Báo cáo y học: "Simultaneous transcription of duplicated var2csa gene copies in individual Plasmodium falciparum parasites" potx

... reproduction in any medium, provided the original work is properly cited. Plasmodium duplicate gene expression<p> ;Duplicated var2csa genes in one strain of Plasmodium falciparum are simultaneously ... between highly similar gene copies in P. falciparum parasites. The duplicated var2csa variants are simultaneously transcribed, both on a population level and i...

Ngày tải lên: 09/08/2014, 20:20

... loss of nuclear transcription factors binding to two distinct regulatory motifs in the promoter region of the CD28 gene [14]. The repression of CD28 transcription may be also the consequence of ... amount of IFN in the absence of costimulatory pathway [10,13]. The expansion of this cell population is genetically determined. CD28 deficiency is due to a transcriptional b...

Ngày tải lên: 09/08/2014, 01:22

... pathways. A previous study reported that circadian rhythms of clock genes including mPer1 were maintained in the kidneys of SCN-lesioned mice [28]. In feeding studies, it was found that feeding schedules ... entrain the circadian rhythm of clock gene expression in the liver independent of the SCN [29,30]. These findings suggest that the circadian rhythms of peripheral organs...

Ngày tải lên: 10/08/2014, 09:20

... limitation of video recording during darkness by using a camera that, by automatically switch- ing to infrared in complete darkness, allowed us to contin- uously monitor activity during the light ... methods in general either present flaws or are of very high cost. For example, counting interruptions of infrared light beams in a cage using photocell sensor units mainly reflects lo...

Ngày tải lên: 10/08/2014, 09:20

... report A 54-year-old male presented in the Emergency Department of our Institution, complaining of pain, deformity of the left wrist and elbow and inability to move these joints, following a fall ... during the last 30 years [8]. A simultaneous dislocation of the radial head and distal radio-ulnar joint with no other injury seems to be extremely rare since only one report was...

Ngày tải lên: 08/08/2014, 17:20

... overall memory footprint when running several instances of GenomeMapper in parallel. Index graph creation The input for GenomeMapper's index-creation step consists of the sequence of one of the ... (repre- sented by 3 bytes) and the position within the block (1 byte). Based on this information, the position of every base within each of the genomes can be inferred. The 4-byt...

Ngày tải lên: 09/08/2014, 20:20

... change that results in bypassing a proofreading mechanism of the Sec machinery [25]. The energy for precursor translocation is supplied by the hydrolysis of ATP by SecA and by the proton-motive ... mutation in secY reduced the pmf dependency of protein translocation [21]. Similarly, a single amino-acid substitution, replacing the helix-breaking glycine at position )10 in the hydro...

Ngày tải lên: 08/03/2014, 09:20

... Tyr. These mutations may in uence the shape and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme for PAA and derivatives thereof, while maintaining the ... property of bF24A is its increased esterase/ amidase ratio. In general the enzyme-catalysed hydrolysis of esters is faster than the hydrolysis of the corresponding amides due to th...

Ngày tải lên: 17/03/2014, 23:20

... serine residues carrying O-linked glycan chains and distributed in tandemly repeated motifs in the central part of the protein backbone. Mucins are known to play important roles in the lubrication ... composed of a large mucin-type domain characterized by the perfect repetition of 16 amino-acid residues. Like other mucins, this mucin-type domain exhibits a variable number of tan...

Ngày tải lên: 17/03/2014, 23:20

... treatment of ADHD [24-26]. In some cases, IR preparations are slowly titrated by weekly increments of 5-10 mg/day according to tolerability and the degree of efficacy observed, up to a maximum daily ... core symptoms of inattention, hyperactivity and impulsivity, patients often exhibit learning difficulties and impairment in social functioning. The frequency of referral is...

Ngày tải lên: 09/08/2014, 01:21