Báo cáo y học: " Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegans aging" pps

... Fortney et al., Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegans aging Genome Biology 2010, 11:R13 Fortney et al. Genome Biology 2010, 11:R13 http://genomebiology.com/2010/11/2/R13 Page ... original work is properly cited. Method Inferring the functions of longevity genes with modular subnetwork...

Ngày tải lên: 09/08/2014, 20:21

... anticipated. These factors significantly reduced the power of the study. Based on their findings, the authors estimate that more than 100 hospitals would be needed to show the 30% difference they sought. ... goal of identifying and treating patients early in the course of their illness is preferable to waiting until more serious signs and symptoms have developed. Certain...

Ngày tải lên: 25/10/2012, 10:39

... the management of patients have a sound grasp of at least the basics of statistical methods. Unfortunately, in practice this is often not true, with many relying on distant memories of poorly ... Although some of the topics covered in this series will probably be familiar, it is hoped that there will still be useful lessons to be learned, for example the underlying assumpt...

Ngày tải lên: 25/10/2012, 10:45

... hepatobiliary system, genitourinary system, reproductive system, CNS and psychiatric conditions, and then to specify the name of that con- dition. If the participant failed to indicate the name of the ... pathways, the “voluntary path” and the “involuntary path” otherwise known as the “emotionally-driven path”. (5) The voluntary path- way begins from the premotor ope...

Ngày tải lên: 26/10/2012, 09:57

... Frequency of the MTHFR genotypes and the result of the Chi square testing in the different studied groups. Showing the frequency and the results of the cross tabulation of the T allele and the different ... the thermolability of MTHFR. Actually, the frequency of the mutated allele was quite high, depending on the ethnic group analyzed [18-21]. Some au...

Ngày tải lên: 03/11/2012, 09:49

... replacement of Gly261 by Ala in mutant G261A resulted in an enzyme with slightly lower stability. On the other hand, in the double mutant G261A /Y2 69A the additional replacement of Tyr269 by Ala restores ... although the HGGG loop was a critical structural element for the catalytic efficiency of the enzyme, the cold adaptation of the enzyme could not be attributed to...

Ngày tải lên: 22/02/2014, 04:20

... the content of secondary structure only after the disruption of the native tertiary structure of RNase A (Figs 2–4). Interestingly, the preservation of the tertiary structure coincides with the ... triflu- oroethanol the proteolytic susceptibility of RNase A strongly increases, which coincides with the disruption of the tertiary structure of the RNase A mo...

Ngày tải lên: 22/02/2014, 07:20

... formation of 16a-hydroxyprogesterone. Both expressed enzymes had no lyase activity towards PROG or 17-OHPROG. Understanding of the complexity of hydroxylase and lyase activity of CYP17 by way of primary ... 17a-hydroxylase (CYP17) cata- lyses not only the 17a-hydroxlation of pregnenolone and progesterone and the C17,20-side chain cleavage (lyase) of 17a-hydroxypregnenolone...

Ngày tải lên: 08/03/2014, 09:20

... residue for the final family is given in Fig. S1. Fig. 3A shows the family of 40 structures and Table 1 contains a summary of statistical data indica- ting the quality of the 40 models and the average ... residues. Analysis of the distribution of the electrostatic potential on the surface of the molecule reveals the ampiphilic character of the helix (Fig. 4A...

Ngày tải lên: 17/03/2014, 10:20

... initiated by the lysis of a water molecule in the cytoplasmic phosphorylation site, implying that the proton pathway would begin close to the phosphorylated aspartate (Asp378). The major steps o f the ... catalytic activity proceed essentially by the same mechanism. Indeed, catalytic residues occupy the same position in the 3D structures of the two enzymes. In addition...

Ngày tải lên: 23/03/2014, 21:20