Báo cáo y học: "Cancer genomics identifies determinants of tumor biology" ppt

... transcript fusion. ese types of alterations may explain certain aspects of tumor biology and may also be corroborated by cytogenetic phenomena. In this review, I will describe some tumor- specific altera- tions ... because α-KG is required by prolyl hydroxy- lases, enzymes that hydroxylate and promote the degra- dation of hypoxia-inducible factor 1α (HIF-1α), the intra- cellular l...

Ngày tải lên: 09/08/2014, 20:21

... of the boundaries of a well-functioning system’s health territory, a living en- tity can enter either further into the zone of chaos or a zone of entropy, each dramatically affecting the system. ... Complexity governs the myriad of interactions within a system. “Complexity…[is] a science of emer- gence” [4] allowing system’s ultimate mission, the creation of emergence. Compl...

Ngày tải lên: 26/10/2012, 10:04

... University of Miyazaki,5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. † Division of Microbiology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki,5200 Kihara, Kiyotake, ... composed of 22 singleton genes and 4 repeated Summary of the CGH and WGPScanning analyses of O157 and non-O157 EHEC strainsFigure 1 (see previous page) Summary of the...

Ngày tải lên: 14/08/2014, 07:22

... laterality, and the Levy-Nagylaki model of handedness and cerebral organisation. Neuropsychologia 1980, 18:99-102. 16. Beaumont JG, McCarthy R: Dichotic ear asymmetry and writing posture. Neuropsychologia ... injection of sodium amytal for the lateralisation of sebrebral speech dominance. J Neurosurg 1960, 17:266-282. 31. Weiner RD: The psychiatric use of electrically induced seizures...

Ngày tải lên: 08/08/2014, 20:23

... procollagen prolyl hydroxylases (P4HA1 and P4HA2), lysyl oxidase (LOX) and lysyl hydroxylases (procollagen lysyl hydroxylase and procollagen lysyl hydroxylase 2). Similar links between hypoxia and ... oxygen-dependent regu- lation of HIF-1α. This hydroxylation is catalyzed by a family of 2-oxoglutarate dependent dioxygenases called prolyl hydroxy- lase domains (PHDs) [7]. During the hydro...

Ngày tải lên: 09/08/2014, 01:22

... evolution of the duck-billed platypus karyotype with an X 1Y1 X 2Y2 X 3Y3 X 4Y4 X 5Y5 male sex chromosome constitution. Proc Natl Acad Sci USA 2004, 101:16257-16261. 23. Bick YAE: The meiotic chain of chromosomes ... Echidnas Edited by: Augee ML. Sydney: Royal Zoological Society of New South Wales; 1992:28-34. 28. Kirsch JA, Mayer GC: The platypus is not a rodent: DNA hybridization, am...

Ngày tải lên: 14/08/2014, 08:20

... identically they tend more frequently to be correct. Figure 4 shows that by restricting the analysis to only those exons that are predicted identically by two programs, exon prediction specificity jumps ... correct, regardless of the two programs chosen. Exon prediction specificity Ab initio prediction sensitivity by exon typeFigure 2 Ab initio prediction sensitivity by exon type. Individua...

Ngày tải lên: 14/08/2014, 08:20

... Ltd A report of the Keystone Symposium ‘Regulation of Eukaryotic Transcription: From Chromatin to mRNA’, Taos, USA, 21-26 April 2006. Transcription of protein-coding genes in eukaryotes involves a ... Real-time analysis of transcription in vivo John Lis (Cornell University, Ithaca, USA) presented a visual- ization of the dynamic interactions of transcription factors with the pol...

Ngày tải lên: 14/08/2014, 16:21

... such as Nudix hydrolases (which hydrolyze a variety of nucleoside diphosphate derivatives) and enzymes involved in amino acid breakdown. This is possibly because of higher levels of toxic inter- mediates ... analysis of 114 proteins previously identified as being enriched to the spindle pole in human cells. Forty of these gave statistically consistent phenotypes affecting the spindl...

Ngày tải lên: 14/08/2014, 21:20

... whether any of the non-coding RNAs found at or near promoters and TSSs have any biological function, or whether they simply represent byproducts of stalled polymerases or the degradation of longer ... part of a more general question: what is the complexity of polypeptides made in human cells, given the apparently high transcriptional complexity of RNAs made from a protein-coding l...

Ngày tải lên: 14/08/2014, 21:20