... establishes the
invertebrate ancestry of vertebrate annexins, none of the 12
annexins in the vertebrate A family have (yet) been assigned a
true invertebrate ortholog.
The vertebrate A family includes the ... representative annexin proteins. Orthologs of the 12 human annexins shown in other vertebrates have the same structures, with
strict conservation of the four rep...
... metalloproteases.
The first evidence for the existence of the astacin protein
family can be traced back to the year 1967, when one of us
(R. Zwilling) observed a proteolytic activity in the digestive
fluid of the ... sequences down to the last
30–50 codons of the astacin genes was fused in frame to the
reporter gene GFP. Thus, the intergenic region as well as the
prot...
... features
Currently, the structural features of this family of proteins
are poorly defined, but information gleaned from the protein
sequence has enabled some predictions of structure and
motifs within the proteins. ... the
cytoplasmic protein coat of caveolae, making Cav-1 the first
true protein marker of caveolae [2]. Subsequent cloning of the
Cav-1 cDNA revealed that it...
... alternative splicing, and protein sequence of c19orf10. (a) The chromosomal localization of the region containing the
c19orf10 gene is indicated on the ideogram. The area containing the c19orf10 gene ... in other cases, there is an
apparent absence of c19orf10 staining (Figure 4f,h). These
observations raise the possibility that there may be either func-
tional or composition...
... inset). The absorption
spectrum of the purified enzyme was typical of the
hydroxycobalamin form of the enzyme (Fig. 2). The
recovery of the activity was 10%, and the enzyme
was purified 3669-fold. The ... footnote) in the reaction
mixture may reduce a proportion of the FMN domain,
converting some of the enzyme to the active form. The
3-fold increase in activity may...
... available regard-
ing the phospholipid and membrane binding of the
other members of the PEBP family. Consequently, the
binding characteristics of PEBP proteins, including
those of the binding of I
C
to ... centrifugation
of the samples, proteins bound to liposomes were analyzed by
SDS ⁄ PAGE of the resulting pellets. (C) The amounts of I
C
in the
pellets. The amounts of I...
... Canada, the Office of the Auditor General
and the Treasury Board Secretariat have been the primary promoters of reforms across the federal government.
While there have been variations in the reform ... is
that the indicators provide managers with the information they need to do their job.
10
While on the one hand,
indicator data should be of sufficient quality to be credibl...
... freezing.
During the winter they also increase the concentration of
the cryoprotectant, glycerol, 10-fold and desiccate to 40%
of the prediapause water content [4]. Taken together,
these adaptations ... least some of the 17 genes of the family are spaced
several kb ap art (as fo r Afp-Lu1 and 2 .7a), e ven though they
may be linked.
In both Afp-Lu1 an d Afp-Iu1, the majority...
... Thus, the proteins of the CYP11B
subfamily catalysing the last biosynthetic steps are the key
enzymes for the synthesis of both mineralocorticoids and
glucocorticoids.
From molecular cloning of the ... we
compared protein sequences of the CYP11B family. These
analyses showed that CYP11B2 proteins are more closely
related to each other than CYP11B1 proteins across species.
Fur...
... [28]. These findings agree with the
hypothesis [29] that an increase in the mitochondrial
membrane potential would slow the transport of elec-
trons through the respiratory chain, increasing the ... upregulates the expres-
sion of the mitochondrial protein uncoupling protein 2 (UCP2), and pre-
treatment with vitamin E attenuates upregulation of UCP2. These findings
suggest tha...