ALZHEIMER''''''''S DISEASE: ITS DIAGNOSIS AND PATHOGENESIS - PART 2 doc

... A/3 1-3 9/40 or sometimes A/3 1-4 2/ 43 (Haas, 1996; Neve and Robakis, 1998; Storey and Cappai, 1999; Wilson et al., 1999; Coughlan and Breen, 20 00; Gandy and Petanceska, 20 00). These peptides concentrate ... enzymes called/ 3- and y-secretases./3-secretase cleaves APP at the N-terminus of the A/3 domain, creating a 1 2- kD intermediate peptide, which recycles bac...

Ngày tải lên: 09/08/2014, 16:21

... performed. Both Lopez and colleagues (1990) and Kukall and col- leagues (1990) used four raters to evaluate the NINCDS-ADRDA criteria. Using cases with dementia (AD and non-AD) and nondemented controls, ... 1997b). However, the ALZHEIMER'S DISEASE: ITS DIAGNOSIS AND PATHOGENESIS Jillian J. Kril I Centre for Education and Research on Ageing, Concord Hospital D...

Ngày tải lên: 09/08/2014, 16:21

... V. M Y, and Trojanowski,J. Q. (1996). Full-length amyloid-fl( 1-4 2( 43)) and amino-terminally modified and truncated amyloid-f1 42( 43) de- posit in diffuse plaques. Am.J. Pathol. 149, 1 82 3-1 830. ... Korsakova 19 72; 72: 1 02 4-1 029 . (Translated in Neurosci. Behav. Physiol. 6, 31 9-3 24 .) Shi, J., Perry, G., Smith, M. A., and Friedland, R. P. (20 00). Vascular a...

Ngày tải lên: 09/08/2014, 16:21

... into the pathogenesis of AD. To date, three genes have been iden- tified. These are APP mutations on chromosome 21 , presenilin-1 (PS-1) mutations on chromosome 14, and presenilin -2 (PS -2 ) mutations ... PS -2 gene encodes a transmembrane protein that is 67% homol- ogous to PS-1 (Checler, 1999). Unlike APP and PS-1, PS -2 is expressed more strongly in peripheral tissues (pancr...

Ngày tải lên: 09/08/2014, 16:21

... Neurosci. 24 9, 29 1 -2 98. Haug, H., and Eggers, R. (1991). Morphometry of the human cortex cerebri and corpus striatum during aging. Neuro&'ol. Aging 12, 33 6-3 38. Heitner,J., and Dickson, ... Biological mechanisms and cognitive sequeli. Neurosci. Biobehav. Rev. 23 , 61 5-6 33. Gandy, S., and Petanceska, S. (20 00). Regulation of Alzheimer/3-amyloid prec...

Ngày tải lên: 09/08/2014, 16:21

... [104] 20 00 6 12 6 12 P 3 - 24 .35 .2 MacArthur et al. [4] 20 01 6135 a 26 98 P/3316 M 3 - 26 .64 .2 Chaliha et al. [105] 20 01 130 130 P 316.9 12. 3 b - Hannah et al. [106] 20 02 404 c ~20 2 P /20 0 M 3 - 9 .21 .0 Eason ... [5] 20 02 834 ~515 P/319 M 3 - 25 .93 .2 Sartore et al. [107] 20 04 519 519 P 3 - 2. 3 b Signorello et al. [104] 20 00 6 12 6...

Ngày tải lên: 10/08/2014, 15:20

... instability -0 .16 - 0.10 Aberrant Motor Behavior -0 .09 -0 .14 Night-time Behavior -0 .33* -0 .24 * Appetite/Eating Changes -0 .13 -0 .00 Severity of NPI -0 .17 -0 .31* Discruption of NPI -0 .20 * -0 . 32* ... self-report (n=95) Caregiver (n= 95) ± SD p ± SD P Age group <60 28 .44±5.34 0 .26 1 24 .89±6 .25 0.4 32 60 - 69 27 .09±4.3...

Ngày tải lên: 25/07/2014, 11:36

... 22 0 LyingonLeft/RightSide 22 0 LyingProne 22 1 AbnormalIllnessBehavior 22 1 Reproducibility 22 1 Differential Diagnosis of Spinal Pain Syndromes 22 2 Recapitulation 22 2 KeyArticles 22 3 References 22 4 9 Imaging ... Boos CoreMessages 20 1 Epidemiology 20 1 CaseIntroduction 20 2 History 20 3 Pain 20 4 Function 21 0 SpinalDeformity 21 0 PhysicalExamination 21 1 Walking 21...

Ngày tải lên: 02/07/2014, 06:20

... Cotugno (1736–1 822 ), a pro- fessor of medicine at the University of Naples, was the first to fully describe the cerebrospinal fluid and its circulation in his epoch-making Commentary on Ner- vous Sciatica ... by Jean-Andr´e Venel (1740 – 1791). h “Appareil de la nuit” developed by Venel. i Paul Randall Harring- ton (1911–1980). j Harrington hooks and rods for the treatment of scoliosi...

Ngày tải lên: 02/07/2014, 06:20