Báo cáo y học: "Assisted assembly: how to improve a de novo genome assembly by using related species" pptx

... methodsCode and assembly We used ARACHNE [14,15] to generate initial draft assem-blies, and all the assisted assembly tools were developedinside the framework provided by ARACHNE. The code isavailable ... assisted assembly algorithms and theassemblies themselves are available online [9].Assisted assembly algorithmThe assisted assembly process starts by simultaneously build-ing a de novo assembly ... data set up to twofoldcoverage on high-quality bases (Q20, per-base error rate =1%). With this 2× data set we performed a de novo assembly followed by an assisted assembly against the human...

Báo cáo y học: "Clinical review: How to optimize management of high-risk surgical patients" doc

... surgery but accounts for more than 80% ofall postsurgical deaths [23]. Examples typically include frailelderly patients with significant cardiac or respiratory diseasewho are undergoing major abdominal ... therapies aiming to achieve an oxygen delivery indexof 600 ml/min per m2wherever possible, without causingtachycardia or myocardial ischaemia. Central venous oxygensaturation has been shown ... echocardiography to identifypatients at high risk for perioperative myocardial ischaemia.This process of evaluation may indicate a patient in whom therisks for surgery are not justified by the...

Báo cáo y học: "We are pleased to announce a number of changes to the journal that will take effect from the start of 2003" pdf

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Báo cáo y học: "Hepatic steatosis secondary to capecitabine: a case report" pdf

... fluoropyrimidine antimetabolite.It is converted to 5- FU preferentially in tumor tissue,and also in the liver, by way of a three-step enzymaticcascade [1]. Capecitabine is a relatively new agent, withFDA ... CT and biopsy evidence of steatosis in a fewcases [4]. There are, however, no known reports of liverdamage caused by oral fluoropyrimidines [5].Case presentation A 74-year-old Armenian woman ... diagnosis of capecitabine-induced hepaticsteatosis was made. Capecitabine was held and after onemonth, there was a decline in the transaminases andbilirubin to normal (AST 27 U/L, ALT 35 U/L,...

Báo cáo y học: " Cocaine Addiction Treatments to improve Control and reduce Harm (CATCH): New Pharmacological Treatment Options for Crack-Cocaine Dependence in the Netherlands" doc

... sessions.All these assessments are administered by speciallytrained research assistants.Medical assessments are conducted by a physician orlaboratory personnel and include: blood pressure, heartrate, ... criteria Exclusion criteria a. at least 18 years old b. cocaine dependence previous year  c. regular cocaine use in past month ( 8 days) d. cocaine administration primarily by 'basing' ... in a large-scaleconfirmatory trial. More specifically, we aim to evaluatein three separate randomised controlled, open-label, par-allel-group feasibility trials in crack-cocaine dependentpatients...

Báo cáo y học: "Pulse pressure analysis: to make a long story short" pptx

... output measured by PiCCO. J Cardiothorac Vasc Anesth 2008, 22:688-692.14. Yamashita K, Nishiyama T, Yokoyama T, Abe H, Manabe M: E ects of vasodilation on cardiac output measured by PulseCO. ... pulmonary artery catheter.  ese studies suggested that after signiﬁ cant haemodynamic change (vasodilatation), the algorithms may underestimate the cardiac output and therefore not give a reliable ... pressure to estimate rapid changes in stroke volume in humans. Crit Care Med 2008, 36:3001-3007.13. Yamashita K, Nishiyama T, Yokoyama T, Abe H, Manabe M: The e ects of vasodilation on cardiac...

Tài liệu Báo cáo Y học: Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA pdf

... strand of this sitein the presence of Dnmt1. Kinetically this reaction schememeans that two methyl groups are always introduced, oneslowly by Dnmt 3a or by de novo methylation catalyzed by Dnmt1 ... methylation withM.HpaII using radiolabeled AdoMet. No radioactivity wasincorporated into the DNA demonstrating that all HpaIIsites are fully methylated.RESULTS AND DISCUSSIONIt was the aim ... Finally, it is possible that maintenance methylation atsequences that are not efﬁciently methylated by Dnmt1alone also follows this mechanism.Our data contribute to the view that DNA methylation...

Tài liệu Báo cáo Y học: Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species pptx

... reaction, but the EPR signal developedafter the delay. The delayed signal was inhibited by concomitant addition of SOD and the metal chelatorDTPA. These data show that initial PBN adducts aredependent ... complexes and thioredoxin-dependentpathways in mitochondria. For instance, they may forman antioxidant defense system, analogous to recentlydiscovered in mycobacteria where the 2-oxoglutarate dehy-drogenase ... R,S-Dihydrolipoamide wasobtained from R,S-lipoamide by sodium borohydridereduction as in [47].Enzyme isolation, assays and modiﬁcation2-oxoglutarate and pyruvate dehydrogenase complexesfrom pig heart...

Báo cáo Y học: Determinants of the inhibition of a Taiwan habu venom metalloproteinase by its endogenous inhibitors revealed by X-ray crystallography and synthetic inhibitor analogues pdf

... high-resolution crystalstructures, we have also made a detailed comparison of thebinding afﬁnity and inhibitory activity of more than 10chemically synthesized inhibitor analogues for TM-3.MATERIALS AND ... the TACE structure was solved,adamalysin II had been considered to be a good startingmodel in SVMP family for the rational design of drugsagainst TACE-involved inﬂammatory diseases. Based ... 2002Academia Sinica (Taipei, Taiwan) for assistance in the chemicalsynthesis of inhibitor analogues. We thank Dr Yuch-Cheng Jean of theSynchrotron Radiation Research Center (Hsinchu, Taiwan) and...

Báo cáo y học: "Depression and physical activity in a sample of nigerian adolescents: levels, relationships and predictors" pptx

... may still be theonly feasible way to assess physical activity in many situa-tions and are important for assessing aspects of physicalactivity not easily measured objectively, such as modeand ... physical activity everyday to keep healthy. However, where children have beeninactive, 30 minutes of moderate activity per day is recom-mended and should be built up gradually. A study by Nikapota ... this article as: Adeniyi et al.: Depression and physical activity in a sample of nigerian adolescents: levels, relationships and predictors.Child and Adolescent Psychiatry and Mental Health...

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