Báo cáo y học: "Characterizing regulatory path motifs in integrated networks using perturbational data" pdf

... 14 Pathicular, a Cytoscape plug -in for detecting path motifs We developed a Cytoscape [16] plug -in 'Pathicular' to iden- tify path motifs between cause-effect pairs in integrated physical ... integrating perturbational expression data with transcriptional, protein-protein and phosphorylation networks. Pathicular searches for &apos ;regulatory path motifs& apo...

Ngày tải lên: 09/08/2014, 20:21

... bias in assignment of treatment by a physician. ‘Confounding by indication’ means that certain treatments are preferentially given to sicker patients and certain treatments preferentially to ... of newer drugs including biological agents; these are now being pursued by pharmaceutical industry, which has set up several surveillance databanks. In addition to monitor- ing for safety, these d...

Ngày tải lên: 09/08/2014, 01:23

... gain insight into the signaling pathway activated by HNE in human OA osteoblasts, we first examined the HNE-induced phosphorylation patterns of MAPKs over increasing periods of time. Our data indicated ... enzyme inhibition, and activation of stress- signaling pathways via transcription factors and protein kinase pathways, as well as inhibition of the nuclear factor-κB (NF- κB) signaling pa...

Ngày tải lên: 09/08/2014, 08:22

... H, Hyldstrup L; the TIRA group: Bone loss in unclassified polyarthritis and early rheumatoid arthritis is better detected by digital X-ray radiogrammetry than dual energy X-ray absorptiometry: ... course of progression during the early years of disease, and therefore it has been recommended that conventional imaging of the hands and feet be done every year during the initial period after RA...

Ngày tải lên: 09/08/2014, 10:22

... breathing in genetically obese (ob/ob) mice. J Appl Physiol 1996, 81(2):716-723. 58. Inyushkin AN, Inyushkina EM, Merkulova NA: Respiratory responses to microinjections of leptin into the solitary tract ... of leptin in the lung [8]. Accumulated evidence suggest that leptin may be involved in the local inflammatory response seen in the airways of COPD patients, hypothetically regulati...

Ngày tải lên: 12/08/2014, 11:23

... ELISAs displayed intra-assay variability ranging from 2.3% to 4.1% and inter-assay variability ranging from 7.4% to 10.3%. The anti- b2 GPI IgG and IgM ELISAs revealed intra-assay variability from ... monoclonal antibody; MLDA: multi-line dot assay; NHS: normal healthy subjects; PI: phosphatidylinositol; PS: phosphatidylserine; PVDF: polyvinylidene difluoride; ROC: receiver-operating acharact...

Ngày tải lên: 12/08/2014, 17:22

Ngày tải lên: 13/08/2014, 01:20

... CLDN- 7-associated protein may not be correspondingly increased. Therefore, addition of CLDN-7 to 293T cells can only partially increase levels of HIV infectivity, approximately 10% of that of LNCaP ... that is highly susceptible to HIV infection to another cell line that has low susceptibility. By screen- ing membrane proteins that are specifically expressed in the cell line highly suscept...

Ngày tải lên: 13/08/2014, 09:21

... FLLG motifs are found in b1,3-GalTs and b1,3-N-acetylglucosaminyltransferases, thereby suggesting that they are more likely involved in mediating the b1,3-linkage speci®city r ather than in t ... reaction [2,3]. Also, the grouping by similarity may bring together glycosyl- transferases with a distinct s ubstrate speci®city, thereby providing some insight into the possible evolution fr...

Ngày tải lên: 08/03/2014, 16:20

... N -terminal r egion of the cytoplasmic domain. K inases in the Src family, such as Lyn phosphorylate tyrosine residues in ITAM and phosphorylated ITAM, recruit Syk via the SH2 domain to initiate ... are now easy to use, and the above method should p rove useful for finding regulatory regions in long intergen ic regions and introns. Well studied in chicken b-globin [34] and lysozyme [...

Ngày tải lên: 24/03/2014, 03:21