Báo cáo y học: " Tracing the evolution of tissue identity with microRNAs" ppt
Báo cáo y học: " Tracing the evolution of tissue identity with microRNAs" ppt
... nemertodermatids). Acoels were originally grouped within the phylum Platyhelminthes but have recently been placed at a key position at the base of the Bilateria on the basis of new molecular data [9] (Figure ... complexity [3-7]. It is not clear, however, how exactly novel miRNAs evolve and what roles they have in the establishment of tissue identity. According to the model of transcriptional control of ... respectively. The summary for the BLCA is preliminary owing to the absence of a sequenced acoel genome and miRNA expression data. Representatives of the taxa used in the study of Christodoulou...
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Báo cáo y học: " Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegans aging" pps
... multiplicity of differentbiological pathways. For the most part, the organization andfunction of these aging-related pathways remain poorlyunderstood. In particular, the role of most longevity genesin ... <10-6). For the Budovskaya et al. study [21], subnetworkseeds were highly enriched for known longevity genes, and the set of all subnetwork genes was slightly enriched forthem. Of the 1,559 seed ... significantly enriched for subnetworkgenes. To test whether these pathways and processes werealso related to aging, we calculated the significance of theiroverlap with the set of experimentally determined...
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Báo cáo y học: "Demonstrating the benefit of medical emergency teams (MET) proves more difficult than anticipated"
... anticipated. These factors significantly reduced the power of the study. Based on their findings, the authors estimate that more than 100 hospitals would be needed to show the 30% difference they sought. ... goal of identifying and treating patients early in the course of their illness is preferable to waiting until more serious signs and symptoms have developed. Certainly, at the University of ... benefit for MET may take longer than the 6-month period of this study. Contamination of control hospitals also may have been an issue. Though they did not receive the study-based educational...
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Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf
... replacement of Gly261 by Ala in mutantG261A resulted in an enzyme with slightly lower stability.On the other hand, in the double mutant G261A /Y2 69A the additional replacement of Tyr269 by Ala restores ... although the HGGG loop was acritical structural element for the catalytic efficiency of the enzyme, the cold adaptation of the enzyme could not beattributed to the presence of the Gly cluster ... study [16],our interest is focused to the vicinity of the active site of the psychrophilic alkaline phosphatase from the AntarcticTable 1. Enzymatic and thermodynamic parameters of the psychrophilic...
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Tài liệu Báo cáo Y học: Dissecting the effect of trifluoroethanol on ribonuclease A Subtle structural changes detected by nonspecific proteases ppt
... the content of secondary structure only after the disruption of the native tertiary structure of RNase A(Figs 2–4). Interestingly, the preservation of the tertiarystructure coincides with the ... triflu-oroethanol the proteolytic susceptibility of RNase Astrongly increases, which coincides with the disruption of the tertiary structure of the RNase A molecule, in 20%trifluoroethanol the proteolytic ... hydro-chloride (GdnHCl), urea or elevated temperatures, theydestroy the tertiary structure of proteins which results in the loss of enzymatic activity. Regarding the secondary struc-ture of...
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Báo cáo Y học: Probing the role of glutamic acid 139 of Anabaena ferredoxin-NADP+ reductase in the interaction with substrates pptx
... studying the catalyticefficiency for these mutants in the diaphorase reaction, all of them yield values very close to those of the wild-typeenzyme at the different ionic strengths assayed (within ... FNR the side-chain of E139 might influence the properties of the flavin, assuming some of the functionscarried out by E301 in the wild-type enzyme [22]. In thiscontext, a special reactivity of the ... pro-duced with the mutated enzyme. These results areconsistent with those obtained upon analysing the kobsfor the fast kinetic reduction of FNR by NADPH, whichindicate that all of the E139...
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Báo cáo Y học: Beyond the ABCs of CKC and SCC Do centromeres orchestrate sister chromatid cohesion or vice versa? potx
... complement of chromosomes. The fidelity of chromosome transmission is enhanced notonly by the geometry of stable centromere–MT interac-tions, but also by the action of a centromere-basedregulatory system ... way, the critical connections that hold sisterstogether from S phase through early mitosis are literally cutby Ômolecular scissorsÕ in the form of Esp1/separase at the onset of anaphase. The ... really the case, giventhat cohesion proteins and cell cycle machinery are widelyconserved. The apparent differences might simply reflect the timing with which different organisms assemble theirmitotic...
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Báo cáo y học: "Evaluating the Safety of Intranasal Steroids in the Treatment of Allergic Rhinitis" docx
... for the clinician to be comfortable with the side-effect profile and be able to discuss potential safety concerns regarding these therapies.Among the safety concerns with the use of INCs are the ... for the clinician to be comfortable with the- side effect profile and be able to discuss potentialsafety concerns regarding these therapies. Among the safety concerns with the use of INCs are the ... allergies are ‘ the most commonchronic condition in Canadians 12 years of age andolder.’’1In one study, 42% of children were diagnosed with AR by the age of 6 years. The prevalence of AR hasincreased...
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Báo cáo y học: "Dissecting the determinants of depressive disorders outcome: an in depth analysis of two clinical cases" pot
... 1Institute of Psychiatry, University of Bologna, Italy, 2Department of Psychology, Catholic University, Milan, Italy and 3Department of Psychiatry, San Raffaele Scientific Institute, Milan, ItalyEmail: ... bipolardisorder of Mr. A daughter strengthen the genetic hypoth-esis. On the contrary, only Mrs. B mother aunt wasaffected by depression and anxiety, pharmacologicallytreated. Therefore, the genetic ... composure.From the age of forty-five years old other three depressiveepisodes followed, concomitant with stress in the com-pany context. These three episodes, with similar symp-tomatology of the first,...
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Báo cáo y học: "Comparing the prevalence of rheumatic diseases in China with the rest of the world" pptx
... forankylosing spondylitis and rheumatoid arthritis, an absence of fibromyalgia, and a temporal increase in the prevalence of gout. What should we make of all of these estimates and whyare they important ... rheumaticdiseases vary in prevalence by age. An additional source of EditorialComparing the prevalence of rheumatic diseases in China with the rest of the worldDavid T FelsonClinical Epidemiology Research ... regardingrheumatic disease etiology.Zeng and colleagues reviewed diverse studies, many of themusing the Community Oriented Program for the Control of Rheumatic Diseases (COPCORD) protocol. The COPCORDhas been...
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