Báo cáo y học: "CTCF binding site classes exhibit distinct evolutionary, genomic, epigenomic and transcriptomic features" docx

... R131 Research CTCF binding site classes exhibit distinct evolutionary, genomic, epigenomic and transcriptomic features Kobby Essien ¤ * , Sebastien Vigneau ¤ † , Sofia Apreleva ¤ * , Larry N Singh * , ... these classes of CTCF sites in terms of their genomic, epigenomic, transcriptomic, functional and evolutionary properties. Most notably, we discovered that low-oc...

Ngày tải lên: 09/08/2014, 20:21

... Organic Chemistry, University of Karlsruhe, Germany; 2 Institute for Organic Chemistry, Budapest University of Technology and Economics, Hungary The plant enzyme phenylalanine ammonia-lyase (PAL, EC ... catalysis. Keywords: phenylalanine ammonia-lyase; PAL; MIO; site- directed mutagenesis; homology model. Phenylalanine ammonia-lyase (PAL; EC 4.3.1.5) is a very important plant enzyme that...

Ngày tải lên: 08/03/2014, 23:20

... a-actin, and the a 3 subunit of Na + /K + -ATPase), stimulation of protein synthesis, and myocyte hypertrophy. The solid arrows indicate experimentally supported events induced by ouabain in myocytes, ... the mechanisms by which a variety of hormones, neurotransmitters, cytokines, mitogens, and mechanical stimuli affect cardiac myocyte hypertrophy [21]. Interestingly, in this highly act...

Ngày tải lên: 24/03/2014, 00:21

... the primary tissues affected by disease (carti- lage and synovium) and has been implicated as a contributor to disease pathophysiology, we hypothesized that proteomic analysis of SF may provide ... (Figure 2 and Table 2). Indeed, the best sensitivity and specificity for proteins in this subset was noted for complement component 3, which exhibited sen- sitivity and specificity of 90%...

Ngày tải lên: 09/08/2014, 10:20

... Takayasu’s disease, giant cell arteritis, spondylarthropathy, Behcet’s syndrome, relapsing poly- chondritis, Cogan’s syndrome, retroperitoneal fibrosis, ankylosing spondylitis, systemic lupus erythemat ... Clinical and electrophy- siological neurological investigations showed sensorimotor polyneuropathy of both lower limbs and she also displayed symptoms of depression. Antibiotic therapy...

Ngày tải lên: 10/08/2014, 09:21

... iscrepancy could lie in the fact that type II collagen is more glycosylated than type I collagen. It seems to us probable that glycosylation of hydroxylysine will block the binding. However, the glycosylation ... location and the relative o rientation of the binding sites in decorin and collagen are not yet known. Our findings on multiple binding sites in collagen and on the relevan...

Ngày tải lên: 21/02/2014, 15:20

... extracted with SDS and then analyzed by SDS/PAGE, followed by CBB staining and autoradiography. Lanes 1 and 4 , GST; lanes 2 and 5, GST–NK; l anes 3 and 6, GST– RS. The arrowhead and double arrowhead ... preliminary results s uggested t hat an in vitro assay system f or the a nalysis of t he cell c ycle-dependent interaction of LBR and chromatin can be developed using this bind...

Ngày tải lên: 22/02/2014, 04:20

... significantly altered by the transcriptional status of DNA. In contrast to loxP sites and sites I of res, the reactivity of episomal and genomic full length res differed markedly in our analysis. Genomic ... outlined above by employing two site- specific recombination systems that differ markedly in their complexity. The less elaborate system is represented by the Cre recombinase encoded b...

Ngày tải lên: 22/02/2014, 07:20

... were hydrophobic in char- acter and very similar in terms of both shape and dimension. They were mainly bounded by helix H10 of a-tubulin and by helix H6 and the H6–H7 loop of b-tubulin. By adopting ... arrest and, ultimately, cell death by apoptosis [11]. The taxane binding site on tubulin was experimen- tally determined approximately 10 years ago [1,12–14]. Keywords conformatio...

Ngày tải lên: 16/03/2014, 01:20

... annexin II by matrilysin may result from the specific binding of matrilysin to the cancer cells. In our previous study, among three MMPs tested (matrilysin, MMP-2 and MMP-3), only matrily- sin was ... annexin II and converted it to the 35 kDa form (Fig. 2). This cleavage was inhibited by an MMP inhibitor, N-(R)-[2-(hydrox- yaminocarbonyl)-methyl]-4-methylpentanoyl-l-naphthyl- alanyl-l-al...

Ngày tải lên: 17/03/2014, 17:20