Báo cáo y học: "Advances in understanding genome maintenance" pps

... elimination of the virus but is also responsible for liver damage caused by the lytic activity of HBV- specific cytotoxic T lymphocytes (CTL) on HBV- infected hepatocytes and by production of inflammatory ... respectively. Interestingly, an increase in virological response over time after the discontinuation of thymosin could be observed (p=0.02) [40]. The doses of thymosin α...

Ngày tải lên: 02/11/2012, 11:17

... discovered in Central America [51]. The study of possible clinical ramifications of HBV genotypes is the subject of intense clinical research, with evidence accumulating that HBV genotyping influences ... generally defined clinically by a rise in serum HBV DNA levels during antiviral therapy. Although HBV DNA assays will eventually detect changes in viral load as a con...

Ngày tải lên: 03/11/2012, 09:41

Ngày tải lên: 08/08/2014, 18:20

... technology has been, theoretically, to increase the safety and com- pleteness of surgery in addition to increasing the confidence of the surgeon. This accounts for the increasing numbers of health ... state of the art in endoscopic sinus surgery includes many recent innovations. Prob- ably the most fundamental change in sinus surgery has been the adaptation of ri...

Ngày tải lên: 08/08/2014, 20:23

... the synovium, in ligaments especially near their insertions, in bone, in muscle, and in the outer third of the meniscus in the knee. In an unusual study in which the lead investigator became the study subject ... provided new insights into how OA may be successfully managed. The symptoms of osteoarthritis: pain and instability The pain of OA is activity-rel...

Ngày tải lên: 09/08/2014, 01:22

... consequence of the activation of many cell populations and, ultimately, of the upregulation of proinflammatory cyto- kines [19,20]. By whichever means they themselves become activated, they induce ... activity. The degree of disease activity at the start of a disease-modifying therapy is a major determinant of the disease activity attainable in treatment. Background...

Ngày tải lên: 09/08/2014, 01:22

... the definition of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) [21], the Bath Ankylosing Spondylitis Functional Index (BASFI), and the Bath Ankylosing Spondylitis Metrology ... and scientific understanding of the spondyloarthritides (SpA), which can be separated in predominantly axial and predominantly peripheral SpA. The clinical progress incl...

Ngày tải lên: 09/08/2014, 01:22

... proteins of apparently disparate function and cellular localisation. Pyrin is thought to interact with a variety of proteins within the cytoplasm and to play a key role in the modulation of inflammation ... characterised by fluctuating or irregularly recurring episodes of fever and systemic inflam- mation, affecting the skin, eyes, joints, and serosal surfaces. They in...

Ngày tải lên: 09/08/2014, 01:22

... initially present in the small joints of the feet, and appear in the small joints of the hands at a later point in the disease course [6]. Also, rheumatoid nodules are very rare in the early phases of RA, ... evaluated. Review Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets Anne...

Ngày tải lên: 09/08/2014, 10:23

... ‘Maintenance of Genome Stability’ is a biennial meeting that brings together, in a fantastic venue, diverse researchers working on how the integrity of genomes is maintained. Topics included ... extremely complex, answers to these questions will undoubtedly uncover many surprises and interesting biology that will be important in advancing our understanding of the role of ubiquit...

Ngày tải lên: 09/08/2014, 20:21

... other cytokines such as BAFF/BLyS, interleukin-17, and tumor necrosis factor- alpha (TNF-α) in the context of the local production in the in amed salivary tissues. While further insight into ... blockade of the Bcell-activating factor, the role of interferon-alpha, and targeting CD22, are discussed. â 2010 BioMed Central Ltd Challenges in understanding Sjögren’s sy...

Ngày tải lên: 12/08/2014, 17:22

... the development of delirium in critically ill patients. A recent study that used multivariate analysis [2] showed that hypertension, smoking history, abnormal bilirubin and use of morphine are associated ... change in a setting in which the incidence of delirium were lower [11]. Finally, reinclusion of patients with a history of psychosis or neurological disease (great ‘delirium mim...

Ngày tải lên: 12/08/2014, 18:21

... by macrophages and other cell types [99,100]. Therefore, one of the functions of MAP kinase signaling pathway may be to regulate the levels of cytokines or interleukines, thereby controlling cell mitosis in ... Access Review Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clini...

Ngày tải lên: 13/08/2014, 13:20

... double-strand breaks. Abundant acetylation of lysine 56 (K56) of histone H3 is found predominantly in newly syn- thesized histones that are incorporated into nucleosomes during S phase of the cell cycle, ... facilitate transcription from cryptic promoters. Mellor also introduced the idea that many of the epigenetic marks analyzed by researchers are dynamic, as illustrated by data from the MET...

Ngày tải lên: 14/08/2014, 16:21

... asso- ciated with the cyclin/cyclin-dependent kinase pathway was identified. The combination of RNAi and gene- expression profiling pro- vides further insight into gene function and the regulatory networks ... Using flow cytometry, Björklund and col- leagues analyzed the RNAi-induced loss -of- function of 70% of the genes in Drosophila, including those conserved in...

Ngày tải lên: 14/08/2014, 17:22