Báo cáo y học: " Detecting DNA regulatory motifs by incorporating positional trends in information content" pdf

... discovered, denoted by L*, is increased by 100 bp, while for rap1, the final length is increased by 700 bp. These results indicate that up to a certain length, increasing the number of starting points gives ... methods using the EM algorithm can be improved simply by using more starting points or by looking into alternative starting-point procedures. However, there is Table 4 Percen...

Ngày tải lên: 09/08/2014, 20:20

... flank- ing windows of 90 bases long. Running MEME on can- didate and control windows, respectively, we identified three motifs in candidate windows and two motifs in control windows. The first two motifs ... Importantly, human Prdm9 protein was predicted to recognize the aforemen- tioned 13-mer motif CCNCCNTNNCCNC in a zinc fin- ger binding array. The f ast evolution of Prdm9 prot...

Ngày tải lên: 09/08/2014, 22:23

... density of 3 × 10 3 /cm 2 . Cells were made quiescent by incubation in 10% NCS DMEM for 2 days, washing in serum-free medium, followed by incubation in DMEM containing 0.5% NCS (vol/vol) for 7 days. Inhibitors ... Latrunculin A (Calbiochem) [62,63] or phalloidin oleate (Calbiochem) [64] for 30 minutes. Myosin polymerization was inhibited by treating cells Anti-nuclear myosin 1b (N...

Ngày tải lên: 09/08/2014, 20:21

... pathways [8]. In this study, there was no muta- tion in Abl kinase, but Src family kinases, including Lyn, was activated in the nilotinib-resistant cell line. Lyn kinase has been previously shown ... al.: Dasatinib preferentially induces apoptosis by inhibiting Lyn kinase in nilotinib-resistant chronic myeloid leukemia cell line. Journal of Hemato logy & Oncology 2011 4:32. Subm...

Ngày tải lên: 10/08/2014, 21:23

... peptides, which distinguishes HIV-1 subtype B and E infection in Thai individuals and confirmed by se- quencing, when indicated [19, 20]. Specimens and HIV DNA Assay. At entry into the cohort, ... Separation of PBMC Subsets and HIV DNA Analay- sis. Because HIV DNA is present in both lympho- cytes and monocytes, we were interested in assessing whether more HIV DNA was i...

Ngày tải lên: 31/10/2012, 15:34

... FLLG motifs are found in b1,3-GalTs and b1,3-N-acetylglucosaminyltransferases, thereby suggesting that they are more likely involved in mediating the b1,3-linkage speci®city r ather than in t ... reaction [2,3]. Also, the grouping by similarity may bring together glycosyl- transferases with a distinct s ubstrate speci®city, thereby providing some insight into the possible evolution...

Ngày tải lên: 08/03/2014, 16:20

... cardio- myopathy in Kearns–Sayre syndrome with deficiency of cyto- chrome-c-oxidase in cardiac and skeletal muscle. An enzymehistochemical—ultrammunocytochemical fine structural study in longterm ... rhesus monkey studies. Sections were then obtained using a cryostat and, depending on the study, 100–200 serial, 8–10-lm thick sections were produced. Samples were analyzed by staining ever...

Ngày tải lên: 17/03/2014, 23:20

... NA polymerases a, d,andb-like in the nuclea r e xtract, measured in arbitrary units (staining intensity) by the highly sensitive technique o f photoaffinity labeling. Single types of DNA polymerases ... active in maintaining mitotic synchrony of plasmodia b y playing the mediator between the periodic synthesis of certain proteins and the catalytic competence of DNA po lymerases. K...

Ngày tải lên: 31/03/2014, 21:21

... blocking of IgE binding. IL-10 reduces release of proinflammatory cytokines by mast cells. The role of IL-10 in costimulatory pathways on B cells is by blocking B7/CD28. Also, IL-10 inhibits DC maturation and ... humoral responses in a modified pattern. The ratio of T helper (Th)1 cytokines to Th2 cytokines is increased following SIT, and functional regulatory T cells are induced. I...

Ngày tải lên: 08/08/2014, 21:20