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Báo cáo y học: "Computational challenges in the analysis of ancient DNA" ppsx

Báo cáo y học:

Báo cáo y học: "Computational challenges in the analysis of ancient DNA" ppsx

... explained in the following way. The chance of finding a seed-match and of producing a local alignment of significant similarity rises with the length of the frag-ment. Longer fragments, then, ... be taken to minimize the effect of these factors. In our analysis we excluded ancient DNAmisincorporations, which usually lead to transitions, bysimply calculating only the number of transversions ... appropriate filtering.BackgroundMost of our understanding of how extinct species arerelated to living species has come from morphological analysis of fossil remains. Recovery and analysis of DNAextracted...
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Báo cáo y học: "Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities"

... purposes) of portacaval shunting, thereby decreasing first passmetabolism; decrease in quantities and affinity of plasmaproteins, thereby increasing free-drug levels; increase in volume of distribution ... and lamotrigine. The triad of hypersensi-tivity includes fever, rash and internal organ involvementwith onset of symptoms within 1 to 8 weeks of exposure. The frequency of the syndrome is estimated ... [57].Recognizing early symptoms of hepatic toxicity and dis-continuing treatment are important in optimizing recov-ery. Early symptoms of hepatic toxicity include apathy,malaise, fever, diminished...
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Báo cáo Y học: Expression pattern in the antennae of a newly isolated lepidopteran Gq protein a subunit cDNA potx

Báo cáo Y học: Expression pattern in the antennae of a newly isolated lepidopteran Gq protein a subunit cDNA potx

... be the start of the proteincoding domain. Sequence analysis of the 3¢ end cDNArevealed that there is a polyadenylation signal upstream of the poly(A). Analysis of the primary structure of M. ... 2002Recently, the a subunit of a G protein of the Gq familyhas been immunolocalized in olfactory sensilla preparations of the silkmoth Antherea pernyi [23]. Using immunocytol-ogy, the authors ... samecharacteristics, the molecular cloning of the correspondingcDNA to get the total amino-acid sequence of the protein,and the expression pattern of the corresponding mRNAas a first step to clarify the role of...
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Báo cáo y học: "Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes" ppt

... fibroblast lines. YM participated in the molecular genetic studies and analysis. EK procured the sam-ples and helped in the analysis of data. GW participated in the design of the study, analysis of data, ... earlybacterial infection in the joint. Somatic mutations in mitochondrial peptides displayed by MHCs may be recognizedas non-self, furthering the destructive immune infiltration of the RA joint. ... derived from the amino terminus of mtND1 [14]. These findings provide evi-dence that antigenic peptides of human mtND1 may be dis-played and recognized by the immune system.To test the hypothesis...
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Báo cáo y học: "Psychosocial aspects in the management of arthritis pain" pot

... of leisure in maintaining or restoring psychological well-being in the presence of arthritis pain warrants furtherstudy.Psychosocial approaches to managingarthritis painSearch strategy The ... [16]compared the psychosocial functioning and coping of mothers with chronic pain (including mothers with arthritis) tomothers without pain, with regard to their ratings of parentingefficacy. There ... Acomparison of conventional pain coping skills training andpain coping skills training with a maintenance training com-ponent: A daily diary analysis of short- and long-term treat-ment effects. J Pain...
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Báo cáo y học:

Báo cáo y học: " Immune mechanisms in the pathogenesis of idiopathic inflammatory myopathies" doc

... concerning the role of T lymphocytes, B lymphocytes, dendritic cells, andother antigen-presenting cells (APCs) in the pathophysiology of IIMs.T lymphocytesT lymphocyte functionT lymphocytes ... demonstrated the presence of differentiated B lymphocytes in the form of CD138+plasmacells predominantly in the endomysium of muscle tissue of patients with polymyositis and inclusion-body myositis ... plasmacytoid DCs wasfound in comparison with the amount of myeloid DCs [48]. The importance of the plasmacytoid DCs in activating the typeI interferon system in dermatomyositis was suggested by...
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Báo cáo y học: "Current approaches in the treatment of arthritic pain" pps

... beconfined to the periphery. The finding of increased areas of punctate hyperalgesia in patients with RA after topicalapplication of capsaicin is in accord with increasedexcitability of spinal ... also likely to influence activity. The multiplicity of mediators involved provides an opportunity for therapeuticintervention, and many of the commonly used therapeuticstrategies including acupuncture, ... concept of a fixed immutable pain system thatfaithfully transmits information from a site of injury to paincentres within the brain. Although this is largely true afteracute injury, it is...
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Báo cáo y học: "Recent developments in the immunobiology of rheumatoid arthritis" potx

... anti-IL-15 therapy in RA patients [29].T helper 17 cellsThere is increasing evidence that IL-17 plays a role in the immunopathology of RA. This proinflammatory cytokine isproduced by T helper ... anti-CD20 antibody[2], and the increased interest in the role of autoantibodies in RA. In addition to producing antibodies, proinflammatorycytokines and chemokines, B cells efficiently act as antigen-presenting ... cells, the products they produce, including cytokines andautoantibodies, and the genetic factors potentially involved in their regulation and function.T cells In contrast to the clearly defined...
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Báo cáo y học: "Clinical significance in the number of involved lymph nodes in patients that underwent surgery for pathological stage III-N2 non-small cell lung cancer" pot

... Surgery appears to be preferable as a one arm of multimodality therapy in p-stage III/N2 patients withsingle or 2 involved lymp h nodes. The optimal incorporation of surgery into the multimodality ... conceived of the study, and drafted the manuscript. MT participated in the study and performed the statistical analysis. SO, YS, YN, HS, HU, and FTparticipated in the study and coordination. ... imaging) of the brain was routinely employed forasse ssment of distant meta stasis. Bronchoscopy was rou-tinely performed to obtain a pathological diagnosis bytransbronchial lung biopsy, and...
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Báo cáo y học:

Báo cáo y học: "Dendritic cells: In the forefront of immunopathogenesis and vaccine development – A review." doc

... thymus reactive T lymphocytes, they will be deletedindicating that DCs play a critical role in this process.Moreover, in the cortical area of the thymus, althoughmacrophages phagocytize dying ... delivery system also offers an interestingroute to approach DC subsets in order to enhance immu-nity against cancer or pathogens. Accordingly, the immune system of the skin harbors two very potent ... capability, they couldacquire tumor antigen. In the past few years the role of DCs in cancer has beensuggested. There is evidence that DCs can induce immu-nity to tumors if they are administrated...
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