Báo cáo y học: "Assisted assembly: how to improve a de novo genome assembly by using related species" pptx

... methods Code and assembly We used ARACHNE [14,15] to generate initial draft assem- blies, and all the assisted assembly tools were developed inside the framework provided by ARACHNE. The code is available ... assisted assembly algorithms and the assemblies themselves are available online [9]. Assisted assembly algorithm The assisted assembly process starts by simultaneously bu...

Ngày tải lên: 09/08/2014, 20:20

... surgery but accounts for more than 80% of all postsurgical deaths [23]. Examples typically include frail elderly patients with significant cardiac or respiratory disease who are undergoing major abdominal ... therapies aiming to achieve an oxygen delivery index of 600 ml/min per m 2 wherever possible, without causing tachycardia or myocardial ischaemia. Central venous oxygen saturation has...

Ngày tải lên: 12/08/2014, 20:20

Ngày tải lên: 09/08/2014, 01:21

... fluoropyrimidine antimetabolite. It is converted to 5- FU preferentially in tumor tissue, and also in the liver, by way of a three-step enzymatic cascade [1]. Capecitabine is a relatively new agent, with FDA ... CT and biopsy evidence of steatosis in a few cases [4]. There are, however, no known reports of liver damage caused by oral fluoropyrimidines [5]. Case presentation A 74...

Ngày tải lên: 11/08/2014, 03:20

... sessions. All these assessments are administered by specially trained research assistants. Medical assessments are conducted by a physician or laboratory personnel and include: blood pressure, heart rate, ... criteria Exclusion criteria a. at least 18 years old b. cocaine dependence previous year  c. regular cocaine use in past month ( 8 days) d. cocaine administration primarily...

Ngày tải lên: 11/08/2014, 15:22

... output measured by PiCCO. J Cardiothorac Vasc Anesth 2008, 22:688-692. 14. Yamashita K, Nishiyama T, Yokoyama T, Abe H, Manabe M: E ects of vasodilation on cardiac output measured by PulseCO. ... pulmonary artery catheter.  ese studies suggested that after signifi cant haemodynamic change (vasodilatation), the algorithms may underestimate the cardiac output and therefore not give...

Ngày tải lên: 13/08/2014, 20:22

... strand of this site in the presence of Dnmt1. Kinetically this reaction scheme means that two methyl groups are always introduced, one slowly by Dnmt 3a or by de novo methylation catalyzed by Dnmt1 ... methylation with M.HpaII using radiolabeled AdoMet. No radioactivity was incorporated into the DNA demonstrating that all HpaII sites are fully methylated. RESULTS AND DISCUSSION I...

Ngày tải lên: 21/02/2014, 01:21

... reaction, but the EPR signal developed after the delay. The delayed signal was inhibited by concomitant addition of SOD and the metal chelator DTPA. These data show that initial PBN adducts are dependent ... complexes and thioredoxin-dependent pathways in mitochondria. For instance, they may form an antioxidant defense system, analogous to recently discovered in mycobacteria where the 2-o...

Ngày tải lên: 21/02/2014, 01:21

... high-resolution crystal structures, we have also made a detailed comparison of the binding affinity and inhibitory activity of more than 10 chemically synthesized inhibitor analogues for TM-3. MATERIALS AND ... the TACE structure was solved, adamalysin II had been considered to be a good starting model in SVMP family for the rational design of drugs against TACE-involved inflammatory dise...

Ngày tải lên: 08/03/2014, 23:20

... may still be the only feasible way to assess physical activity in many situa- tions and are important for assessing aspects of physical activity not easily measured objectively, such as mode and ... physical activity every day to keep healthy. However, where children have been inactive, 30 minutes of moderate activity per day is recom- mended and should be built up gradually. A study b...

Ngày tải lên: 13/08/2014, 18:21