Báo cáo y học: "Integrating phenotype ontologies across multiple specie" pps

... Biological Ontologies; OWL: Web Ontology Language; PATO: Phenotype and Trait ontology, an ontology of phenotypic qualities; PRO: Protein Ontology; WP: Worm Phenotype ontology (sometimes WBPhenotype); ... majority of all mapped phenotype classes fall into this category. This holds across all phenotype ontologies, but particularly for HP, which is by nature highly morpho- logical....

Ngày tải lên: 09/08/2014, 20:21

... cell cycle-regulated genes of the yeast Saccharomyces cer- evisiae by microarray hybridization. Mol Biol Cell 1998, 9:3273-3297. 7. Allison DB, Cui X, Page GP, Sabripour M: Microarray data analy- sis: ... J, Pavlidis P: Coexpression analysis of human genes across many microarray data sets. Genome Res 2004, 14:1085-1094. 21. Huttenhower C, Hibbs M, Myers C, Troyanskaya OG: A scalable method...

Ngày tải lên: 09/08/2014, 20:21

... are exclusively discovered by each data type. Figure 3B shows the additional sets discovered by integrative and meta-analytic approaches but not by any of the single-data-type analyses (see Methods ... pathway may be sufficient to generate a phenotypic difference. If this hit can occur in any of several components in the pathway, individuals with the same phenotype may show variability...

Ngày tải lên: 09/08/2014, 23:20

Ngày tải lên: 08/08/2014, 20:23

... manuscript is sponsored by University of Calgary. Received: 29 May 2010 Accepted: 28 July 2010 Published: 28 July 2010 References 1. Davis AE III: The pathophysiology of hereditary angioedema. Clin ... University, Hershey, Pennsylvania, USA. 4 Johann Wolfgang Goethe University, Frankfurt/Main, Germany. 5 Department of Immunology, Plymouth Hospitals NHS Trust, UK. 6 Dept of Internal Medicin, R...

Ngày tải lên: 08/08/2014, 21:20

... the lowest dose which confers adequate prophylaxis, typi- cally 2 mg stanozolol daily or every other day or 200 mg danazol daily or every other day. Detailed recommenda- tions for dose titration ... kinino- gen(HMWK)[58].Thereleasedbradykininmoiety potently increases vascular permeability by binding to its cognate receptor (the bradykinin B2 receptor) on vascular endothelial cells. The discov...

Ngày tải lên: 08/08/2014, 21:20

... depression display a true comor- bidity or only share similar symptoms [41]. Typically, patients with severe depressive symptoms should be referred to a psychiatrist, particularly if such symptoms do not ... extent to which daytime functioning is affected gener- ally depends on the severity of OSA. Symptoms other than EDS which greatly impact daytime functioning are neu- ropsychological sympt...

Ngày tải lên: 08/08/2014, 21:20

... systems to study chondrocyte biology on proinflam- matory stimuli [10,73]. For the in vitro analysis of cartilage destruction in RA, interactions between (a) chondrocytes as a single cell type ... demonstrated by alcian blue staining of cartilage proteoglycans and by antibody staining of (d) collagen type I and (e) cartilage-specific collagen type II. (f) Negative IgG control. In summary, we...

Ngày tải lên: 09/08/2014, 01:22

... mg/kg/day 6.4 mg/kg/day 3 mg/kg/day Start Onset of symptoms Onset of symptoms Onset of symptoms Duration 7 days 35 days 5 days Effect on inflammation No No No Effect on cartilage damage Yes No ... DK, Marks SC Jr, Choi Y: Diverse roles of the tumor necrosis factor family member TRANCE in skele- tal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE ....

Ngày tải lên: 09/08/2014, 01:23

... have included corticosteroids, methotrexate, sulfasalazine, cyclophosphamid, cyclosporine, leflunomide, mycophenylate, and hydroxychloroquine; newer approaches include immune-based targeting ... pathogenesis and represented in synovium/pannus [5]. The accessibility of synovial fluid has permitted the documentation of elevated levels of cytokines, including pro-inflammatory cytokines such as I...

Ngày tải lên: 09/08/2014, 06:22