Báo cáo y học: "TXTGate: profiling gene groups with text-based information" ppsx

... glyceraldehyde-3-phosphate* glyceraldehyd_3_phosphat_dehydrogenas GPM1 TKL1 glyceraldehyde-3-phosphate dehydrogenase* glycolyt PGK1 CDC19 phosphoglycerate kinase* glucos TDH3 HXK2 phosphoglycerate* enzym TDH2 TYE7 mutase* ... information Genome Biology 2004, 5:R43 and one without alternative gene symbols; the former was constructed by mapping all synonymous symbols to the pri- mary gene s...

Ngày tải lên: 09/08/2014, 20:20

... precipitated with 30 lL protein A-agarose (Santa Cruz Biotechnology), washed four times with lysis buffer and analyzed by SDS/PAGE followed by autoradiography. Correction of MPS I fibroblasts by enzyme ... expression of the IDUA gene to cells in vivo for treatment of MPS I. Keywords: MPS I; Hurler syndrome; a- L -iduronidase; gene therapy. Mucopolysaccharidosis type I (MPS I) is a lyso...

Ngày tải lên: 24/03/2014, 04:21

... healthy individuals in that they bind to dsDNA with high affinity, they are often cationic in charge and they do not usually cross-react with unrelated antigens [2]. Despite intensive study, the ... autoantibody-producing B cells in the spleen of an SLE patient by analysis of hybridomas generated from splenic B cells. The aims of the present study were to identify the immunoglobulin V gen...

Ngày tải lên: 09/08/2014, 01:21

... study, gene expression profiles were analyzed from synovial lining tissues from 12 patients with early RA (duration <1 year after diagnosis) and four with longstanding RA (duration >3 years ... 11,500 and 18,000 Within RA Identification of IL-7 signalling pathway in tissues [15] characterized by lymphoid neogenesis RA FLS 19 RA 18,000 Within RA Heterogeneity between synovial tissu...

Ngày tải lên: 09/08/2014, 01:22

... present study shows that ER-α gene haplotype may be associated with primary knee OA, and genetic variations in the ER-α gene may be involved in OA. Keywords: estrogen receptor, haplotype, knee ... receptor-α gene haplotype is associated with primary knee osteoarthritis in Korean population Sheng-Yu Jin *1 , Seung-Jae Hong *2 , Hyung In Yang 3 , Sang-do Park 3 , Myung-Chul Yoo 4 ,...

Ngày tải lên: 09/08/2014, 01:23

... autoimmune encephalomyelitis (EAE). These myelin antigens include myelin basic protein, proteolipid protein, myelin-associated glycoprotein, myelin oligodendrocytic glycoprotein, golli-myelin basic protein, ... arrays are incu- bated with serum from patients or controls, followed by fluorescently labeled secondary antibody. We typically use 1:150 dilutions of human or animal serum to probe...

Ngày tải lên: 09/08/2014, 06:22

... this disease. Two recently described members of the IL10 family are IL19 and IL20. The genes encoding these cytokines are located within a highly conserved cytokine gene cluster in 1q32. Like the ... It is a clinically heterogeneous group of complex diseases, with polygenic and environmental factors all playing a role in aetiology. There are seven clinically distinct subtypes of JIA [2]....

Ngày tải lên: 09/08/2014, 08:22

... P(ER-/HER2-), P(HER2+) and P(ER+/HER2-) by P(1), P(2) and P(3), respectively. Fuzzy subtype cation cation of prognostic genes subtype signature subtype signature subtype signature Model building Model ... statistically com- pared the performance of the risk score and risk group pre- dictions through C-index by using a paired Student t-test [26,50]. Gene ontology and functional analysis...

Ngày tải lên: 09/08/2014, 20:21

... best chance to identify completely novel platypus venom genes with no homology to existing toxins. Conclusions We have identified proteins encoded by genes expressed in the platypus venom gland that ... components: alpha-latrotoxin, CRiSPs, cytolytic toxin Genes encoding proteins with homology to invertebrate venom toxins were also f ound. For example, we identi- fied seven genes encoding...

Ngày tải lên: 09/08/2014, 22:23

... fraction Comparisons Permutation null without heterogeneity vs. permutation null with heterogeneity Passenger null without heterogeneity vs. passenger null with heterogeneity Permutation null without heterogeneity vs. passenger ... methods Permutation null without heterogeneity Permutation null with heterogeneity Passenger null without heterogeneity Passenger null with heterogeneity...

Ngày tải lên: 09/08/2014, 22:23