Báo cáo y học: "Nucleosome rotational setting is associated with transcriptional regulation in promoters of tissue-specific human genes" pot

... univer- sally present in eukaryotes, albeit involving different dinucleotides. The same periodic RR/YY dinucleotide frequency is seen in human and mouse promoters, but interestingly the medaka fish Oryzias ... which is probably a determinant of the energeti- cally more favorable smooth versus kinked bending of the DNA [10]; and an arginine side-chain is located in the minor...

Ngày tải lên: 09/08/2014, 20:22

... negativity in the Farr assay. We did not find aPL at baseline in our patients with RA. Anti- cardiolipin autoantibodies were induced in 3.5% (2 of 57) and 1.8% (1 of 55) of our patients with RA, ... (diluted 1:100 in PBS) were distributed into individual wells. The microtiter plates were coated with highly purified synthetic cyclic pep- tides containing modified arginine r...

Ngày tải lên: 09/08/2014, 07:20

... f inflammatory cytokines. The result is a production of pro-inflammatory cytokines that are b alanced by an array of anti-inflammatory cyto- kines. The coagulation pathway is also activated by ... cell shrinkage (pyknosis) and nuclear fragmentation (karyorrhexis) [52]. The regula- tion of apoptosis in sepsis is complex, as the infecting pathogen may inhibit or induce apoptosis,...

Ngày tải lên: 11/08/2014, 08:22

... transfere findings of the association of the COMTval158met polymorphism from an experimental extinction study [3] obtained using healthy subjects to a clinical setting. Furthermore, our finding of (tendentially) ... COMTval158met polymorphism on extinction into a clinical setting by investigating the effi- cacy of CBT (in particular exposure-based treatment modules) in a sample...

Ngày tải lên: 11/08/2014, 16:22

... FMD is significantl y associated with ventilatory efficiency. This result may be interpreted as a potential clinical link between smoking and early pulmonary vasculopathy due to smoking. Introduction Endothelial ... addition, ventilatory efficiency and gas exchange may be impacted by early air- way disease as well. The potential link between smoking, early airway disease and pulmo nar...

Ngày tải lên: 12/08/2014, 13:22

... adiponectin was not associated with exhaled lev- els of 8-isoprostanes, which may be indicative that other adipokine-independent pathways exist in increasing BMI- related airway oxidation. This study ... associated with acute lung injury in the presence of hyperoxia [45]. In contrast, adiponectin is inversely associated with biomar- kers of inflammation and with BM...

Ngày tải lên: 12/08/2014, 15:20

... presence of associated pulmonary hypertension. Ventilation-perfusion scintigra- phy can be useful in the diagnosis and in distinguishing UAPA from SJMS, but this study is limited in its ability to ... to the nonspecific clinical characteristics of the disease, a delay in diagnosis of 30 years after the onset of symp- toms can be observed [2]. Typical chest radiographic fin...

Ngày tải lên: 10/08/2014, 23:22

... thrombopoietin and erythropoie- tin might explain thrombocytosis in children with iron- deficiency anemia [8]. In our case, we observed a marked increase in the level of erythropoietin which declined ... with erythrocyte transfusion, and normalization of serum iron and decline of erythropoietin. Finally, following small bowel biopsy, despite the absence of typical clinical s...

Ngày tải lên: 11/08/2014, 23:21

... reveals association of increasing disease severity with emergence of novel hemagglutinin mutations. Cell Cycle 2010, 9:958-970. 11. Bao Y, Bolotov P, Dernovoy D, Kiryutin B, Zaslavsky L, Tatusova T, ... The muta- tion is not in close vicinity (within 5 Angstroem) of PB1 or PA in any currently known structure. 8 of 123 strains with PB2-K340N and HA sequence information in...

Ngày tải lên: 12/08/2014, 02:20

... shock induced a quick and transient phosphorylation of Sty1p that became dephosphorylated within 60–90 min. This is likely due to the activity of threonine-phosphatases Ptc1p and Ptc3p and tyrosine-phosphatase ... DISCUSSION The main aim of this study was to analyse the cold shock response in S. pombe,ayeastthatdisplaysacascadeof stress activated protein kinases homologous to the SA...

Ngày tải lên: 08/03/2014, 09:20