Báo cáo y học: "GWASs and the age of human as the model organism for autoimmune genetic research" doc
Báo cáo y học: "GWASs and the age of human as the model organism for autoimmune genetic research" doc
... will identify more. Is it time to make human the model organism for autoimmune research?© 2010 BioMed Central LtdGWASs and the age of human as the model organism for autoimmune genetic researchRobert ... article as: Plenge R: GWASs and the age of human as the model organism for autoimmune genetic research. Genome Biology 2010, 11:212.Plenge Genome Biology 2010, 11:212 http://genomebiology.com/2010/11/5/212Page ... increase the disease risk by only 10 to 20% (corresponding to an odds ratio (OR) of 1.10 to 1.20 per copy of the risk allele). (e OR is a measure of the strength of association; it refers to the...
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Báo cáo y học: " Derivation and preliminary validation of an administrative claims-based algorithm for the effectiveness of medications for rheumatoid arthritis"
... activity scores (DAS), as assessed by physicians using the DAS28 [23] and the Clinical Disease Activity Index (CDAI) [24], as well as a bio-repository with banked DNA, serum, and plasma. VARA data ... were used only to capture the DAS28, the CDAI and other clinical characteristics measured at the baseline and outcome VARA visits; all other data used for the analysis were from the administrative ... comorbidities, or the physician/patient was satisfied with the level of disease activity even though the patient did not meet the DAS28 criteria for low disease activity or improvement. For the 23 treatment...
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Báo cáo y học: " Dimensional and hierarchical models of depression using the Beck Depression Inventory-II in an Arab college student sample" pot
... per year of study for the fouryears of study. They s elf-completed the questionnairesanonymously. First, the objectives of the study wereexplained. The students were duly informed that theywere ... hierarchical model represented by the bifactor approach is emerging as the best way to account for the clinical heterogeneity of depression, and the adequacy of the psychometriccharacteristics of the ... calculated: the total score is the average of all 25items; the anxiety score is the average of the 10 anxietyitems; while the depression score is the average of the 15 depression items. The internal...
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Báo cáo y học: "Structural and functional characterization of human apolipoprotein E 72-166 peptides in both aqueous and lipid environments" pot
... aminoacids and there are three isoforms, apoE2, apoE3, and apoE4, encoded by the ε2, ε3, and ε4 genes, respectively.These isoforms differ from each other only at residues112 and 158 i.e. Cys112 and Arg158 ... the VLDL band was shifted with the binding of apoEproteins.LDLR Binding Assay The detailed procedures for the LDLR binding assayhave been described previously [22,37,38]. Briefly, human ... properties of the three apoE-(72-166) isoforms. In the presence of lipid, the degree of apoE-(72-166) disso-ciation and extended conformation was significantlyelevated. The functional assays conclude...
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Báo cáo y học: "Enhancing versus Suppressive Effects of Stress on Immune Function: Implications for Immunoprotection versus Immunopathology" doc
... importantrepresentation of the state of distribution of leukocytesin the body and of the state of activation of the immunesystem. The ability of acute stress to induce changes inleukocyte distribution ... blood leukocyte numbers are characterized bya significant decrease in the numbers and percentages of lymphocytes and monocytes and by an increase in the numbers and percentages of neutrophils.2,35Flow ... earlyincreases in lymphocyte numbers, whereas the moredelayed rise in plasma cortisol preceded the late decreasein lymphocyte numbers.41Importantly, changes in NK cellactivity and antibody-dependent...
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Tài liệu Báo cáo Y học: Antibacterial and antifungal properties of a-helical, cationic peptides in the venom of scorpions from southern Africa pptx
... program(http://www.expasy.ch/cgi-bin/peptide-mass.pl).Chemical synthesis of parabutoporin and opistoporin The peptides were prepared by solid-phase synthesis byAnsynth Service B.V. (the Netherlands) using the ... Neurosporacrassa, the phytopathogenic fungi Botrytis cinerea and Fusarium culmorum, and the yeast Saccharomyces cerevisiaewere used as test organisms in the assay. All peptides inhibit50% of growth of ... The multiply-charged ion spectrum was transformed to molecular massby the Maxent software (Micromass, UK). The masses of the peptides resulting from the tryptic digestion weredetermined by...
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Báo cáo Y học: Structural and biochemical characterization of calhepatin, an S100-like calcium-binding protein from the liver of lungfish (Lepidosiren paradoxa) docx
... structure of lungfish calhepatin predicted using the Swiss- Model automated modelling package basedon the crystal and/ or NMR structures of othermembers of the family. The molecule isdepicted in strand ... equilibrium and that the dissociationconstant is in the micromolar range for the apoprotein and in the submicromolar range for the holoprotein, as reported for other S100 family members [7]. Tarabykinaet ... S100family, the S100 A12 [10]. Hofmann et al. [11] proved thatS100 A12, and possibly other members of the S100 family,mediates the activation of a novel proinflammatory axis bybinding to RAGE (receptor...
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Báo cáo Y học: Expression and purification of the recombinant subunits of toluene/ o-xylene monooxygenase and reconstitution of the active complex potx
... to modulate the activity of the hydroxylase component of the complex, as itTable 1. Single-turnover assays catalyzed by the components of the toluene/o-xylene monooxygenase complex. The experiments ... parallel the effect of the absence of other homologous regulatory subunits of oxygenase complexes, like T4MOD [33] and componentB of methane monooxygenases [38,39]. In these cases the absence of the ... 1.72Fig. 5. The effect of different ratios of Tomo C (A), Tomo D (B) and Tomo F (C) components with respect to the hydroxylase on the rate of toluene/o-xylene monooxygenase. Activity was measured as describedin...
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Báo cáo Y học: Structural and serological relatedness of the O-antigens of Proteus penneri 1 and 4 from a novel Proteus serogroup O72 pptx
... As judged by the ratio of the integral intensities of the signals in the major and minor series, the average degree of glycosylation with GlcIIis 75%.Comparison of the 13C NMR spectra of ... and 2.06.Therefore, the polysaccharide has a tetrasacchariderepeating unit containing one residue each of D-Glc and D-Gal and twoD-residues of GalNAc. The 1H- and 13C NMR spectra of the ... Shashkov2 and Yuriy A. Knirel21Department of General Microbiology, Institute of Microbiology and Immunology, University of èodzÂ, Poland;2N. D. ZelinskyInstitute of Organic Chemistry, Russian...
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Báo cáo Y học: Synthesis and turn-over of the replicative Cdc6 protein during the HeLa cell cycle potx
... across the yeastcell cycle. They rapidly decrease w ith the entry of yeast cellsinto S phase and increase again during t he following G1phase with the synthesis of new Cdc6p.In contrast, the ... with[35S]methionine for 2 h at the beginning (0–2 h afterthymidine-block) and in the middle of S phase (4–6 h), as well as at the e nd of mitosis and during the early G1 phase(12–14 h) of the next cycle (Fig. ... of the pulse-labelappeared in cytoplasmic hCdc6p, and the other half inchromatin-bound hCdc6p. The phosphorylated upper-bandform of labeled cytoplasmic hCdc6p r apidly disappearedduring the...
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