Báo cáo y học: ":New tricks for an old-favorite model" pps

... related to systems and synthetic biology, yeasts as model organisms in gene expression, aging and human disease studies and the use of yeast cells as factories. Yeast as model organism for aging ... larval and adult body sizes. TOR is linked to aging from yeast to mammals and deregulation of the pathway causes disease in humans (such as cancer, cardiac hypertrophy and inflammatory dise...

Ngày tải lên: 09/08/2014, 20:20

... technology, without it being necessary to type every DNA variant indi- vidually in an attempt to identify the functional polymor- phism responsible for a disease. Until recently, only a few studies ... haplo- types that, on average, are 11 kb in length in Nigerian and Afro-American samples, and are 22 kb in length in Euro- pean and Asian samples. These haplotypes could be iden- tified by...

Ngày tải lên: 09/08/2014, 01:21

... factor levels was analyzed using analysis of variance. Statistical analysis was performed using Analyse-it for Microsoft Excel (Leeds, Eng- land, UK). Results The allelic and genotypic distribution ... (T allele frequency in patients without autoan- tibody: 45%; in patients positive for anti-SSA autoantibody only: 48%; in patients positive for anti-SSA + anti-SSB autoantibody: 52%; P =...

Ngày tải lên: 09/08/2014, 07:20

... The possibility to measure levels of gene expression for tens of thousands of genes simultaneously and in a quantitative fashion will greatly enhance our knowledge of genes and pathways involved ... expression in humans will require many replicate experiments and/or an extensive characteriza- tion of normal variability. To exert their functions, type 1 and type 2 T lymphocytes have to hom...

Ngày tải lên: 09/08/2014, 01:21

... M, Okada M, Tanaka Y, Koshihara Y, Oda H, Kurokawa T, Nakamura K, Tanaka S: Suppression of arthritic bone destruction by ade- novirus-mediated csk gene transfer to synoviocytes and osteoclasts. ... integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration. J Cell Biol 2003, 160:137-146. 5. Su J, Muranjan M, Sap J: Receptor protein tyrosine ph...

Ngày tải lên: 09/08/2014, 01:22

... mg/dl and/or treated by a physician for hypercho- lesterolemia, hypertension under treatment, smoking history (yes or no), and type I or type II diabetes. We have selected variables in our analysis ... etiology [11]. RA is characterized by chronic inflammation and hyperplasia of synovial tissue. More importantly, it is a quintessential systemic disease that can manifest in most major organ...

Ngày tải lên: 09/08/2014, 06:23

... conception, planning and design of the study, as well as the acquisition, analysis, and interpretation of data, and writing of the manuscript. PTC was involved in the acquisition of data, analysis and ... adjusted by regression analysis for differences in baseline EQ-5D scores [21]. Cost utility analysis First, we estimated the incremental mean costs of the water- based programme and the me...

Ngày tải lên: 09/08/2014, 10:23

... place. Data analysis Data analysis is an ongoing iterative process. Data are cleaned and processed for analyses at the close of each quarter. Real-time descriptive analyses are completed more frequently ... in the LTC setting yielded satisfactory results). In brief, we will conduct reliability (internal consistency) and validity (factor analysis, item analysis, and modeling) analyses. We...

Ngày tải lên: 11/08/2014, 05:21

... arbitrary value of 1 mIU/mL for GMT calculation. Data analysis The analyses for safety and tolerability parameters were performed on all randomised subjects who received at least one dose of study ... Laboratory tests included a complete blood count, serum chemistry, liver and renal function, and coagulation measures. Rheuma- toid factors, anti-nuclear antibody titres (ANA) and anti- IMP3...

Ngày tải lên: 11/08/2014, 10:23

... final manuscript. Author Details 1 Gastroenterology Division, Yokohama City University School of Medicine, Japan and 2 Department of Pathology, Yokohama City University Hospital, Japan References 1. ... technical simplicity and safety, endoscopic therapy using an EVL device for min- ute cancer of the EGJ, complicated with esophageal varices, may be an acceptable and easily applicable...

Ngày tải lên: 11/08/2014, 12:20