Protein family review The annexins docx

... establishes the invertebrate ancestry of vertebrate annexins, none of the 12 annexins in the vertebrate A family have (yet) been assigned a true invertebrate ortholog. The vertebrate A family includes the ... representative annexin proteins. Orthologs of the 12 human annexins shown in other vertebrates have the same structures, with strict conservation of the four rep...

Ngày tải lên: 09/08/2014, 20:20

... metalloproteases. The first evidence for the existence of the astacin protein family can be traced back to the year 1967, when one of us (R. Zwilling) observed a proteolytic activity in the digestive fluid of the ... sequences down to the last 30–50 codons of the astacin genes was fused in frame to the reporter gene GFP. Thus, the intergenic region as well as the prot...

Ngày tải lên: 23/03/2014, 15:21

... features Currently, the structural features of this family of proteins are poorly defined, but information gleaned from the protein sequence has enabled some predictions of structure and motifs within the proteins. ... the cytoplasmic protein coat of caveolae, making Cav-1 the first true protein marker of caveolae [2]. Subsequent cloning of the Cav-1 cDNA revealed that it...

Ngày tải lên: 09/08/2014, 20:20

... alternative splicing, and protein sequence of c19orf10. (a) The chromosomal localization of the region containing the c19orf10 gene is indicated on the ideogram. The area containing the c19orf10 gene ... in other cases, there is an apparent absence of c19orf10 staining (Figure 4f,h). These observations raise the possibility that there may be either func- tional or composition...

Ngày tải lên: 09/08/2014, 10:20

... inset). The absorption spectrum of the purified enzyme was typical of the hydroxycobalamin form of the enzyme (Fig. 2). The recovery of the activity was  10%, and the enzyme was purified 3669-fold. The ... footnote) in the reaction mixture may reduce a proportion of the FMN domain, converting some of the enzyme to the active form. The  3-fold increase in activity may...

Ngày tải lên: 18/02/2014, 08:20

... available regard- ing the phospholipid and membrane binding of the other members of the PEBP family. Consequently, the binding characteristics of PEBP proteins, including those of the binding of I C to ... centrifugation of the samples, proteins bound to liposomes were analyzed by SDS ⁄ PAGE of the resulting pellets. (C) The amounts of I C in the pellets. The amounts of I...

Ngày tải lên: 19/02/2014, 05:20

... Canada, the Office of the Auditor General and the Treasury Board Secretariat have been the primary promoters of reforms across the federal government. While there have been variations in the reform ... is that the indicators provide managers with the information they need to do their job. 10 While on the one hand, indicator data should be of sufficient quality to be credibl...

Ngày tải lên: 21/02/2014, 11:20

... freezing. During the winter they also increase the concentration of the cryoprotectant, glycerol, 10-fold and desiccate to 40% of the prediapause water content [4]. Taken together, these adaptations ... least some of the  17 genes of the family are spaced several kb ap art (as fo r Afp-Lu1 and 2 .7a), e ven though they may be linked. In both Afp-Lu1 an d Afp-Iu1, the majority...

Ngày tải lên: 21/02/2014, 15:20

... Thus, the proteins of the CYP11B subfamily catalysing the last biosynthetic steps are the key enzymes for the synthesis of both mineralocorticoids and glucocorticoids. From molecular cloning of the ... we compared protein sequences of the CYP11B family. These analyses showed that CYP11B2 proteins are more closely related to each other than CYP11B1 proteins across species. Fur...

Ngày tải lên: 22/02/2014, 07:20

... [28]. These findings agree with the hypothesis [29] that an increase in the mitochondrial membrane potential would slow the transport of elec- trons through the respiratory chain, increasing the ... upregulates the expres- sion of the mitochondrial protein uncoupling protein 2 (UCP2), and pre- treatment with vitamin E attenuates upregulation of UCP2. These findings suggest tha...

Ngày tải lên: 05/03/2014, 23:20