Báo cáo y học: "Predicting drug side-effects by chemical systems biology" pptx

... intubation by anaesthesiologists in patients with severe trauma: an audit of a Norwegian helicopter emergency medical service. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine ... 18:30 http://www.sjtrem.com/content/18/1/30 Page 4 of 6 ORIGINAL RESEARCH Open Access Pre-hospital intubation by anaesthesiologists in patients w...

Ngày tải lên: 25/10/2012, 09:56

... muscle layers. The vasa recta, which supply the mucosa and submucosa of the colon, penetrate the circular muscle. The weakness of the vascular portals in the circular muscle possibly causes ... copy owing to incomplete bowel preparation. The bleeding was controlled by #3-0 Vycryl intracorporeal suture, and the invagination of the diverticulum was performed...

Ngày tải lên: 25/10/2012, 10:51

... cycle arrest and to play an important role in cancer prevention. Genistein, daidzein and isoflavonoids in soybean are thought to play an important role in breast cancer prevention [1]. In addition, ... 35.4 Events Events Events Events Events Events Events Events Events PI-Area (control) PI-Area (control) PI-Area (control) PI-Area (5%) PI-Area (5%) PI-Area (10%) PI-Area (10%) PI-Area...

Ngày tải lên: 02/11/2012, 11:12

... was checked by 1 HNMR and HPLC. Spectrophotometric determination of laccase activity The activity of laccase was determined by following the rate of oxidation of 2,2Â-azinobis-(3-ethylbenzothiazoline-6- sulfonate) ... the results of our laccase oxidations of substrates 1–5, and the effect of the cosolvent and of the mediators on the amount of substrate meta...

Ngày tải lên: 21/02/2014, 01:21

... Family history of polycythemia in a subject with polycythemia should raise the suspicion for the presence of a high affinity Hb variant [14]. A low P50 value (obtained from venous gas parameters) ... and in turn, can change the affinity of Hb for oxygen. The majority of mutations affecting oxygen affinity result in high affinity Hb variants which result...

Ngày tải lên: 08/08/2014, 16:23

... interviewer administered the MADRS. A few days later the MADRS was administered again, but now by telephone and by a different interviewer. The validity of the telephone rating was calculated through the ... not for citation purposes) Annals of General Psychiatry Open Access Primary research Administering the MADRS by telephone or face-to-face: a vali...

Ngày tải lên: 08/08/2014, 21:20

... as: Kozma et al., Predicting hospital admission and dis- charge with symptom or function scores in patients with schizophrenia: pooled analysis of a clinical trial extension Annals of General ... cited. Primary research Predicting hospital admission and discharge with symptom or function scores in patients with schizophrenia: po...

Ngày tải lên: 08/08/2014, 23:21

... path- ways involved in cytokine/chemokine activity (cytokine- cytokine receptor interaction and Jak-STAT signalling), matrix remodelling (focal adhesion, TGF-β signalling, and ECM receptor interaction), ... inhibi- tion prevents proinflammatory cytokine-induced cartilage damage. Rheumatology (Oxford) 2002, 41:801-808. 12. Tak PP: Chemokine inhibition in inflammatory arthritis. Best Prac...

Ngày tải lên: 09/08/2014, 01:22

... K: Elevation of interleukin-8 (IL-8) levels in joint fluids of patients with rheumatoid arthritis and the induction by IL-8 of leuko- cyte infiltration and synovitis in rabbit joints. Lymphokine Cytokine ... separately with cell-permeable inhibitors of MAP kinase/ERK kinase-1/2 (PD98059), p38 (SB203580), protein kinase C (calphostin C), and tyrosine kinase (genistein),...

Ngày tải lên: 09/08/2014, 01:22

... pathogenesis of RA. The principal plasma inhibitor of thrombin is antithrombin, a single-chain 51 kDa glycoprotein that is synthesized in liver. The inhibitory activity of antithrombin on thrombin is ... presence of HA, supporting the notion that HA could compete with heparin for the heparin-binding region of antithrombin. Remarkably, HA affected the inhibition b...

Ngày tải lên: 09/08/2014, 06:22

... cells and lymphocytes. Indeed, CXCL12 is constitutively displayed by endothelial cells (ECs) in the bone marrow and secondary lymphoid organs, where it seems to be produced by nearby osteoblasts, ... SDF-1) is constitutively expressed by stromal resident cells and is involved in the homeostatic and inflammatory traffic of leukocytes. Binding of CXCL12 to glycosaminoglyca...

Ngày tải lên: 09/08/2014, 07:20

... and in vivo studies showed that methotrexate is ineffective in the presence of antagonists of adenosine or adenosine deaminase (the enzyme responsible for the deamination of adenosine to inos- ine) ... the anti-inflammatory effects of methotrexate and adenosine are mediated by different receptors in different inflammatory loci, an observation that may explain w...

Ngày tải lên: 09/08/2014, 07:20

... cancer therapy while avoiding drug resistance by targeting multiple tyrosine kinase receptors [6]. Chemical systems biology, or the application of system- wide tools to the analysis of pharmacological ... used a chemical systems biology approach to explain the serious side-effects of a drug that was being trialed for prevention of cardiovascular disease. Systems biology...

Ngày tải lên: 09/08/2014, 20:20

... usually accomplished using DNA arrays, was employed to identify batteries of genes and biological systems that are controlled by the master clock in the SCN [4,9], as well as rhythms regulated by ... research interactions information refereed research Minireview Circadian clocks are seeing the systems biology light Kevin R Hayes, Julie E Baggs and John B Hogenesch Address:...

Ngày tải lên: 14/08/2014, 14:21

... AMPA receptors themselves. Moreover, the NMDA receptor complex is cer- tainly highly dynamic, and may vary in ways not yet fully appreciated. Thus, the definition of a mammalian NMDA receptor complex, ... the presynaptic active zone. Similarly, extensive walks are possible postsynaptically, for example, through PSD-95 to the specialized AMPA gluta- mate receptor subunit, stargazin, and t...

Ngày tải lên: 14/08/2014, 16:21