Báo cáo y học: " PRDM9 points the zinc finger at meiotic recombination hotspots" potx

... meiotic recombination by the same evolutionarily conserved process: DNA double-strand break (DSB) formation catalyzed by the topo-isomerase-like protein Spo11 (reviewed in [1]). us, all meiotic ... (the only known H3K4 methyltransferase activity in yeast) causes dramatic changes in the pattern of hotspot usage across the yeast genome [5], suggesting that H3K4me3 is an evolutionarily conserved ... histone methyltransferase, PRDM9, determines their distribution.© 2010 BioMed Central Ltd PRDM9 points the zinc ﬁnger at meiotic recombination hotspotsMatthew J Neale*R E SEA RCH H IGH LIG HT*Correspondence:...

Tài liệu Báo cáo Y học: Systematic search for zinc-binding proteins in Escherichia coli potx

... i.e. catalytic and structural. The catalytic role speciﬁes that zinc participates directly inenzyme catalysis, while structural zinc atoms are requiredfor stabilization of proteins by supporting ... 1,6-bisphosphatasealdolase4 GlyA Serine hydroxymethyltransferase5 LpdA* (AtpA) Lipoamide dehydrogenase(F1 ATP synthase a subunit)6 Ppa* (AhpC) Inorganic pyrophosphatase(alkyl hydroperoxide ... acetate kinase(AckA) that is known to require the metal for expression of the catalytic function [29], DnaK that is considered to carry zinc as in the case of DnaJ [30,31], and serine hydroxymeth-yltransferase...

Báo cáo y học: "Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus" pps

... ofhypersensitivity [5]. The major metabolic pathway for sulpham-ethoxazole is catalyzed by N-acetylation by N-acetyltrans-ferase 2 (NAT2). In the pathogenesis of hypersensitivity, the formation ... haplo-types exhibit the slow acetylator phenotype, whereas thosewho carry at least one wild-type haplotype exhibit the fastacetylator phenotype.In the present study we examined the association ... population,namely NAT2*4, NAT2*5B, NAT2*5E, NAT2*6A, NAT2*7Band NAT2*13. Of these, NAT2*4 is the wild-type haplotype; the remaining haplotypes are mutant types. In the presentstudy, individuals...

Báo cáo y học: "Use of the measure your medical outcome profile (MYMOP2) and W-BQ12 (Well-Being) outcomes measures to evaluate chiropractic treatment: an observational study"

... negative correlation with the GWB, a moderatenegative correlation with the PWB and Energy scalesand a positive moderate correlation with the Negativewellbeing scale. The Activity scale of the ... utilised for the study.Patients were invited to participate in the study if theywere: over the age of 18 years; had no treatment fromany health professional for their complaint in the preced-ing ... step forwards to assess the utility of thesequestionnaires in another practice setting.Therefore the aim of this observational study was toassess the utility of the MYMOP2 and W-BQ12 healthoutcomes...

Báo cáo y học: "Impact of the Kenya post-election crisis on clinic attendance and medication adherence for HIV-infected children in western Kenya"

... locations, assome clinics were dramatically affected and others werescarcely affected. They further noted that the quantitativedata did not adequately capture the bravery of the AMPATH patients ... them to go on the roads and try toget [to clinic]. The risks to personal safety were seen to vary based on the fam-ilies' tribal affiliation, their location, and whether they were in the ... subsequentlyentered into the AMPATH Medical Record System by ded-icated data entry clerks, with data entry validated by ran-dom review of 10% of the data entered. This system wasdesigned for...

Báo cáo y học: "Evaluation of the Prevalence of Concomitant Idiopathic Cyclic Edema and Cellulit"

... the main reason for treatment failure. When the idiopathic cyclic edema is not previously treating, the failure and early relapse rates of treat-ment for cellulite is more than 80%. Once the ... patients treated for Grade II and III cellulite were evaluated for idiopathic cyclic edema in a retrospective, quantitative and cross-sectional study. The study was carried out at the Godoy ... aggravates the symptoms of lipedema, cellulite and obesity. These data offer a new research perspective in relation to the treatment of aggravating factors in cellulite. Conclusion Idiopathic...

Báo cáo y học: "Enhancement of the Click Chemistry for the Inverse Diels Alder Technology by Functionalization of Amide-Based Monomers"

... showed the product at m/e 5958.9 calc. 5958.1, the trication at m/e 1986.5 and the tetracation at 1489. The dan-syl-tetrazine could be seen at m/e 875.7. 11. Ligation of the Pentamer II with the ... employed the Fmoc-strategy [21] in a fully automated peptide syn-thesizer A433 (Perkin Elmer). The synthesis was car-ried out on a 0.05 mmol Tenta Gel R Ram (Rapp Polymere) 0.19 mmol/g by substitution. ... restricting the ligation efficiency. The ligation starts with the chemical reaction of the Reppe Anhydride derivative monomer 3, the reaction partner with the higher reactivity. After completion, the...

Báo cáo y học: " Efficacy of the Valsalva Maneuver on Needle Projection Pain and Hemodynamic Responses During Spinal Puncture"

... to the third minutes after that were statistically different between the study groups (P= 0.016). Post Hoc Tukey test showed there was statistical difference in HR between the ball and the ... ringer lac-tate solution. Spinal anesthesia was performed in lat-eral position by 25-guage Quincke needle without introducer. The puncture pain was assessed by the patients, immediately after ... EMLA patch. Local anesthetics themselves may pro-duce pain on injection and many anesthetists are un-sure that infiltration analgesia at the site of spinal puncture has any advantage over a straightforward...

Báo cáo y học: "Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistyr"

... thin layer chromatography. The reaction prod-uct was inspissated by the rotary evaporator and consecu-tively und covered with ether. The product 16 precipitates voluminously, depending on the ... constantly. In the process the reaction solutions colour changes to yellowish. The reaction batch was stirred continuously over night and concentrated by the rotary evaporator. The yellow residue ... n-hexane and acetic ether were used at the ratio of 2:1. The purity was estimated by use of thin-layer chromatography. Cleavage of the tert-butyl ester. 2 mmol tert-butyl pro-tected PNA building...

Báo cáo y học: " Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic approac"

... of the cytoch-rome P450 (CYP) enzymatic system, is responsible for the metabolism of tacrolimus [10]. Specifically; tacro-limus is mainly metabolized by CYP3A4 and CYP3A5 enzyme isotype. CYP3A5 ... predict the amount of CYP3A5 protein accurately as it can be affected by other factors, genetic (expression of m-RNA, stability of CYP3A5 protein, dual metabolic pathway via CYP3A4 and CYP3A5, ... GLM repeated measures approach seems to be a more accurate me-thodology for the analysis of such data but it is more demanding in the quantity of available data. In the LR analysis, the kinetic...

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