ALZHEIMER''''''''S DISEASE: ITS DIAGNOSIS AND PATHOGENESIS - PART 3 pptx

... and AD was first described in 19 93 in both sporadic (Saunders et al., 19 93) and familial (Corder et al., 19 93) AD. It has subsequently been confirmed in many other studies of early- and ... into the pathogenesis of AD. To date, three genes have been iden- tified. These are APP mutations on chromosome 21, presenilin-1 (PS-1) mutations on chromosome 14, and presenilin-2 (PS...

Ngày tải lên: 09/08/2014, 16:21

... performed. Both Lopez and colleagues (1990) and Kukall and col- leagues (1990) used four raters to evaluate the NINCDS-ADRDA criteria. Using cases with dementia (AD and non-AD) and nondemented controls, ... 1997b). However, the ALZHEIMER'S DISEASE: ITS DIAGNOSIS AND PATHOGENESIS Jillian J. Kril I Centre for Education and Research on Ageing, Concord Hospital D...

Ngày tải lên: 09/08/2014, 16:21

... enzymes called/ 3- and y-secretases. / 3- secretase cleaves APP at the N-terminus of the A /3 domain, creating a 12-kD intermediate peptide, which recycles back to the cell surface, y-Secretase (s) ... intermedi- ate peptide at the C-terminal end of the A /3 domain, releasing A /3 into the extracellular space. y-Secretase cleavage occurs at one of two main sites producing mainly...

Ngày tải lên: 09/08/2014, 16:21

... disease. Neu- rolog 3 42, 63 1-6 39 . Auld, D. S., Kar, S., and Quirion, R. (1998). / 3- amyloid peptides as direct cholinergic neuro- modulators: A missing link? Trends Neurosci. 21, 4 3- 4 9. Ball, ... Biological mechanisms and cognitive sequeli. Neurosci. Biobehav. Rev. 23, 61 5-6 33 . Gandy, S., and Petanceska, S. (2000). Regulation of Alzheimer / 3- amyloid pr...

Ngày tải lên: 09/08/2014, 16:21

... M Y, and Trojanowski,J. Q. (1996). Full-length amyloid-fl( 1-4 2( 43) ) and amino-terminally modified and truncated amyloid-f142( 43) de- posit in diffuse plaques. Am.J. Pathol. 149, 182 3- 1 830 . Jack, ... disease. Annu. Rev. Neurosci. 23, 7 3- 8 7. Niki, E., and Nakano, M. (1990). Estrogens as antioxidants. Methods Enzymol. 186, 33 0 -3 33 . Ohm, T. G., Busch, C., and...

Ngày tải lên: 09/08/2014, 16:21

... Behavior -0 .09 -0 .14 Night-time Behavior -0 .33 * -0 .24* Appetite/Eating Changes -0 . 13 -0 .00 Severity of NPI -0 .17 -0 .31 * Discruption of NPI -0 .20* -0 .32 * Comment: Caregiver mental health-related ... health Depression -0 .07 -0 .28* Anxiety -0 .06 -0 .10 Elation -0 .01 -0 .10 Insensitivity or indifference -0 .00 -0 .16...

Ngày tải lên: 25/07/2014, 11:36

... – fat deposits 1 13 paravertebral muscle 605 paresis 2 03, 222, 4 93 –flaccid 30 6 – of foot elevation 31 0 –spastic 30 6 parietal pleura 34 9, 35 1 Paris cast 899 Parkinson’s syndrome 33 3 partial thromboplastin ... 204, 222, 436 – syndrome 204, 491 radiculopathy 208, 261, 2 93, 30 9, 31 0, 32 0, 33 2, 437 , 4 83, 488, 494, 519, 1087 –C5 464 – – spondylotic 431 – cervical 461,...

Ngày tải lên: 02/07/2014, 06:20

... anterior tension band instrumen- tation and a cage is a promising up -and- coming technique A potential alternative to the above-mentioned combined instrumentation is the recent development of a novel “stand-alone” ... Instrumentation Chapter 3 83 F.W. Holdsworth the two-column concept [ 43] ). The surgical approach is tradi- tionally more or less from anterior depending on the body regi...

Ngày tải lên: 02/07/2014, 06:20

... KuorinkaI,JonssonB,KilbomÅ,VinterbergH,Biering-SorensenF,AnderssonG,Jorgen- sen K (1987) Standardised Nordic questionnaires for the analysis of musculoskeletal symp- toms. Appl Ergon 18: 233 –2 73 55. Lim K-L, Jacobs P, Klarenbach ... low back pain and disability. Acta Orthopaedica Scandinavica. Supplementum 234 :1 – 23 3. Andersson GBJ (1998) Epidemiology of the low back pain. Acta Ortho...

Ngày tải lên: 02/07/2014, 06:20