Báo cáo y học: "Synorth: exploring the evolution of synteny and long-range regulatory interactions in vertebrate genomes " potx

... species, and that only one of the two copies of the bystander gene is still in synteny with the corresponding copy of the target gene in the fish genome. The code captures the relationship of the bystander ... to the first, a GRB is defined physically by the extent of long-range regulatory elements around its target gene. Therefore, the combined sy...

Ngày tải lên: 09/08/2014, 20:20

... [24]. Non-Hodgkin’s lymphoma Although there was no evidence of any overall increased risk of cancer in the early years of IP and RA in NOAR, there was a definite increased risk of developing non-Hodgkin’s lymphoma ... affect the severity of the disease and genes that affect the handling of the drug. Then there are psychosocial factors such as adherence to and e...

Ngày tải lên: 09/08/2014, 08:22

... out. Because of the focal deficit seen on the brain imaging, involving the left insular and anterior temporal cortex, two brain regions frequently involved in aphasic syndrome but also in FAS, a ... reviewed the manuscript and con- tributed to the writing. NP and LG conducted the brain imaging exams and interpreted the data. All the authors approved the final m...

Ngày tải lên: 08/08/2014, 21:20

... the gastrointestinal tissues from the cytotoxicity of CY in mice. We also profiled the changes of the expression of growth factors in gastric tissues in response to the damage by CY and protection ... protective effect of AP on CY-induced cytotoxicities in both the hemopoietic and gastrointestinal tissues was undefined. Any of these actions would extend...

Ngày tải lên: 02/11/2012, 10:19

... their efficacy in vivo in the treatment of toxoplamosis. To increase the efficacy of therapy a combination of sulfadiazine and pyrimethamine was proposed since synergistic effect of these two ... accepted to introduce a therapy were the following: a) the presence of a lesion within the vascular arcades of the posterior pole (zone 1) b) the presence of a l...

Ngày tải lên: 03/11/2012, 11:01

... erritins. Thus, H c hains predominate in spleen and liver at variance with thepresenceofL chainsinthesameorgansofmammals[6]. Interestingly, a study of cold-inducible gene expression of rainbow ... protein indicated for the N-terminal peptide MDSQVR a value of m/z 777, which points t o the presence of acetylme thionine. This r esidue is commonly found in the N-terminus of...

Ngày tải lên: 08/03/2014, 23:20

... IFN-β is influencing monocyte recruitment, survival, and/ or retention in the synovial joint. Alternatively, IFN-β may inhibit inflammatory cell infiltration indirectly, via suppression of FLS and/ or ... cell infiltration of the synovial sublining were detected and a decrease in bone erosions was observed. (b) Infiltration of inflammatory cells of the joints was scored...

Ngày tải lên: 09/08/2014, 01:23

... for analysis was the higher of the two knees. We define generalized OA (GOA) by the hypothesis that OA found in the hand is an indicator of disease in other large joints, including the spine. An individual ... chromato- graphy (HPLC) directly linked to an ASPEC (Automated Sample Preparation with Extraction Columns) system [7]. The values of pyridinoline were corrected by...

Ngày tải lên: 09/08/2014, 01:23

... maintain the cell viability and readaptation to hypoxia. Catabolic stress during the development of OA could influence the chondrocyte adaptation to hypoxia in the tissue. Our findings of catabolic-factor-induced ... radicals) may induce the expression of HIF-1α in articular chondrocytes. IL-1 has been shown both to inhibit chondrocyte anabolic activity, including the...

Ngày tải lên: 09/08/2014, 06:23

... populations and/ or genetic markers. The latter have the particular advantages of being present from the onset of the disease and of remaining unchanged by therapy. To date, the only genetic susceptibility ... after receiving verbal and written information regard- ing the nature, duration and purpose of the study. The protocol was approved by the Committee for...

Ngày tải lên: 09/08/2014, 06:23