Opinion Progress towards mapping the universe of protein folds Alastair Grant, David Lee and ppsx

... 2008) doi:10.1111/j.1742-4658.2008.06347.x Strategies for the chemical construction of synthetic proteins with precisely positioned post-translational modifications or their mimics offer a powerful method for dissecting the complexity of functional ... ARTICLE Chemical approaches to mapping the function of post-translational modifications David P. Gamblin, Sander...

Ngày tải lên: 18/02/2014, 17:20

... Biochem. 269) Ó FEBS 2002 Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon -c through the upregulation of protein kinase C in rat ... Japan The effect of a-tocopheryl hemisuccinate (TS) on lipo- polysaccharide (LPS) /interferon -c (IFN) -induced nitric oxide production...

Ngày tải lên: 22/02/2014, 04:20

... schematic example of how protein aggregation and amy- loid fibril formation prediction software might be used for fine-tun- ing and control of protein solubility in bacterial IBs is shown. (A) The amino ... bias specific to the available data, the authors of waltz Table 1. Protein aggregation and amyloid fibril formation prediction servers (URLs)...

Ngày tải lên: 06/03/2014, 00:20

... NEW Progress toward Resuming the Issuance of Inflation-Indexed Bonds Issuance of Inflation-Indexed Bonds (JGBi) ※1 , introduced in March 2004, have been suspended since October 2008, as the ... issuance of Inflation-Indexed Bonds& quot;. Since February 2012, the Working Group for Resumption of Issuance of Inflation-Indexed Bonds has been held a...

Ngày tải lên: 06/03/2014, 04:20

... expression of the Tec tyrosine kinase. NF-jB binds directly to the Tec promoter and induces Tec transcription The above results show that both proteasome and NF-jB inhibitors can suppress the transcriptional activity ... when NF-jB bind- ing site a was mutated, the baseline Tec promoter transcription activity decreased. Thus Tec- 420M had 67% of the activ...

Ngày tải lên: 07/03/2014, 00:20

... found in the operator sequence. RepA contains two domains, one of which binds specifically to the half-repeat. The other is the dimerization domain, which is involved in protein protein interactions ... Interestingly, in the latter case, the protein binds as a monomer [2–6]. Free in solution, the protein is essentially dimeric, but it dissociates and bind...

Ngày tải lên: 07/03/2014, 04:20

... of the combined amide I and II bands, with separate analyses of each band afterwards; and separate normalization of the amide I and II bands. All these normalizations were tested with and without ... reflect the natural abundances found in the PDB. The spectra of the 50 proteins are available on request from the authors. Protein secondary structure tab...

Ngày tải lên: 16/03/2014, 18:20

... thermophilic bacterium has provided insights into the mechanisms of protein maturation, folding, and stability Yoshihiro Sambongi 1 , Susumu Uchiyama 2, *, Yuji Kobayashi 2 , Yasuo Igarashi 3 and Jun Hasegawa 4 1 Graduate ... and are applicable to the elucidation of the dynamic features of cytochromes c. It is of interest to characterize cytochrome...

Ngày tải lên: 24/03/2014, 03:21

... because, at the end of the experiment, the function of the target protein is likely still to be unknown. However, the analysis of the submitted predictions made the assessors conclude that [13]: (a) ... of the 3D protein structure. Therefore, the set that was considered contained 64 protein targets, 29 of which had no functional annotation in any data- ba...

Ngày tải lên: 30/03/2014, 10:20

... understood, and we have investigated these questions in this work. We sought to determine the role of protein–RNA and protein–protein interactions in virus stability, measuring the effects of urea, GdnHCl ... MS2 stability FEBS Journal 273 (2006) 14631475 ê 2006 The Authors Journal compilation ê 2006 FEBS 1473 Dissecting the role of protein–protein and...

Ngày tải lên: 30/03/2014, 11:20

... Analysis of protein complexes Within the scope of this review, we will focus on summari- zing the current technical state of the art for the biochemical retrieval of associated proteins and protein complexes ... MINIREVIEW Affinity purification-mass spectrometry Powerful tools for the characterization of protein complexes Andreas Bauer and Bernhar...

Ngày tải lên: 31/03/2014, 07:20

... Moliné 5 and Sabado S Girardi 6 Abstract Introduction: One of the components of the Health Observatory for Latin American and the Caribbean (HO-LAC) is the design and implementation of metrics for ... et al.: Towards the construction of health workforce metrics for Latin America and the Caribbean. Human Resources for Health 2011 9:24....

Ngày tải lên: 18/06/2014, 17:20

... of 4 (page number not for citation purposes) Radiation Oncology Open Access Study protocol Study protocol of the German "Registry for the Detection of Late Sequelae after Radiotherapy in ... study and are involved in continuing optimization. NW is the study chairman of RiSK, devel- oped the design of the registry study, is involved in con-...

Ngày tải lên: 09/08/2014, 09:22

... research interactions information refereed research Opinion Progress towards mapping the universe of protein folds Alastair Grant, David Lee and Christine Orengo Address: Department of Biochemistry and Molecular Biology, ... 759, or 3,871 new folds. Adding together the superfolds, known folds and estimated number of new folds (54 + 759 + 3,871) we ge...

Ngày tải lên: 09/08/2014, 20:20

... expression of many genes and any given gene is typically regulated by at most a handful of transcription factors (TFs) [1]. Some studies in animals, including studies of the early development of Drosophila, ... e complexity of life does not correlate with an increased size of the list of parts (the genes) from which organisms are built, but rather with an increa...

Ngày tải lên: 09/08/2014, 20:21