Báo cáo y học: "High resolution discovery and confirmation of copy number variants in 90 Yoruba Nigerians" pdf

... examined known copy number variants in 10 Yoruba using Agilent microarrays; and in the Wang et al. [15] study, 36 Yoruba were genotyped using Illumina BeadChips. For each Yoruba individual in common ... CNVs, and type large numbers of individuals in order to gain biological insights beyond the initial discovery. Materials and methods Array synthesis Arrays were s...

Ngày tải lên: 09/08/2014, 20:20

... into catalysis and inhibition of O-acetylserine sulfhydrylase from Mycobacterium tuber- culosis: crystal structures of the enzyme-a-aminoacrylate intermediate and an enzyme–inhibitor complex. ... stability of the protein. Consequently, the Fig. 4. Stereoview of a superposition of five distinct CysM chain folds showing wild-type CysM in blue [6], CysM(RKE) subunit A in green,...

Ngày tải lên: 07/03/2014, 05:20

... stenosis. Consent Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor -in- Chief of ... angiography 2008: dynamic infundibular pul-monary artery stenosis during blood flow ejectionFigure 4 Right ventricular angiography 2008: dynamic infundibular pulmon...

Ngày tải lên: 10/08/2014, 10:20

... significantly less abundant in the RNA, being involved in 61% of all decre asing DNA-RNA amino acid frequency changes. In contrast, frequency increases were dominated by amino acids enriched in GC: 50% of increases ... richness in expressed genes is potentially driven by a combination of factors, including selection against metabolically costly amino acids (for example, AT-enr...

Ngày tải lên: 09/08/2014, 22:24

... therapy using siRNA targeting Bcl-xL and cisplatin against prostate cancer. Int. J. Cancer 2009;125(12):2978 -90 41. Cherry J, Karschner V, Jones H, and Pekala PH. HuR, an RNA-binding protein, involved ... toxicity and poor response [19]. Despite initially encouraging results of tumor growth control were reported in other tumor types than brain tumors [20], the results of a...

Ngày tải lên: 26/10/2012, 09:48

... C. elegans, in particu- lar in the analysis of splicing and RNA stability. Materials and methods Strain maintenance and RNA preparation and processing C. elegans strains were maintained on NGM ... particular, many PTCs are introduced by splicing errors [29,31,32,40,49,50], including intron retention and the incorrect retention or skipping of exons, and we examined these i...

Ngày tải lên: 09/08/2014, 20:20

... 4a) and the correspond- ing histology (Fig. 4b) of severely diseased cartilage. Dis- tinctive thinning of the cartilage was observed only on the left portion of both OCT image and histology. In ... described in detail pre- viously [9,10]. A schematic drawing of the OCT system used in this study is shown in Fig. 1a. In this study, a novel, compact, handheld OCT imaging pr...

Ngày tải lên: 09/08/2014, 06:22

... transcription of intergenic regions and the antis ense strands of hundreds of annotated protein-cod- ing genes occurs in budding yeast, despite it lacking ves- tiges of the protein machinery required ... show signs of phase-specific splicing; hence, in contrast to meiosis in budding and fission yeast [49,50], we see no evidence for a regulatory role of splicing in the...

Ngày tải lên: 09/08/2014, 20:21

... detection of runs of homozygous and heterozygous genotypes; 2) joining of neighbouring homozygous segments across regions of low SNP d ensity; 3) modeling of detected homozygous and heterozygous ... frequency of homozygous segments with haplotypes underlying ext AUC peaks. Analysis of the consistency of the homozygous extent distribution and length and frequency of h...

Ngày tải lên: 09/08/2014, 22:23

... microarray experiments, data analysis, and writing; NL, VG, SV, VN, MY, and RS, data analysis; MZ, data analysis and writing; JM and JL, MS typing; KH and TEW, genetic cross and writing; BH, ... Many factors can influ- ence estimates of RR (or more precisely outcrossing rate), including the intensity of transmission by mosqui- toes, diversity o f local parasite populations, th...

Ngày tải lên: 09/08/2014, 22:24