Báo cáo y học: "An optimization framework for unsupervised identification of rare copy number variation from SNP array data " doc

... regression model for raw copy number estimation of both SNP and CN markers. Figure 7a gives an example of raw copy numbers for a 394-marker region. Algorithm for copy number variant detection Key to our ... segments of con- sistent copy number. The Affymetrix SNP array was originally designed so that each SNP is interrogated by 24 to 40 unique probes. Of th...

Ngày tải lên: 09/08/2014, 20:20

... recent analysis showed that life expectancy at age 20 years had increased by over 13 years since the introduction of combination antiretro- viral therapy and currently life expectancy of HIV patients at ... levels of accuracy in this type of analysis are likely to be dependent on the time periods between VL measure- ments, which are typically every six months in patients with HIV. The...

Ngày tải lên: 10/08/2014, 05:21

... conflicts of interest. Author details 1 Department of Cardiovascular and Thoracic Surgery, University of Thessaly, Larissa, Greece. 2 Department of Anesthesiology, University of Thessaly, Larissa, ... solution for the treatment of ascending aortic aneurysms: the wrapping technique. Journal of Cardiothoracic Surgery 2010 5:100. Submit your next manuscript to BioMed Central and...

Ngày tải lên: 10/08/2014, 09:22

... they can easily be ported to any language or domain for which appropriate training data can be found. However, many data- driven systems require careful tuning in order to achieve optimal performance, ... following characteristics of the data set: 1. Number of words/sentences. 2. Existence of “covered roots” (arcs spanning tokens with HEAD = 0). 3. Frequency of labels used f...

Ngày tải lên: 08/03/2014, 21:20

... a structure factor in a data set of n crystals, with p being the individual (one-off) probability of observing data of IQ 7 o r better by chan ce alone. A redundancy of 5 .6 in this data set corresponds ... accuracy of both amplitude and phase components. Amplitudes are generally noisier for cryo-electron microscopy, whilst phases are usually more reliable when compared to X...

Ngày tải lên: 17/03/2014, 17:20

... expression levels from small RNA sequencing performed by Kato et al. [43]. Data sets for other organisms In yeast, the expression levels of genes were measured by microarrays and available from Wang ... genome-wide datasets. * Correspondence: mark.gerstein@yale.edu 1 Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, CT 06520, USA...

Ngày tải lên: 09/08/2014, 22:23

... USA. 5 Department of Genetics, Stanford University School of Medicine, Alway M344, Stanford, CA 94305, USA. 6 Program in Computational Biology and Bioinformatics, Yale University, 266 Whitney Ave, New ... flexibility and intuitiveness to allow for the formal definition of these types of relation- ships. In the remainder of the text, we describe CRIT and apply it to three different...

Ngày tải lên: 09/08/2014, 22:24

... period of pain relief being 5 months. The range of relief for the radiofrequency group was from zero days to 16 months for all 26 patients who underwent the radiofrequency procedure. Of the ... limited or no follow-up data 7 12 15 11 . Cryorhizotomy is reported in to be of similar ef- ficacy. In a study of 76 patients treated via CT-guided cryorhizotomy of the...

Ngày tải lên: 26/10/2012, 09:32

... 6(4):224-226 © Ivyspring International Publisher. All rights reserved Research Paper Endoscopic thoracic laminoforaminoplasty for the treatment of thoracic radiculopathy: report of 12 cases Scott ... Conclusions: Endoscopic laminoforaminoplasty offers an alternative to fusion or conven- tional laminotomy with similar success rates. Patients additionally benefit from a decrease...

Ngày tải lên: 26/10/2012, 09:57

... obtained for the Kolmo- gorov-Smirnov test (study of normality of continuous variables) are shown in Table 3. Table 3. Normality Analysis of the Continuous Variables. Kolmogorov-Smirnov test for ... moment of the construction of the data package. The funda- mental cause was the lack of fulfilment of the inclu- sion criteria. The assembly of the previous data packag...

Ngày tải lên: 03/11/2012, 11:34