Báo cáo y học: "Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network" pps

... Satisfactory results have not yet been obtained in therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndrome (APS). We therefore compared single antiplatelet therapy ... therapy and a combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with AP...

Ngày tải lên: 26/10/2012, 09:48

... Division of Rheumatology and Immunology, Stanford University School of Medicine, Stanford, California, USA 2 Department of Neurology and Neurological Sciences, Stanford University School of Medicine, ... believe the specificity of the autoantibody response is predictive of the speci- ficity of the overall autoimmune response at the level of whole autoantigens....

Ngày tải lên: 09/08/2014, 06:22

... same joint in both hands) were affected. Our findings suggest that there may indeed be a relationship between the VDR ApaI and TaqI polymorphisms and the risk of symmetrical hand OA in Finnish ... subset of hand OA in women [28,35-37], with three major determinants of the pattern of polyarticular involve- ment being symmetry, clustering by row, and clustering by ra...

Ngày tải lên: 09/08/2014, 07:20

... article Psychological pain treatment in fibromyalgia syndrome: efficacy of operant behavioural and cognitive behavioural treatments Kati Thieme 1 , Herta Flor 1 and Dennis C Turk 2 1 Department of ... The treatment also included time- contingent intake and reduction of medication, increase of bodily activity, reduction of interference of pain with ac...

Ngày tải lên: 09/08/2014, 08:22

... detailed analysis of similar disease pathways operating during early, intermediate and late stages of the development of human arthritis, although they will not be identical to those of RA. On the other ... B cells with the antibody rituximab acting via Review Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of art...

Ngày tải lên: 09/08/2014, 08:23

... followed 238 patients with RA of less than 4 years in dura- tion longitudinally with comprehensive assessments of clinical and radiographic data at baseline and after 5 and 10 years [15]. The patients ... 3 Research article The association between disease activity and NT-proBNP in 238 patients with rheumatoid arthritis: a 10-year longitudinal st...

Ngày tải lên: 09/08/2014, 10:23

... properties by inhibiting the 5-lipoxygenase enzyme. A 90-day, double- blind, randomized, placebo- controlled study was conducted to evaluate the efficacy and safety of 5-Loxin đ in the treatment of osteoarthritis ... not for citation purposes) Vol 10 No 4 Research article A double blind, randomized, placebo controlled study of the efficacy a...

Ngày tải lên: 09/08/2014, 10:23

... variables would have underestimated Table 4 Relationship between adiposity measures and risk of primary knee and hip replacement Primary knee replacement (n = 541) Primary hip replacement (n = 468) ... associated risks between the adiposity measures and knee and hip joint replacement, all adiposity measures were stronger risk factors f...

Ngày tải lên: 09/08/2014, 13:22

... prioritizing candidate disease genes and quantifying the disease- disease associationsFigure 1 Construction of an integrated functional linkage network (FLN) with applications in prioritizing candidate disease ... experiments, and functional associations mapped from yeast, worm, and fly (organisms distant to human in the evolutionary tree). Predictions from th...

Ngày tải lên: 09/08/2014, 20:20

... Access ExpressionPlot: a web-based framework for analysis of RNA-Seq and microarray gene expression data Brad A Friedman 1,2,3* and Tom Maniatis 4 Abstract RNA-Seq and microarray platforms have ... ExpressionPlot: a web-based framework for analysis of RNA-Seq and microarray gene expression data Friedman and Maniatis Friedman and Maniat...

Ngày tải lên: 09/08/2014, 23:20

... Access Research Eukaryotic large nucleo-cytoplasmic DNA viruses: Clusters of orthologous genes and reconstruction of viral genome evolution Natalya Yutin 1 , Yuri I Wolf 1 , Didier Raoult 2 and Eugene ... evolution- ary analysis of new NCLDV genomes. We also report some patterns of evolution of the NCLDV that can be inferred from a preliminary analysis of...

Ngày tải lên: 12/08/2014, 04:21

... pulmonary mechan- ics, the young ASCFTR adults enjoyed periods of relative structural normality and morphometric analysis of young adults did not show any differences in the volume densi- ties of ... transeint disruption of stretch-induced organogenesis can result in progress lung disease due to disruption of organogenesis. Interestingly, some aspects of CF pathology may...

Ngày tải lên: 12/08/2014, 14:20

... day is also associated with an approximately 10–50 ml increase in FEV 1 [5]. Commentary Chronic obstructive pulmonary disease, asthma and protective effects of food intake: from hypothesis to ... dietary intake and respiratory disease. Nutrients, foods or a healthy diet? The effects of diet may be due to specific nutrients, to specific foods or to a ‘he...

Ngày tải lên: 12/08/2014, 18:20

... boost HIV-1 spread in HIV-1- infected HLAC and identify two inde- pendent protein interaction motifs in Nef that facilitate CD4 + T lymphocyte depletion independently of their effect on HIV-1 replication. Nef ... predominately in uninfected bystander CD4 + T cells. Conclusion: Our findings suggest that Nef facilitates depletion of CD4 + T lymphocytes in...

Ngày tải lên: 13/08/2014, 05:21

... preferred to severity of disease as the main guiding principle in priority setting in resource poor settings? The case of Uganda Lydia Kapiriri* 1 , Trude Arnesen 2 and Ole Frithjof Norheim 1 Address: ... and severity of disease as criteria for priority setting in health have shown a strong preference for severity of disease. These pref...

Ngày tải lên: 13/08/2014, 13:20