Negative selection pressure against premature protein truncation is reduced by both alternative splicing and diploidy ppsx
Negative selection pressure against premature protein truncation is reduced by both alternative splicing and diploidy ppsx
... 5:P12 Deposited research article Negative selection pressure against premature protein truncation is reduced by both alternative splicing and diploidy Yi Xing and Christopher Lee Address: Molecular ... sense. Insertion or Negative Selection Pressure Against Premature Protein Truncation Is Reduced by both Alternative Splicing and...
Ngày tải lên: 09/08/2014, 20:20
Báo cáo hóa học: " Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer" ppt
... study and helped draft the manuscript. MAK assisted with the data collection and helped draft the manuscript. IBJ assisted with the statistical analysis. JM assisted with data collection and helped ... G2/M and no effect on apoptosis (Additional file 3). Discussion This investigation of the prognostic value of RBM3 in EOC reveals that RBM3 is an independent prognostic marker at bot...
Ngày tải lên: 18/06/2014, 16:20
báo cáo hóa học: " Astrocyte production of the chemokine macrophage inflammatory protein-2 is inhibited by the spice principle curcumin at the level of gene transcription" pptx
... design, acquisition of data, supervised all experiments, and carried out isolation of astrocytes, ELISA and transfection assays. BH isolated and amplified the MIP-2 gene promoter, and generated ... influence CNS inflammation by mechanisms distinct from its anti- oxidant and known anti-inflammatory activities, we examined the effect of this spice principle on the synthesis of MIP-2...
Ngày tải lên: 19/06/2014, 22:20
Báo cáo y học: "Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthriti" docx
... binds irreversibly to serine but not cysteine, aspartate and metallo- proteinases and labelled proteins are then isolated using streptavidin-agarose beads [13]. This is the first report showing the use of activity ... manuscript. All authors read and approved the final manuscript. Acknowledgements JMM is funded by the Dunhill Medical Trust and Arthritis Research Cam- paign. LK...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells" pdf
... (Figure 6c; P > 0.05). Discussion SLE is an autoimmune disease that is characterized by a break in tolerance to nuclear components and by multi-tissue dam- age. The pathogenesis of SLE has not been ... THP-1 cells primed with Figure 3 Distribution of IFIT4 in tissues and cells, and the effect of IFN-α on IFIT4 expressionDistribution of IFIT4 in tissues and cells, and the...
Ngày tải lên: 09/08/2014, 10:23
Báo cáo khoa học: Deadenylation of interferon-b mRNA is mediated by both the AU-rich element in the 3¢-untranslated region and an instability sequence in the coding region pot
... the deadenylation machinery is pre-existing in the cells and deadenylates IFN-b mRNA as soon as its synthesis is induced by stimulating agents. The fact that the 65-kDa protein binds ARE and CRID in UV-crosslinking ... that ARE-binding proteins such as AUF1 and TTP were able to interact with a multiprotein complex, called the exosome [8]. This complex first discovered in yeast [9...
Ngày tải lên: 17/03/2014, 10:20
Báo cáo khoa học: A hydrophobic segment within the C-terminal domain is essential for both client-binding and dimer formation of the HSP90-family molecular chaperone pptx
... chaperone; dimer; client binding. The 90-kDa heat shock protein (HSP90) is a ubiquitously distributed molecular chaperone and is an essential protein in eukaryotic cells [1]. Most, if not all, compartments ... HSP90 isoforms, HSP90a [2] and HSP90b [3], are present in the cytosol; the 94-kDa glucose-regulated protein (GRP94/gp96) is expressed in the lumen of endo- plasmic retic...
Ngày tải lên: 23/03/2014, 20:22
Báo cáo khoa học: "Genetic variability of the prion protein gene (PRNP) in wild ruminants from Italy and Scotland" ppsx
... Scotland (n = 132; 82 from the mainland and 50 from the Isle of Rhum) and during the hunting seasons from Italy (n = 191). The chamois (n = 203) and roe deer (n = 189) all came from Italy and ... included in this study. As expected, the highest genetic distance value was between the red deer from Italy and mainland Scotland (0.089). The distance value between the Italian an...
Ngày tải lên: 07/08/2014, 23:22
báo cáo khoa học: "The adsorption of biomolecules to multi-walled carbon nanotubes is influenced by both pulmonary surfactant lipids and surface chemistry" doc
... ZK, Zhang B, et al: Protein binding by functionalized multiwalled carbon nanotubes is governed by the surface chemistry of both parties and the nanotube diameter. Journal of Physical Chemistry C 2008, ... single gel bands contain high numbers of bound proteins. Nevertheless, characteristic proteins could be assigned to the bands by including the number of detected pep- tidesande...
Ngày tải lên: 11/08/2014, 00:22