Báo cáo y học: "Two different genomes that produce the same result" docx

... say it was the very first, but nearly 45 years ago, George Streisinger and his colleagues mutated the lysozyme gene of phage T4 with acridine, which they knew caused frameshifts, and then they ... formation of the stalk and the synthesis of a purple dye in the spore mass. Both species aggregate by chemotaxis toward sources of cAMP. The high synchrony of development makes the...

Ngày tải lên: 09/08/2014, 20:21

... compared its activity to the activity of Exon2-luc in transient transfection assays. The mutation led to complete loss of activity in these assays, indicating that the integrity of the AUG is crucial ... oligo(dT) primer was used in the previous study. We also show that the ratio between the two E2F6 mRNAs does not change significantly during the cell cycle. The E2F6b pro...

Ngày tải lên: 08/03/2014, 09:20

... in the psycho- pathology of addiction, but also taking into account symptoms and syndromes that are under the threshold for the definition of an additional mental disorder, although they may have ... specific therapeutic action displayed by opioid agents on psychopathological symptoms. In the present report we compared the effects of buprenorphine and methadone on the psychopath...

Ngày tải lên: 09/08/2014, 01:21

... antiplatelet therapy and this likely played a role in the observed MACE events. Also noteworthy was the observation that, the lesion and the stent lengths recorded in our study were significantly longer ... methods. The operators were free to use the stent ap- proach and either the ZES or PES stent that they con- sidered to be best. Study End Points and Definitions The...

Ngày tải lên: 25/10/2012, 11:18

... organism but conventionally have to fulfil the criteria estab- lished by Murray [24] including: antibiotic safety, thermostability, hypoallergenicity, water solubility, adequate bactericidal ... arthro- plasty for periprosthetic infection recently and con- cluded that incorporation of liquid gentamicin in bone cement spacers led to effective drug delivery with systemic safety. The...

Ngày tải lên: 26/10/2012, 09:53

... replacement of selenocysteine by cysteine greatly reduces the activity of the enzyme [12]. According to Eshdat et al. [13], this would result in a plant activity lower by three orders of magnitude ... [25]. The small size and hydrophobic surface of these proteins can explain that PHGPXs (GPX4) are unique in their activity towards hydroperoxides integrated in membranes [29], suggesting...

Ngày tải lên: 08/03/2014, 22:20

... a ÔnormalÕ cyanobacterial phytochrome. The loss of the phytochrome-like absorbance during affinity chromatogra- phy of the CphB/PCB complex, taken together with the absolute stability of the point-mutated ... in cyanobacteria and other, nonphotosynthetic prokaryotes. The discovery of proteins with sequence similarity and the capability to bind tetrapyrrole chromophores in a manne...

Ngày tải lên: 08/03/2014, 23:20

... These confirmed that in the refined crystal geometry the drug is rather too tightly packed against the G19 base. The interaction can be improved by locally relaxing the drug geometry, but no hydrogen ... two orientations fitting the electron density equally well, one can conclude that both orientations in the minor groove are energetically very similar, or that the resoluti...

Ngày tải lên: 24/03/2014, 04:21

... prepared and plated on the appropriate agar plates and incubated for 24 h. Hemolytic activity of synthesized Japanese floun- der hepcidins The hemolytic activity of the synthetic Japanese flounder hepcidins ... indicated that both hepci- din genes were present as single copies in the genome because the hybridized DNA bands were the same size in both the genomic DNA and the B...

Ngày tải lên: 30/03/2014, 20:20

... Two different types of malignant fibrous histiocytomas 171 histiocytoid cells. Inflammatory-type tumors showed bizzare histiocytoid cells concealed by inflammatory cells, including lymphocytes, ... supported the hypothesis that these tumor cells are derived from true histiocytes [8,9]. Several other studies have suggested that the immunohistologic heterogenity of MFH tumor cells...

Ngày tải lên: 07/08/2014, 23:22