ALZHEIMER''''''''S DISEASE: ITS DIAGNOSIS AND PATHOGENESIS - PART 5 doc

... V. M Y, and Trojanowski,J. Q. (1996). Full-length amyloid-fl( 1-4 2(43)) and amino-terminally modified and truncated amyloid-f142(43) de- posit in diffuse plaques. Am.J. Pathol. 149, 182 3-1 830. ... Winblad, B., and Backman, L. (2000). The course of cognitive impairment in preclinical Alzheimer disease: Three- and 6-year follow-up of a population-based sample. Arch. Neuro...

Ngày tải lên: 09/08/2014, 16:21

... 0. 85 to 0.97; Nagy et al., 1997b). However, the ALZHEIMER'S DISEASE: ITS DIAGNOSIS AND PATHOGENESIS Jillian J. Kril I Centre for Education and Research on Ageing, Concord Hospital Department ... performed. Both Lopez and colleagues (1990) and Kukall and col- leagues (1990) used four raters to evaluate the NINCDS-ADRDA criteria. Using cases with dementia (AD a...

Ngày tải lên: 09/08/2014, 16:21

... enzymes called/ 3- and y-secretases./3-secretase cleaves APP at the N-terminus of the A/3 domain, creating a 12-kD intermediate peptide, which recycles back to the cell surface, y-Secretase (s) ... extracellular domain (sAPP) and a membrane-bound 10-kD C-terminal fragment. The membrane-bound fragment is further processed by, the as yet unidentified, y-secretase at the C-terminal e...

Ngày tải lên: 09/08/2014, 16:21

... p 35 to p 25 (Lee et al., 2000). p 25 links with cell cycle-dependent kinase 5 to hyperphosphorylate tau and promote apopto- sis (Lee et al., 2000). Degenerating neurons in APP V717F Aft-producing ... presenilin-1 (PS-1) mutations on chromosome 14, and presenilin-2 (PS-2) mutations on chro- mosome 1. Each of these genes have an autosomal dominant pattern of inheritance, alth...

Ngày tải lên: 09/08/2014, 16:21

... tangles and neuropil threads. Acta Neuropathol. 87, 55 4- 56 7. Braak, H., and Braak, E. (1991). Neuropathological staging of Alzheimer-related changes. Acta Neuropathol. 82, 23 9-2 59 . Braak, ... cognitively healthy aging and Alzheimer's disease: Relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype. Arch. NeuroL 55 , 32...

Ngày tải lên: 09/08/2014, 16:21

... by patients and the method was abandoned. It may be of interest that the contro- versy over this technique was one of the first incidences of doctors criticizing and attackingeachotherinprintandincourt. Hibbs ... to scoliosis and its treatment. In 19 45, Blount introduced the so-called “Milwaukee brace”, which is still in use today [7]. Glisson developed a swing suspension by the head...

Ngày tải lên: 02/07/2014, 06:20

... Rectum 39:1 352 –1 355 49. Lehur PA, Zerbib F, Glemain P et al (2002) Compari- son of quality of life and anorectal function after arti- ficial sphincter implantation. Dis Colon Rectum 45: 508 51 3 50 . Parker ... pelvic floor. Part II: three-dimensional or volume imaging. Ultrasound Obstet Gynecol 23:6 15 6 25 9. Dietz HP, Steensma AB (20 05) Posterior compartment prolapse on two-dim...

Ngày tải lên: 10/08/2014, 15:20

... 41. 35 8.39 45 - 54 years(n = 24) 44. 45 9.21 37.68 10.32 55 - 64 years(n = 16) 45. 38 8.72 37.31 12.76 X X X X X 16 Discruption NPI - 35. 8 29.7 - 65. 5 QOL patient self-report 7.4 - 9.0 16.4 ... 45. 50 10. 05 38.84 10.10 Gender of care g iver Male 45. 15 10.01 39.40 9.80 Female 44.67 10.03 38 .56 10.30 p 0.1 65 0.628 A g e of care g iver < 45 yea...

Ngày tải lên: 25/07/2014, 11:36

... anatomical drawings and therefore his anatomical discoveries remained unknown for centuries. Andreas Vesalius ( 151 4– 156 4) is the founder of modern spinal anatomy Andreas Vesalius ( 151 4– 156 4) broke with ... is derivedfromtheGreekword“isthmos”, which means in its natural sense “isth- mus” and also “strait or narrow” [59 ]. History of Spinal Disorders Chapter 1 3 Pathogenesis Dur...

Ngày tải lên: 02/07/2014, 06:20