Báo cáo y học: "Genomic features defining exonic variants that modulate splicing" ppt

... efficiency decreases [43]. Indeed, we found that ESS density of many SAV exons was more comparable to that of introns than exons. As weakly defined exons, they appear vulnerable to variants that ... D, He M, Berry SA, Rinaldo P, Whitley CB, Madsen PP, van Calcar SC, Lussky RC, Andresen BS, Wolff JA, Vockley J: Prospective diagnosis of 2- methylbutyryl-CoA dehydrogenase deficiency in t...

Ngày tải lên: 09/08/2014, 20:21

... Biochem. 269) 3639 proliferative pathway. These hypotheses remain to be verified. We are studying to find out if some MUC4 variants are very rare and occur only in specific tissues at specific times ... m M deoxyribonucleoside triphosphates, 10 pmol of each primer and 2 U of Taq DNA polymerase (Roche diagnostics, Meylan, France). The cycle parameters were 94 °C for 4 min, followed by 30 cycles...

Ngày tải lên: 17/03/2014, 23:20

... (HMFN0839)* 1-Acylglycerol-3-phosphate O-acyltransferase 9 [GenBank:NM_032717.3 ] 34 MTHFD2 Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase [GenBank:NM_006636.3 ] 35 ... an individual sample. Supervised analysis The aim of the supervised analysis is to identify probes that are differentially expressed between study groups and that migh...

Ngày tải lên: 09/08/2014, 20:20

... overall similarity to Y. enterocolitica: Y. kristensenii, Y. frederiksenii, Y. mollaretii, Y. intermedia, Y. bercovieri, Y. aldovae, Y. rohdei, Y. ruckeri, Y. pseudotuberculosis, and Y. pestis. The ... 17:434-464. 25. Wang X, Han Y, Li Y, Guo Z, Song Y, Tan Y, Du Z, Rakin A, Zhou D, Yang R: Yersinia genome diversity disclosed by Yersinia pestis genome-wide DNA microarray. Can...

Ngày tải lên: 09/08/2014, 20:21

... money (especially when it partially duplicates other resources) and unclear how any particular information resource will survive beyond a single funding cycle. In addition, like many other ... intensity of informatics in biological research, with bio informatics becoming a necessary component of many, if not most, molecular biology groups. e analysis of new genome- wide experiments ty...

Ngày tải lên: 09/08/2014, 20:22

... literature. Phylogenetic analysis using both aCGH and MLST data revealed that the variant Bt strains occupy part of an evolutionary clade that is genetically distinct from the majority of Bt strains. ... is generally regarded as an essen- tial mammalian virulence factor [25]. Analysis of the Bp-likeCPS genes revealed that they are highly d istinct from preexisting polysaccharide synthes...

Ngày tải lên: 09/08/2014, 20:22

... 4-amino-3-hydroxybenzoate cleavage. I, 4-amino-3-hydroxybenzoic acid; II, 2-amino-5-carboxymuconic 6-semialdehyde; III, 2-hydroxymuconic 6-semialdehyde; IV, 2,5- pyridinedicarboxylic acid. (B) Pathway ... and that 2-amino- 5-carboxymuconic 6-semialdehyde is then converted to 2,5-pyridinedicarboxylic acid nonenzymatically (Fig. 4A). Therefore, we named the enzyme reported here 4-amino-3- hyd...

Ngày tải lên: 21/02/2014, 01:21

... Chang, C., Eom, S.H., Hwang, K .Y. & Cho, Y. , Yu, Y. G., Ryu, S.E., Kwon, S.T. & Suh, S.W. (2000) Crystallization and preliminary X-ray crystallographic analysis of NAD + -dependent DNA ligase ... Hakansson,K.,Doherty,A.J.,Shuman,S.&Wigley,D.B.(1997) X-ray crystallography reveals a large conformational change during guanyl transfer by mRNA capping enzymes. Cell 89,545– 553. 31....

Ngày tải lên: 21/02/2014, 01:21

... sequence. mRNA species that contain premature termination codons are often destroyed by nonsense mediated decay so that only full-length proteins are produced [17]. However, not all mRNAs that contain ... usually not compatible with normal CAP-dependent ribosomal scanning. In conclusion, these data strongly suggest that E2F6b is initiated by internal ribosome entry. We noted that in...

Ngày tải lên: 08/03/2014, 09:20

... assumption that all other natively unfolded proteins may possess the same property. In fact, the analysis of hydrodynamic data s hows t hat two of the three consid ered proteins (a-synuclein and prothymosin ... and/or mean hydrophobicity of the protein could c hange t hese parameters in such a way that they will approach values typical of folded native proteins. This hypothesis has been c...

Ngày tải lên: 08/03/2014, 16:20