Báo cáo y học: " Divergence of exonic splicing elements after gene duplication and the impact on gene structures" pot

... enhancers and silencers after gene duplication and the contributions of such divergence to the generation of new splicing isoforms. We found that exonic splicing enhancers and exonic splicing ... creation and disruption could be caused by nonsynonymous changes (Table 3). However, these non- synonymous changes may be slightly deleterious and the pri- mary...

Ngày tải lên: 09/08/2014, 20:20

... correct timing of removal of the cast [1]. The numerous technical components requiring proficiency for the success of the technique may explain the reported variation and the reliability issues of casts ... completed by Payne [16], as the cost of digital technology has significantly decreased over the past 5 years. Limitations The main limitation of this study...

Ngày tải lên: 10/08/2014, 21:24

... their position with the gene, and so on. They also described a novel unbiased protocol for amplification and labeling of full-length RNAs, combining random-primed first-strand and second-strand synthesis ... a cDNA spotted array to demonstrate successful detection of experimentally induced intron reten- tion in a number of genes containing introns. Yeakley et al. [22] detected...

Ngày tải lên: 09/08/2014, 20:20

... recurrence, adjuvant therapies such as radia- tion therapy or chemotherapy might be necessary after RT. Those therapies could also affect the fertility and the pregnancy course of the patient. However, ... arteries and vaginal arteries affect the function of the neo-cervix? Lack of mechanical support of the residual cer- vix, ascending infection and chorioamnoni...

Ngày tải lên: 25/10/2012, 11:48

... optimal reconstruction of soft tissues and to assure the preservation of the bone graft from epithelial connection. Conclusions: This surgical procedure showed a good stability of the bone grafts, ... inflammation and thickening of the mucosal lining of the sinus in areas adjacent to the involved teeth 4 . This inflammation may be a consequence of overinstrum...

Ngày tải lên: 25/10/2012, 11:48

... 6 , Yin Chyi Chan 1 and So Har Ton 1 1. School of Arts and Sciences, Monash University Malaysia, Petaling Jaya 46150, Malaysia 2. Faculty of Biotechnology, Malaysia University of Science and ... subtypes Ba and Bj as another variable to look at in the correlation analysis between genotypes and core promoter mutations. The varying proportions of the Ba and Bj s...

Ngày tải lên: 02/11/2012, 10:14

... to further explore the biochemical function of group I allergens. Expression of glycosylated and nonglycosylated rPhl p 1 reveals differing stability of these allergens The expression of rPhl ... numbered. Areas of high similarity exist around Cys69 and Cys72 and around Trp186, Trp193 and Trp197. The positions of Cys41, 57, 69 and 72 are especially conserved betwee...

Ngày tải lên: 08/03/2014, 22:20

... biosyn- thetic pathways of tetrahydrofolate and tetrahydrobiopterin [3,4]. GTP cyclohydrolase II catalyzes the hydrolytic release of C8 of GTP accompanied by the release of pyrophosphate from the ... is initiated by the hydrolytic release of pyrophosphate, possibly involving the formation of a covalent phosphoguanosyl derivative of the enzyme. Carbon 8 of the g...

Ngày tải lên: 23/03/2014, 21:20

... specific activity of 74 TBqÆmmol )1 . Binding and cAMP assay For the determination of the binding affinity and the biological potency of the photoactivatable CRF antagonists, HEK 293 cell lines, stably transfected ... between the N and C terminus of the CRF 1 receptor and its ligand, respectively. The N-terminal phenylalanine/histidine and phenyldiazirine/ histid...

Ngày tải lên: 31/03/2014, 08:20

... methyl ester had only a minor effect on the toxicity of the protein. Addition of microglia had no signifi- cant effect on the toxicity of PrP121– 231. These results suggest that the toxicity of ... to the very hydrophobic nature of this region, this may occurs directly after cleavage of the protein. Our studies of toxicity used wild-type neurones and neurones...

Ngày tải lên: 31/03/2014, 23:20