Báo cáo y học: "miRTRAP, a computational method for the systematic identification of miRNAs from high throughput sequencing data" pptx
Báo cáo y học: "miRTRAP, a computational method for the systematic identification of miRNAs from high throughput sequencing data" pptx
... apparent false negative rate of approxi-mately 5% and a false discovery rate of approximately19%.To systematically compare the miRTRAP and miRDeepmethods, we tested the new Ciona library data using ... computational analysis. WS and DH analyzed the data. WS, DH and ML wrote the manuscript. All authors read and approved the final manuscript.AcknowledgementsWe thank Benjamin Haley for sharing ... their miRNA partners in RNA silencing. Proc Natl Acad Sci USA 2008, 105:7964-7969.33. Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki...
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Báo cáo y học: "InSite: a computational method for identifying protein-protein interaction binding sites on a proteome-wide scale" pot
... 'observed interaction' variables for each of the assays, as follows. For the yeast two-hybrid datasets of [9,10], these variables are binary-valued. They take the value'true' ... sensors for the actual interaction variable Tij.I. Notethat an actual interaction variable may have several observa-tion variables if the pair appears in multiple assays. For thoseassays with ... interactionassays. For these gold standard pairs, we fixed the value of the 'actual interaction' variable accordingly. In all other proteinpairs, we leave the actual interaction variables as...
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Báo cáo y học: "FusionSeq: a modular framework for finding gene fusions by analyzing paired-end RNA-sequencing data" pdf
... twoends of a PE read, ge ne annotation sets, expressionvalues, and so on.Software and data availabilityFusionSeq is available for download at [34]. Data setsused in this study are available via ... helped analyze the data and drafted the manuscript.Additional materialAdditional file 1: Supplementary material, tables and figures .The results of different mapping tools and approaches, the description ... transcription factor genes in prostate cancer. Science 2005,310:644-648.24. Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara S,Watanabe H, Kurashina K, Hatanaka H, Bando...
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Báo cáo y học: "Hybrid dynamic/static method for large-scale simulation of metabolism" pptx
... metabolismKatsuyuki Yugi†, Yoichi Nakayama*†, Ayako Kinoshita and Masaru TomitaAddress: Institute for Advanced Biosciences, Keio University, Fujisawa, Kanagawa, 252–8520, Japan.Email: Katsuyuki Yugi ... Additionalfile 1].Evaluation of errors at steady stateTo compare the accuracy of the hybrid method with the conventional dynamic kinetic method analytically, wefirst employed a pathway model ... this method can drastically reduce the number of enzymekinetics assays needed to obtain the dynamic properties of the pathway. We have evaluated the accuracy of the hybrid method in comparison...
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Báo cáo y học: "Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences" ppsx
... provides a framework for perform-ing computational analyses, systematically repeating ana-lyses, capturing all details of performed analyses, andannotating analyses. Using Galaxy Pages, researcherscan ... When a user performs an analysis using Galaxy,it automatically generates metadata for each analysisstep. Galaxy’s metadata includes every piece of informa-tion necessary to track provenance and ... does not make repeating an analysiseasy. The Galaxy workflow system facilitates analysisrepeatability and, like Galaxy’s accessibility model, in a way that is usable even to users that have little...
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Báo cáo Y học: Kinetic and biochemical analyses on the reaction mechanism of a bacterial ATP-citrate lyase ppt
... biochemical analyses on the reaction mechanism of a bacterial ATP-citrate lyaseTadayoshi Kanao, Toshiaki Fukui, Haruyuki Atomi and Tadayuki ImanakaDepartment of Synthetic Chemistry and Biological ... play a vital role in providing acetyl-CoA andoxaloacetate in the cytosol as starting materials for a variety of biosynthetic pathways. Rat and human ACLs from various organs and tissues have ... the subunits was confirmed by SDS/PAGE analysis.Assay of enzyme activityACL activity was assayed by the coupled malate dehydrog-enase (MDH) method [17]. The reaction mixture contained10 mMMgCl2,10mMdithiothreitol...
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Báo cáo y học: "Deep transcranial magnetic stimulation for the treatment of auditory hallucinations: a preliminary open-label study" pptx
... department of Beer Ya’akov Mental Health Center andhead of the electroconvulsive therapy unit of the Beer Ya’akov Mental HealthCenter. PD is paid by by Beer Ya’akov Mental Health Center. YR ... Beer Ya’akov Mental HealthCenter. ZA works at the Department of Neurobiology of the WeizmannInstitute of Science and also serves as a research consultant for Brainsway. DPis head of the research ... magneticstimulation for the tre atment of auditory hallucinations: a preliminaryopen-label study. Annals of General Psychiatry 2011 10:3.Submit your next manuscript to BioMed Centraland take full advantage...
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Báo cáo y học: "TWEAK: a novel biomarker for lupus nephritis" pot
... sensitivity and specificity. In the previous issue of ArthritisResearch & Therapy, Schwartz and colleagues demonstrated the potential value of urinary TNF-like weak inducer of apoptosis(uTWEAK) as ... inadequate becausesubstantial renal tissue damage can occur before function isimpaired to a detectable extent [4]. Renal biopsy remains the gold standard for assessment of LN disease activity. ... degree of clinical disease activity. These dataare thought-provoking and provide the platform for future longer-term studies.In the previous issue of Arthritis Research & Therapy,Schwartz and...
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Báo cáo y học: " NeMeSys: a biological resource for narrowing the gap between sequence and function in the human pathogen Neisseria meningitid" pot
... chromosomal inversions (Additional data file 1).To achieve an annotation as accurate as possible, we anno-tated 8013's genome manually by taking advantage of all the functionalities of the ... reported the assembly of an archivedlibrary of 4,548 transposition mutants in strain 8013 and the design of a method for high- throughput characterization of transposon insertion sites based on ligation-mediated ... comparative genomics a complete biochemical pathway (for sulfur metabolism) that may potentially be important for nasopharyngeal colonization.Conclusions: By improving our capacity to understand...
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Báo cáo y học: "Are chest compressions safe for the patient reconstructed with sternal plates? Evaluating the safety of cardiopulmonary resuscitation using a human cadaveric model" docx
... 2 2 lateral, xyphoidCadaver 3 2 lateralCadaver 4 3 lateralCadaver 5 1 lateralFigure 3 Elevation and examination of deep sternal cortex andviscera.McKay et al. Journal of Cardiothoracic ... Evaluating the safety of cardiopulmonary resuscitation using a human cadaveric modelDouglas R McKay1*, Hosam F Fawzy2, Kathryn M McKay3, Romy Nitsch4, James L Mahoney5AbstractBackground: ... University, Kingston, Ontario, CanadaFull list of author information is available at the end of the articleMcKay et al. Journal of Cardiothoracic Surgery 2010, 5:64http://www.cardiothoracicsurgery.org/content/5/1/64©...
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