Báo cáo y học: " Tracing the evolution of tissue identity with microRNAs" ppt

... nemertodermatids). Acoels were originally grouped within the phylum Platyhelminthes but have recently been placed at a key position at the base of the Bilateria on the basis of new molecular data [9] (Figure ... complexity [3-7]. It is not clear, however, how exactly novel miRNAs evolve and what roles they have in the establishment of tissue identity. According to th...

Ngày tải lên: 09/08/2014, 20:21

... multiplicity of different biological pathways. For the most part, the organization and function of these aging-related pathways remain poorly understood. In particular, the role of most longevity genes in ... < 10 -6 ). For the Budovskaya et al. study [21], subnetwork seeds were highly enriched for known longevity genes, and the set of all subnetwork genes was slightly en...

Ngày tải lên: 09/08/2014, 20:21

... anticipated. These factors significantly reduced the power of the study. Based on their findings, the authors estimate that more than 100 hospitals would be needed to show the 30% difference they sought. ... goal of identifying and treating patients early in the course of their illness is preferable to waiting until more serious signs and symptoms have developed. Certain...

Ngày tải lên: 25/10/2012, 10:39

... replacement of Gly261 by Ala in mutant G261A resulted in an enzyme with slightly lower stability. On the other hand, in the double mutant G261A /Y2 69A the additional replacement of Tyr269 by Ala restores ... although the HGGG loop was a critical structural element for the catalytic efficiency of the enzyme, the cold adaptation of the enzyme could not be attributed to...

Ngày tải lên: 22/02/2014, 04:20

... the content of secondary structure only after the disruption of the native tertiary structure of RNase A (Figs 2–4). Interestingly, the preservation of the tertiary structure coincides with the ... triflu- oroethanol the proteolytic susceptibility of RNase A strongly increases, which coincides with the disruption of the tertiary structure of the RNase A mo...

Ngày tải lên: 22/02/2014, 07:20

... studying the catalytic efficiency for these mutants in the diaphorase reaction, all of them yield values very close to those of the wild-type enzyme at the different ionic strengths assayed (within ... FNR the side-chain of E139 might influence the properties of the flavin, assuming some of the functions carried out by E301 in the wild-type enzyme [22]. In this contex...

Ngày tải lên: 31/03/2014, 08:20

... complement of chromosomes. The fidelity of chromosome transmission is enhanced not only by the geometry of stable centromere–MT interac- tions, but also by the action of a centromere-based regulatory system ... way, the critical connections that hold sisters together from S phase through early mitosis are literally cut by Ômolecular scissorsÕ in the form of Esp1/separase at...

Ngày tải lên: 31/03/2014, 21:21

... for the clinician to be comfortable with the side-effect profile and be able to discuss potential safety concerns regarding these therapies. Among the safety concerns with the use of INCs are the ... for the clinician to be comfortable with the- side effect profile and be able to discuss potential safety concerns regarding these therapies. Among the safety concerns wit...

Ngày tải lên: 08/08/2014, 21:20

... 1 Institute of Psychiatry, University of Bologna, Italy, 2 Department of Psychology, Catholic University, Milan, Italy and 3 Department of Psychiatry, San Raffaele Scientific Institute, Milan, Italy Email: ... bipolar disorder of Mr. A daughter strengthen the genetic hypoth- esis. On the contrary, only Mrs. B mother aunt was affected by depression and anxiety, pharmacologica...

Ngày tải lên: 08/08/2014, 21:20

... for ankylosing spondylitis and rheumatoid arthritis, an absence of fibromyalgia, and a temporal increase in the prevalence of gout. What should we make of all of these estimates and why are they important ... rheumatic diseases vary in prevalence by age. An additional source of Editorial Comparing the prevalence of rheumatic diseases in China with the rest of the world...

Ngày tải lên: 09/08/2014, 10:22