Báo cáo y học: ":New tricks for an old-favorite model" pps
Báo cáo y học: ":New tricks for an old-favorite model" pps
... related to systems and synthetic biology, yeasts as model organisms in gene expression, aging and human disease studies and the use of yeast cells as factories.Yeast as model organism for aging ... larval and adult body sizes. TOR is linked to aging from yeast to mammals and deregulation of the pathway causes disease in humans (such as cancer, cardiac hypertrophy and inflammatory diseases). ... before transcripts are delivered to processing bodies, and it interacts with target transcripts at or soon after their trans-cription. Microarray analysis for cells grown in low iron supply...
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Báo cáo y học: "New hope for haplotype mapping" pptx
... technology,without it being necessary to type every DNA variant indi-vidually in an attempt to identify the functional polymor-phism responsible for a disease.Until recently, only a few studies ... haplo-types that, on average, are 11 kb in length in Nigerian andAfro-American samples, and are 22 kb in length in Euro-pean and Asian samples. These haplotypes could be iden-tified by as few ... results? By defining haplotypes veryrigorously, one will find many short stretches of virtuallycomplete LD in the genome. A less stringent approachcan establish the presence of longer ancestral...
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Báo cáo y học: "No evidence for an association between the -871 T/C promoter polymorphism in the B-cell-activating factor gene and primary Sjögren''''s syndrome" pptx
... factor levels wasanalyzed using analysis of variance. Statistical analysis wasperformed using Analyse-it for Microsoft Excel (Leeds, Eng-land, UK).ResultsThe allelic and genotypic distribution ... (T allele frequency in patients without autoan-tibody: 45%; in patients positive for anti-SSA autoantibodyonly: 48%; in patients positive for anti-SSA + anti-SSBautoantibody: 52%; P = 0.76). ... ValueAge (mean ± SD) 57.3 ± 12.1Women/men (n)156/6No anti-SSA or anti-SSB autoantibodies (n [%]) 52 (32)Anti-SSA autoantibody only (n [%]) 54 (33.4)Anti-SSA and anti-SSB autoantibodies (n...
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Báo cáo y học: "Gene profiling for defining targets for new therapeutics in autoimmune diseases" potx
... The possibility to measure levelsof gene expression for tens of thousands of genes simultaneously and in a quantitative fashion willgreatly enhance our knowledge of genes and pathways involved ... expression in humans will require manyreplicate experiments and/or an extensive characteriza-tion of normal variability.To exert their functions, type 1 and type 2 T lymphocyteshave to home ... mouseCD4+and CD8+T cells with anti-CD3/CD28 antibodies,IL-2 and IL-6 plus the polarizing cytokine cocktail. Cellswere cultured for 7 days and then restimulated for 24 hours with anti-CD3 before...
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Báo cáo y học: "New insights into integrin signalling: implications for rheumatoid arthritis synovial fibroblasts" pptx
... M,Okada M, Tanaka Y, Koshihara Y, Oda H, Kurokawa T, NakamuraK, Tanaka S: Suppression of arthritic bone destruction by ade-novirus-mediated csk gene transfer to synoviocytes andosteoclasts. ... integrin-stimulated FAKautophosphorylation and cytoskeletal rearrangement in cellspreading and migration. J Cell Biol 2003, 160:137-146.5. Su J, Muranjan M, Sap J: Receptor protein tyrosine phos-phatase ... Zeng and coworkers [4] address only part ofthe several pathways that have been linked to Src and FAKsignalling and that are of interest for enhancing our under-standing the complex nature of activated...
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Báo cáo y học: "Rheumatoid arthritis is an independent risk factor for multi-vessel coronary artery disease: a case control study" pdf
... mg/dl and/or treated by a physician for hypercho-lesterolemia, hypertension under treatment, smoking history(yes or no), and type I or type II diabetes. We have selectedvariables in our analysis ... etiology [11]. RA is characterized bychronic inflammation and hyperplasia of synovial tissue. Moreimportantly, it is a quintessential systemic disease that canmanifest in most major organ systems ... Kopecky SL, Frye RL,Goronzy JJ, Weyand CM: T-cell-mediated lysis of endothelialcells in acute coronary syndromes. Circulation 2002,105:570-575.11. Martens PB, Goronzy JJ, Schaid D, Weyand CM:...
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Báo cáo y học: "Cost-utility of an 8-month aquatic training for women with fibromyalgia: a randomized controlled trial" ppt
... conception, planning and design of thestudy, as well as the acquisition, analysis, and interpretation ofdata, and writing of the manuscript. PTC was involved in theacquisition of data, analysis and ... adjusted by regressionanalysis for differences in baseline EQ-5D scores [21].Cost utility analysisFirst, we estimated the incremental mean costs of the water-based programme and the mean QALYs added ... of man-uscript. Both authors read and approved the final manuscript.AcknowledgementsThanks to Yolanda Garcia for her technical support as research assist-ant. The study was supported by the...
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Báo cáo y học: "Study protocol for the translating research in elder care (TREC): building context – an organizational monitoring program in long-term care project (project one)" ppsx
... place.Data analysisData analysis is an ongoing iterative process. Data arecleaned and processed for analyses at the close of eachquarter. Real-time descriptive analyses are completedmore frequently ... inthe LTC setting yielded satisfactory results). In brief, wewill conduct reliability (internal consistency) and validity(factor analysis, item analysis, and modeling) analyses.We will examine ... Saskatoon, Saskatchewan, Canada, 3School of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada and 4Faculty of Medicine, University of Calgary, Calgary, Alberta, CanadaEmail:...
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Báo cáo y học: "IMP321 (sLAG-3), an immunopotentiator for T cell responses against a HBsAg antigen in healthy adults: a single blind randomised controlled phase I study" ppt
... arbitraryvalue of 1 mIU/mL for GMT calculation.Data analysisThe analyses for safety and tolerability parameters wereperformed on all randomised subjects who received atleast one dose of study ... Laboratory testsincluded a complete blood count, serum chemistry, liverand renal function, and coagulation measures. Rheuma-toid factors, anti-nuclear antibody titres (ANA) and anti-IMP321 antibodies ... A very large number of PBMCswere analysed (as an average 0.9 × 106 cells) by flowcytometry to secure the validity of small percentages and/or differences. Results following FACS analysis...
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Báo cáo y học: "Endoscopic therapy using an endoscopic variceal ligation for minute cancer of the esophagogastric junction complicated with esophageal varices: a case report" ppt
... final manuscript.Author Details1Gastroenterology Division, Yokohama City University School of Medicine, Japan and 2Department of Pathology, Yokohama City University Hospital, JapanReferences1. ... technical simplicity andsafety, endoscopic therapy using an EVL device for min-ute cancer of the EGJ, complicated with esophagealvarices, may be an acceptable and easily applicablemethod.ConsentWritten ... ultrasonography.Competing interestsThe authors declare that they have no competing interests.Authors' contributionsTA, YA, HT and KY analyzed and interpreted our patient data. HI, HE and KH ana-lyzed...
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