Báo cáo sinh học: "Restricted maximum likelihood estimation of covariances in sparse linear models" potx

... results in a factorization step as in the following In the presence of rounding errors (or in case of near dependence) we obtain entries of order eBii in place of the ... restricted maximum likeli- hood (co)variance component estimation package, in: Proceedings of an EC Sympo- sium on Application of Mixed Linear Models in the...

Ngày tải lên: 09/08/2014, 18:22

... negative estimates of variance components to zero and continue iterating. Partial sweeping of B to handle boundary constraints, monitoring and restraining the size of pivots relative to ... safe- guarding against steps in the ’wrong’ direction in early iterates, thus making the search for the maximum of the likelihood function more robust...

Ngày tải lên: 09/08/2014, 18:22

... loss in degrees of freedom due to fitting of fixed effects, REML, in contrast to ML, maximizes only the part of the likelihood of the data vector y which is independent ... traces involving the diagonal blocks, C ss and Cpp, of the inverse of the coefficient matrix. These can be derived using partitioned matrix results, utilising i...

Ngày tải lên: 09/08/2014, 22:22

... polygenic value increases with an increase in the relative magnitude of dominant loci over all polygenic loci. In addition, with dominance, the genetic variance of offspring conditional ... either independent segregation of loci or the two loci with the largest effect were linked with a recombination rate of 0.1. In the case of linkage,...

Ngày tải lên: 09/08/2014, 18:22

... surgery. Possible impact of changes in initial clinical training system Japan introduced a new clinical training system in 2004, and this will probably affect physicians' career choices in the future. ... clinical training system in 2004. Under the new system, physicians are required to experi- ence a clinical rotation in the fields of general internal medicine, general sur...

Ngày tải lên: 18/06/2014, 17:20

... by hematoxylin and eosin(HE) staining. The expression of Periostin in the xenografts was deteminned by Immunohistochemical staining and western blotting. The migration of LNCap cells after silencing ... were obtained from the Cell Bank of Chinese Academy o f Sciences(Shanghai) and maintained in RPMI 1640 with 10% of fetal bovine serum, 100 u/mL of penicillin, and 50 mg/mL strept...

Ngày tải lên: 18/06/2014, 19:20

... that of the rest of the NUTs (Figure 2b) or their positions in the single cluster of NUTs obtained using CMDS (Figure 4a), indicating that the selection of conserved paralogs for tree analysis in ... represented in more than 90% of the included prokaryotes; this definition yielded 102 NUTs. Not surprisingly, the great majority of the NUTs are genes encoding proteins involved...

Ngày tải lên: 06/08/2014, 19:20

... example, progeny of animals injected with antisense oligonucleotides against lin-4 show delayed exit in differentiation of seam cells and lack of vulva formation, known phenotypes for lin-4(lf ) [3]. ... specific inhibition of lys-6 miRNA in the ASEL neurons, where it functions to maintain left-right symmetry. is technique also successfully demonstrated the inhibition in a...

Ngày tải lên: 06/08/2014, 19:21

... use of factorial mating designs in MOET schemes either to increase response while keeping rates of inbreeding unchanged, or to decrease rates of inbreeding while keeping ... in the rate of inbreeding. However, the response was affected. DISCUSSION The control of rates of inbreeding has become important in the design of breeding programme...

Ngày tải lên: 09/08/2014, 18:21

... easier. In our study only 10.7% of participants withdrew from the study: this surprisingly positive finding may be explained in terms of perceived quality of care related to the offering of custom-made ... [22]. There is a growing interest in the possible role of exercise in enhancing QOL, reducing recurrence and other diseases, and extending survival in cancer sur...

Ngày tải lên: 08/08/2014, 16:23