Báo cáo khoa hoc:" Mixed effects linear models with t-distributions for quantitative" docx

... that includes a DNA-binding domain, a ligand-binding domain and a transactivation domain. The DNA-bind- ing domain is responsible for DNA binding specificity and dimerization, and the ligand-binding ... ê 2010 FEBS MINIREVIEW Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing Khairul I. Ansari and Subhrangsu S. Mandal Depart...

Ngày tải lên: 16/02/2014, 14:20

... directed towards histone H3 lysine 4 methylation and the enzymes involved in this covalent modification in eukaryotes ranging from yeast to human. These studies revealed a set of histone H3 lysine 4 ... CREB-binding protein; EcR, ecdysone receptor; HAT, histone acetyl transferase; H3K4, histone H3 lysine 4; HMT, histone methyltransferase; MLL, mixed lineage...

Ngày tải lên: 16/02/2014, 14:20

... proteins. Thus, the MEN1 ⁄ LEDGF-interacting domain linked to DNA-binding domains (AT-hook and MT domain) becomes disconnected from the PHD domains, the FYRN domain, the transactivating domain, ... compilation ê 2010 FEBS MINIREVIEW Mixed lineage leukemia: roles in human malignancies and potential therapy Rolf Marschalek Biochemistry, Chemistry & Pharmacy, Institute...

Ngày tải lên: 16/02/2014, 14:20

... 1841 of cell fate. Leukemias associated with loss -of- function or gain -of- function variants of MLL1 are prime exam- ples of the importance of maintaining the enzymatic activity of MLL1 under tight ... MINIREVIEW Mixed lineage leukemia: a structure–function perspective of the MLL1 protein Michael S. Cosgrove and Anamika Patel Department of Biology, S...

Ngày tải lên: 16/02/2014, 14:20

... The Authors Journal compilation ê 2009 FEBS Structural effects of a dimer interface mutation on catalytic activity of triosephosphate isomerase The role of conserved residues and complementary ... Restriction site W11F WT W11F CA CCATGGCTAGAAAATATTTTGTCGCAGCAAACTTCAAATGTAA NcoI W168F WT W168F GAACCTTTATTCGCTATT GGTACCGGTAAA KpnI WT* W11F W11F ⁄ W168F...

Ngày tải lên: 18/02/2014, 11:20

... the involvement of DNA gyrase in the antimicrobial effects of H4-(8 6–1 00) and related compounds was obtained in vitro by the mea- surement of their inhibitory activity on the supercoiling of pBR322 ... those of the inactive antimicrobial fragments HNb-( 1–1 3) and HNb-( 3–1 3) (Table 2) were not signifi- cant (Fig. 6B). The antimicrobial and anti -DNA...

Ngày tải lên: 18/02/2014, 14:20

... presence of E2. Binding of ERa and ERb was increased in both ERE1 and ERE2 of the HOXC13 promoter (Fig. 5A, lanes 1–4). The levels of E2-induced binding of ERa and ERb were higher in ERE2 than in ERE1. ... E2-dependent binding of any of the MLLs⁄ ERs, indicating no significant roles of these EREs in HOXC13 activation (Fig. 5A). To further confirm the E2-dependent b...

Ngày tải lên: 18/02/2014, 14:20

... and Alfons Juan. 2007. Domain adap- tation in statistical machine translation with mixture modelling. In Proceedings of the Second Workshop on Statistical Machine Translation, StatMT ’07, pages 177–180, ... 2010. Discriminative instance weighting for domain adapta- tion in statistical machine translation. In Proceedings of the 2010 Conference on Empirical Methods in...

Ngày tải lên: 19/02/2014, 19:20

... have shown that training phrase models can improve translation performance on a state-of- the-art phrase- based translation model. This is achieved by training phrase translation probabil- ities ... learn phrase translation probabilities for phrase- based statistical machine translation that go beyond pure counting of phrases in word-aligned training data. Most approaches...

Ngày tải lên: 07/03/2014, 22:20

... of other dialogue related features, such as Game, to classify DAs. The drawback of features such as Game is that FLSA: Extending Latent Semantic Analysis with features for dialogue act classification Riccardo ... (Kintsch, 2001). We will show that for our task, dialogue act classification, syntactic features do not help, but most dialogue related features do....

Ngày tải lên: 08/03/2014, 04:22

... Ohio, USA, June 2008. c 2008 Association for Computational Linguistics Forest Reranking: Discriminative Parsing with Non-Local Features ∗ Liang Huang University of Pennsylvania Philadelphia, PA ... 2 6 ). Alternatively, discriminative parsing is tractable with exact and efficient search based on dynamic programming (DP) if all features are restricted to be local, that is, only...

Ngày tải lên: 17/03/2014, 02:20

... 37–40, Columbus, Ohio, USA, June 2008. c 2008 Association for Computational Linguistics Beyond Log-Linear Models: Boosted Minimum Error Rate Training for N-best Re-ranking Kevin Duh ∗ Dept. of Electrical ... algorithms for machine translation rely on log-linear models, which have the potential problem of underfitting the training data. We present BoostedMERT, a novel...

Ngày tải lên: 23/03/2014, 17:20

... preferential treatment, E(Di!), increased with or2 h, as illustrated in table I. Original article Attenuating effects of preferential treatment with Student-t mixed linear models: a ... clearly inappropriate. It appears that some robust linear models can handle preferential treatment of animals better than the standard mixed effect...

Ngày tải lên: 09/08/2014, 18:21

... machinery of mixed effects linear models can be exploited. An appealing alternative is to fit linear models with robust distributions for the errors and for the random effects. ... AU2 /82 ) process with s2 wu N X2. Iv,,. The augmented joint posterior density is Original article Mixed effects linear models with t-distributions f...

Ngày tải lên: 09/08/2014, 18:21

... beneficial effects of EPO in preclinical models of shock, trauma and haemorrhage are exciting, but further studies are warranted to determine the effects of EPO on outcome (organ injury/dysfunction and ... antioxidant and anti-inflammatory effects of EPO, which have been reported in other models of disease [11]. Thus, the beneficial effects of EPO in ro...

Ngày tải lên: 13/08/2014, 03:21