" pps
... mainimpact of an apparently protective intervention, like malecircumcision, will be for HIV-negative young men who arenot victims of forced sex. If two in every ten are alreadyHIV-positive ... andless likely to be willing to go for testing. And children whohad endured sexual abuse or who believed they were HIVpositive were more likely to say they would spread HIVintentionally (20% among ... national survey of South African schools producedworrying findings about the culture associated with sexualviolence. Children who suffered forced sex were verymuch more likely to believe they were...
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Báo cáo y học: " Evidence-based practice implementation: The impact of public versus private sector organization type on organizational support, provider attitudes, and adoption of evidence-based practice" doc
... use of EBPs, and organizational characteristics related to EBPs).Additionally, several of the study's primary hypothesesinvolve objectively measured criterion such as type of agency (i.e., ... Presidential Task Force on Evidence- Based Practice: Evidence- Based Practice in Psychology. Am Psychol 2006, 61:271-285.64. Institute of Medicine: Crossing the quality chasm: A new health system for the ... model of the effect of agency type on attitudes toward EBP medi-ated by organizational support for EBP, and full media-tion of the effect of organizational support for EBP on EBPuse mediated by...
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Báo cáo y học: " Protocol for a randomised controlled trial of risk screening and early intervention comparing childand family-focused cognitive-behavioural therapy for PTSD in children following accidental injury" pot
... in the childFamily must live within 200 km’s or be willing to travel for weekly therapy sessions Child currently under the care of Department of Child SafetyInjury due to physical or sexual ... quality of life. Further, the design of the study will allow for anexamination of improvements and maintenance of gains (for the active treatments) over a 12-month follow-upperiod.Study HypothesesIt ... anxi-ety, measured by the State Trait Anxiety Inventory[STAI; [40]].Kenardy et al. BMC Psychiatry 2010, 10:92http://www.biomedcentral.com/1471-244X/10/92Page 6 of 9Approximate ly 25% of children...
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Báo cáo y học: " Protocol for a randomised controlled trial of risk screening and early intervention comparing childand family-focused cognitive-behavioural therapy for PTSD in children following accidental injury" pptx
... details1Centre of National Research on Disability and Rehabilitation Medicine,School of Medicine, University of Queensland, Herston QLD 4029, Australia.2School of Psychology, University of Queensland, ... prediction of PTSD symptomatology in children andadolescents. American Journal of Psychiatry 2006, 163:644-651.3. Scheeringa MS, Zeanah CH, Myers L, Putnam FW: New findings onalternative criteria for ... in preschool children. Journal of the AmericanAcademy of Child & Adolescent Psychiatry 2003, 42:561-570.Pre-publication historyThe pre-publication history for this paper can be accessed...
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Báo cáo y học: "Intramuscular Olanzapine – a UK case series of early cases" ppsx
... majority of patientsthat require rapid tranquilisation have some form of seri-ous psychosis and may also have physical problems suchas biochemical disturbances and dehydration [3,4] For many years ... http://www.annals-general-psychiatry.com/content/6/1/11Page 5 of 5(page number not for citation purposes)Competing interestsChris Bushe is an employee of Eli-Lilly UK.Dr M Taylor has received hospitality from ... 2003,119:113-123.2. Jones B, Taylor C, Meehan K: The efficacy of a rapid acting for- mulation of intramuscular olanzapine for positive symp-toms. J Clin Psychiatry 2001, 62(Suppl 2):22-24.3....
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