Báo cáo y học: "GWASs and the age of human as the model organism for autoimmune genetic research" doc

... will identify more. Is it time to make human the model organism for autoimmune research? © 2010 BioMed Central Ltd GWASs and the age of human as the model organism for autoimmune genetic research Robert ... article as: Plenge R: GWASs and the age of human as the model organism for autoimmune genetic research. Genome Biology 2010, 1...

Ngày tải lên: 09/08/2014, 20:21

... activity scores (DAS), as assessed by physicians using the DAS28 [23] and the Clinical Disease Activity Index (CDAI) [24], as well as a bio-repository with banked DNA, serum, and plasma. VARA data ... were used only to capture the DAS28, the CDAI and other clinical characteristics measured at the baseline and outcome VARA visits; all other data used for the ana...

Ngày tải lên: 25/10/2012, 10:45

... per year of study for the four years of study. They s elf-completed the questionnaires anonymously. First, the objectives of the study were explained. The students were duly informed that they were ... hierarchical model represented by the bifactor approach is emerging as the best way to account for the clinical heterogeneity of depression, and the adequacy...

Ngày tải lên: 11/08/2014, 16:22

... amino acids and there are three isoforms, apoE2, apoE3, and apoE4, encoded by the ε2, ε3, and ε4 genes, respectively. These isoforms differ from each other only at residues 112 and 158 i.e. Cys112 and Arg158 ... the VLDL band was shifted with the binding of apoE proteins. LDLR Binding Assay The detailed procedures for the LDLR binding assay have been described previous...

Ngày tải lên: 10/08/2014, 05:21

... important representation of the state of distribution of leukocytes in the body and of the state of activation of the immune system. The ability of acute stress to induce changes in leukocyte distribution ... blood leukocyte numbers are characterized by a significant decrease in the numbers and percentages of lymphocytes and monocytes and by an increase in...

Ngày tải lên: 08/08/2014, 21:20

... program (http://www.expasy.ch/cgi-bin/peptide-mass.pl). Chemical synthesis of parabutoporin and opistoporin The peptides were prepared by solid-phase synthesis by Ansynth Service B.V. (the Netherlands) using the ... Neurospora crassa, the phytopathogenic fungi Botrytis cinerea and Fusarium culmorum, and the yeast Saccharomyces cerevisiae were used as test organisms in the...

Ngày tải lên: 21/02/2014, 15:20

... structure of lungfish calhepatin predicted using the Swiss- Model automated modelling package based on the crystal and/ or NMR structures of other members of the family. The molecule is depicted in strand ... equilibrium and that the dissociation constant is in the micromolar range for the apoprotein and in the submicromolar range for the holoprotein, as re...

Ngày tải lên: 08/03/2014, 22:20

... to modulate the activity of the hydroxylase component of the complex, as it Table 1. Single-turnover assays catalyzed by the components of the toluene/o-xylene monooxygenase complex. The experiments ... parallel the effect of the absence of other homologous regulatory subunits of oxygenase complexes, like T4MOD [33] and component B of methane monooxygenases [...

Ngày tải lên: 17/03/2014, 10:20

... As judged by the ratio of the integral intensities of the signals in the major and minor series, the average degree of glycosylation with Glc II is  75%. Comparison of the 13 C NMR spectra of ... and 2.06. Therefore, the polysaccharide has a tetrasaccharide repeating unit containing one residue each of D -Glc and D -Gal and two D -residues of GalNAc. Th...

Ngày tải lên: 17/03/2014, 17:20

... across the yeast cell cycle. They rapidly decrease w ith the entry of yeast cells into S phase and increase again during t he following G1 phase with the synthesis of new Cdc6p. In contrast, the ... with [ 35 S]methionine for 2 h at the beginning (0–2 h after thymidine-block) and in the middle of S phase (4–6 h), as well as at the e nd of mitosis and during...

Ngày tải lên: 17/03/2014, 23:20