Báo cáo y học: "A fuzzy gene expression-based computational approach improves breast cancer prognostication" doc

... Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures. Breast Cancer Res 2008, 10:R65. 10. Babuska R: Fuzzy ... positive subtypes. Here we present Gene Expression Prognostic Index Using Subtypes (GENIUS), a fuzzy approach for prognostication that takes into account the molecular h...

Ngày tải lên: 09/08/2014, 20:21

... used to analyze microarray data and to find useful genes for classifying samples. Pathway analysis suggests that BMI is successful in identifying biomarker-quality cancer- related genes from the ... microarray technology can be used to identify genes whose expression profile in a type of cancer differs from normal tissues or from other types of cancer. Such biomarkers are important since...

Ngày tải lên: 10/08/2014, 09:22

... resource availability, and situational fac- tors. It seems unlikely that there is one best way to achieve these goals; at the same time, it seems unlikely that all ways are always equally effective. ... and validity. As two recently published reviews indicate, most of the instru- ments employed in peer-reviewed research were not developed systematically using theory, nor were they sub- jected...

Ngày tải lên: 11/08/2014, 05:21

... of physical activity programs in comprehensive, complementary treatment regimes for breast cancer patients in Italian oncology departments. Key words: Physical exercise, quality of life, breast ... of life, breast cancer survivors, Italian Oncology INTRODUCTION Physical activity has many and varied effects on the human body. The physiological effects of physical activity and e...

Ngày tải lên: 08/08/2014, 16:23

... ubiquitin-conjugating enzyme E2C -2.5 NM_001071 TYMS thymidylate synthetase -2.3 NM_053056 CCND1 cyclin D1 (PRAD1: parathyroid adenomatosis 1) 3 -2.0 NM_002466 MYBL2 v-myb myeloblastosis viral oncogene homolog ... Nakayama K, Moriyama M, Iwanari O, Katabuchi H, Okamura H, Sakai E, Miyazaki K. Thymidine kinase in epithelial ovarian cancer: relationship with the other pyrimidine pathw...

Ngày tải lên: 08/08/2014, 17:20

... polymorphisms in lymphotoxin-α gene. Am J Hypertens. 2004; 17: 1045-9. 11. Sano M, Kuroi N, Nakayama T, et al. The association study of calcitonin-receptor-like receptor gene in essential hypertension. ... an- tihypertensive drugs. All EH subjects had a positive family history of hypertension; patients diagnosed with secondary hypertension were excluded from the study. We also enroll...

Ngày tải lên: 26/10/2012, 10:04

... (MPPKPDNPSSDASPEELSKYMLAVR NYINLITRQRY-NH 2 ), PYY (FPPKPDNPGDNASPEQM ARYKAAVRHYINLITRQRY-NH 2 ) and NPY (FPNKPDS PGEDAPAEDLARYLSAVRHYINLITRQRY-NH 2 were synthesized by solid-phase methodology on a 0.025-mmol scale ... relayed by a family of G-protein coupled receptors [8–10]. Five receptors have been cloned in mammals; Y1 , Y2 , Y4 , Y5 and y6 , most of which have high affinities for NPY...

Ngày tải lên: 31/03/2014, 23:20

... extremely promising results [9–18]. Indeed, a phase I human study of IL-1Ra gene therapy in RA [19] was recently successfully completed. During the preclinical development of IL-1Ra gene therapy, ... may be key to realizing the full therapeutic potential of this mater- ial. Gene delivery may offer the greatest chance of early success. Recent data from our laboratory have shown that the...

Ngày tải lên: 09/08/2014, 01:23

... Atelosteogenesis type II is caused by mutations in the diastrophic dysplasia sulfate-transporter gene (DTDST): evidence for a phenotypic series involving three chondrodysplasias. Am J Hum Genet ... associated with a phenotype, but still there are usually many genes within such a region that might be possi- ble candidates. Specifically, when employing QTL analysis in rats, selecting gene c...

Ngày tải lên: 09/08/2014, 06:22

... probability test; OR = 8.21, 95% CI = 1.77–38.04). In the polyarthritis and systemic subgroups, the frequency of haplotype S01 did not differ statistically from that of healthy controls. The frequency ... liver dysfunction, splenomegaly and hyper ferritinemia [12]. Although serum levels of inflammatory cytokines are generally high in AOSD patients [13], the levels of IL-18 were enormously hig...

Ngày tải lên: 09/08/2014, 07:20